Clinical Trials at Duke University

As of June 2026, 200 paid clinical trials are recruiting at Duke University, located at 2301 ERWIN ROAD EMERGEENCY MEDICINE RESIDENCY, DURHAM, NC 27710-0001, phone (919) 681-2247 in Durham, North Carolina. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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200 clinical trials at Duke University

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A Phase 1, Dose Escalation Trial of RP-A601 in Subjects With PKP2 Variant-Mediated Arrhythmogenic Cardiomyopathy (PKP2-ACM)

for PKP2 Arrhythmogenic Cardiomyopathy (PKP2-ACM)

3 locations incl. La Jolla

Sponsor: Rocket Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT05885412·Phase 1·Recruiting

Apply to this trial

US National OCS Heart Perfusion (OHP) Registry

for Heart Transplant

37 locations incl. Phoenix

Sponsor: TransMedics

Sex: All·Age: All ages

Code: NCT05915299·Recruiting

Apply to this trial

Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Preserved Ejection Fraction

for Heart Failure, Diastolic

2 locations incl. Durham

Sponsor: Sardocor Corp.

Sex: All·Age: 50+

Code: NCT06061549·Phase 1·Recruiting

Apply to this trial

AS-1763 in Patients With Previously Treated CLL/SLL or Non-Hodgkin Lymphoma

for B-cell Malignancy

13 locations incl. Orange

Sponsor: Carna Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT05602363·Phase 1·Recruiting

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Evaluation of Eflornithine Plus Temozolomide in Patients With Newly Diagnosed Glioblastoma or Astrocytoma

for Glioblastoma, IDH-wildtype

8 locations incl. Birmingham

Sponsor: Orbus Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05879367·Phase 1·Recruiting

Apply to this trial

SenseToKnow Autism Screening Device Validation Study

for Autism

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 16 Months - 36 Months·Accepts healthy volunteers

Code: NCT05874466·Recruiting

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A Phase 2 Study of the Ketogenic Diet vs Standard Anti-cancer Diet Guidance for Patients With Glioblastoma in Combination With Standard-of-care Treatment

for Glioblastoma Multiforme

5 locations incl. Los Angeles

Sponsor: Cedars-Sinai Medical Center

Sex: All·Age: 18+

Code: NCT05708352·Phase 2·Recruiting

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Daratumumab in Primary Antiphospholipid Syndrome

for Autoimmune Disorders

Drug: Daratumumab

8 locations incl. Baltimore

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 65

Code: NCT05671757·Phase 1, Phase 2·Recruiting

Apply to this trial

FOG-001 in Locally Advanced or Metastatic Solid Tumors

for Cancer

31 locations incl. Phoenix

Sponsor: Parabilis Medicines, Inc.

Sex: All·Age: 18+

Code: NCT05919264·Phase 1, Phase 2·Recruiting

Apply to this trial

A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation

for Heart Failure

Drug: Ziltivekimab

184 locations incl. Alexander City

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT05636176·Phase 3·Recruiting

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An Open-label Study of XEN1101 in Epilepsy

for Focal Epilepsy

53 locations incl. Phoenix

Sponsor: Xenon Pharmaceuticals Inc.

Sex: All·Age: 12+

Code: NCT05718817·Phase 3·Enrolling By Invitation

Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women

for Heart Diseases

42 locations incl. Los Angeles

Sponsor: Weill Medical College of Cornell University

Sex: Female·Age: 18+

Code: NCT04124120·Recruiting

Apply to this trial

Study of SGR-1505 in Mature B-Cell Neoplasms

for Mature B-Cell Neoplasm

16 locations incl. Gilbert

Sponsor: Schrödinger, Inc.

Sex: All·Age: 18+

Code: NCT05544019·Phase 1·Recruiting

Apply to this trial

Study Comparing Acceptance and Commitment Therapy to Supportive Diabetes Counseling and a Waitlist Control for Eating Disorders in Type 1 Diabetes

for Type 1 Diabetes

2 locations incl. Durham

Sponsor: Duke University

Sex: All·Age: 16 - 50

Code: NCT05540704·Recruiting

Apply to this trial

Achieving Understanding of the Natural History of Sickle Cell Trait (AUNT)

for Sickle Cell Trait

10 locations incl. Birmingham

Sponsor: National Alliance for Sickle Cell Centers

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06071377·Recruiting

Apply to this trial

Web-based Pain Coping Skills Training for Breast Cancer Survivors With AI-Associated Arthralgia

for Breast Cancer

2 locations incl. Chicago

Sponsor: Northwestern University

Sex: Female·Age: 18+

Code: NCT05703178·Phase 3·Recruiting

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Prototyping a Device for Automating Stool and Urine Output Tracking

for Waste Output

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05438199·Recruiting

Apply to this trial

Safe Treatment for Emergency Presentation for Suicidal Ideation and Behavior in Youth

for Suicide

5 locations incl. Los Angeles

Sponsor: University of California, Los Angeles

Sex: All·Age: 13 - 24

Code: NCT05304065·Phase 2·Recruiting

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Phase 3 Study of Teclistamab in Combination With Lenalidomide and Teclistamab Alone Versus Lenalidomide Alone in Participants With Newly Diagnosed Multiple Myeloma as Maintenance Therapy Following Autologous Stem Cell Transplantation

for Multiple Myeloma

Drug: Teclistamab

42 locations incl. Phoenix

Sponsor: European Myeloma Network B.V.

Sex: All·Age: 18+

Code: NCT05243797·Phase 3·Recruiting

Apply to this trial

Ventripoint Single Ventricle Study

for Congenital Heart Disease

1 location in Durham

Sponsor: Duke University

Sex: All·Age: All ages

Code: NCT05262907·Recruiting

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Efficacy of Atenativ in Patients With Congenital Antithrombin Deficiency Undergoing Surgery or Delivery

for Congenital Antithrombin Deficiency

5 locations incl. Washington D.C.

Sponsor: Octapharma

Sex: All·Age: 12 - 80

Code: NCT04918173·Phase 3·Recruiting

Apply to this trial

GEMINI-NSCLC: NSCLC Biomarker Study

for Non-Small Cell Lung Cancer

58 locations incl. Birmingham

Sponsor: Tempus AI

Sex: All·Age: 18+

Code: NCT05236114·Recruiting

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Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODS

for Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome (MODS)

32 locations incl. Birmingham

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 1 Day - 17

Code: NCT05267821·Phase 2, Phase 3·Recruiting

Apply to this trial

Specialty Compared to Oncology Delivered Palliative Care for Patients With Acute Myeloid Leukemia

for Relapsed Adult AML

20 locations incl. Birmingham

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 120·Accepts healthy volunteers

Code: NCT05237258·Recruiting

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Mechanisms of Disease R/R in CAR-T for Hematologic Malignancies

for Hematologic Malignancy

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT05397132·Recruiting

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Ethicon Pelvic Mesh Post Market Clinical Follow-up Registry

for Stress Urinary Incontinence

4 locations incl. New Haven

Sponsor: Ethicon, Inc.

Sex: Female·Age: 21+

Code: NCT04829175·Recruiting

Apply to this trial

Long-Term Follow-Up Study of RGX-314 Administered in the Suprachoroidal Space for Participants With Diabetic Retinopathy

for Diabetic Retinopathy, DR

19 locations incl. Phoenix

Sponsor: AbbVie

Sex: All·Age: All ages

Code: NCT05296447·Enrolling By Invitation

Global Utilization And Registry Database for Improved preservAtion of doNor Livers

for Liver Diseases

7 locations incl. Birmingham

Sponsor: Paragonix Technologies

Sex: All·Age: 18+

Code: NCT05082077·Enrolling By Invitation

A Phase 1/2 Study of Enzomenib (DSP-5336) in Patients With Acute Leukemia (Horizen-1)

for Leukemia, Myeloid, Acute

33 locations incl. Newport Beach

Sponsor: Sumitomo Pharma America, Inc.

Sex: All·Age: 12+

Code: NCT04988555·Phase 1, Phase 2·Recruiting

Apply to this trial

Open Versus Arthroscopic Stabilization of Shoulder Instability With Subcritical Bone Loss: The OASIS Trial

for Shoulder Dislocation

15 locations incl. Tempe

Sponsor: University of Pittsburgh

Sex: All·Age: 17 - 50

Code: NCT04809064·Recruiting

Apply to this trial

X-ray Psoralen Activated Cancer Therapy in Head and Neck, Breast, Sarcoma and Melanoma

for Advanced Solid Tumor Cancer

4 locations incl. Washington D.C.

Sponsor: Immunolight, LLC

Sex: All·Age: 18+

Code: NCT04389281·Phase 1·Recruiting

Apply to this trial

Pediatric Post-Approval Registry

for Obstructive Sleep Apnea

8 locations incl. Aurora

Sponsor: Inspire Medical Systems, Inc.

Sex: All·Age: 18 - 21

Code: NCT04457154·Recruiting

Apply to this trial

American Lung Association (ALA) Lung Health Cohort

for Lung Diseases

37 locations incl. Birmingham

Sponsor: Johns Hopkins University

Sex: All·Age: 25 - 35·Accepts healthy volunteers

Code: NCT04543461·Recruiting

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Combination Therapy for the Treatment of Diffuse Midline Gliomas

for Diffuse Intrinsic Pontine Glioma

19 locations incl. Birmingham

Sponsor: University of California, San Francisco

Sex: All·Age: 2 - 39

Code: NCT05009992·Phase 2·Recruiting

Apply to this trial

CAP-100 for Subjects With Relapsed/Refractory Chronic Lymphocytic Leukemia

for Lymphocytic Leukemia, Chronic

2 locations incl. Boston

Sponsor: Catapult Therapeutics

Sex: All·Age: 18+

Code: NCT04704323·Phase 1·Recruiting

Apply to this trial

FaCT Trial (Facilitated Cascade Testing Trial)

for BRCA1 Mutation

3 locations incl. New York

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04613440·Recruiting

Apply to this trial

Registry of Arthrex Hand and Wrist Products

for Ulnar/Radial Collateral Ligament Reconstruction

5 locations incl. Phoenix

Sponsor: Arthrex, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05046600·Recruiting

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CORCYM Mitral, Aortic aNd Tricuspid Post-maRket Study in a reAl-world Setting

for Cardiac Valve Disease

9 locations incl. Indianapolis

Sponsor: Corcym S.r.l

Sex: All·Age: All ages

Code: NCT05002543·Recruiting

Apply to this trial

Long Term Follow up of the LTOG Cohort

for Lung Transplant Failure and Rejection

10 locations incl. Birmingham

Sponsor: University of Pennsylvania

Sex: All·Age: 13+

Code: NCT04787822·Enrolling By Invitation

Exercise and Soft Tissue Sarcoma

for Soft Tissue Sarcoma

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 85

Code: NCT04921917·Recruiting

Apply to this trial