Clinical Trials at Karmanos Cancer Institute

As of June 2026, 91 paid clinical trials are recruiting at Karmanos Cancer Institute, located at Karmanos Cancer Institute, 4100 John R St, Detroit, MI 48201, phone (800) 527-6266 in Detroit, Michigan. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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91 clinical trials at Karmanos Cancer Institute

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DapagliFLOzin in Renal AL Amyloidosis (FLORAL)

for Renal AL Amyloidosis

Drug: Dapagliflozin

1 location in Detroit

Sponsor: Barbara Ann Karmanos Cancer Institute

Sex: All·Age: 18+

Code: NCT06420167·Phase 2·Recruiting

Apply to this trial

Study of SGR-3515 In Participants With Advanced Solid Tumors.

for Advanced Solid Tumor

13 locations incl. New Haven

Sponsor: Schrödinger, Inc.

Sex: All·Age: 18+

Code: NCT06463340·Phase 1·Recruiting

Apply to this trial

A Study of Amivantamab Alone or in Addition to Other Treatment Agents in Participants With Head and Neck Cancer

for Squamous Cell Carcinoma of Head and Neck

Drug: Amivantamab

15 locations incl. La Jolla

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT06385080·Phase 1, Phase 2·Recruiting

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A Study to Evaluate TAR-210 Versus Single Agent Intravesical Cancer Treatment in Participants With Bladder Cancer

for Non-Muscle Invasive Bladder Neoplasms

38 locations incl. Little Rock

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT06319820·Phase 3·Recruiting

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Phase 1, Safety and Tolerability Study of XmAb541 in Advanced Solid Tumors

for Ovarian Cancer

17 locations incl. Duarte

Sponsor: Xencor, Inc.

Sex: All·Age: 15+

Code: NCT06276491·Phase 1·Recruiting

Apply to this trial

Safety and Tolerability of Ziftomenib Combinations in Patients With Relapsed/Refractory Acute Myeloid Leukemia

for AML

38 locations incl. Gilbert

Sponsor: Kura Oncology, Inc.

Sex: All·Age: 18+

Code: NCT06001788·Phase 1·Recruiting

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A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors

for Advanced Solid Tumors With KRAS G12C Mutations

15 locations incl. La Jolla

Sponsor: Frontier Medicines Corporation

Sex: All·Age: 18+

Code: NCT06244771·Phase 1, Phase 2·Recruiting

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FT825/ONO-8250, an Off-the-Shelf, HER2 CAR-T, With or Without Monoclonal Antibodies in Advanced Solid Tumors

for Advanced Solid Tumor

14 locations incl. Gilbert

Sponsor: Fate Therapeutics

Sex: All·Age: 18+

Code: NCT06241456·Phase 1·Recruiting

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Iberdomide and Daratumumab As Maintenance Therapy After an Autologous Stem Cell Transplant for Multiple Myeloma

for Multiple Myeloma

Drug: Daratumumab

2 locations incl. Detroit

Sponsor: Barbara Ann Karmanos Cancer Institute

Sex: All·Age: 18+

Code: NCT06107738·Phase 2·Recruiting

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A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

for Carcinoma, Non-Small-Cell Lung

Drug: LY3537982

91 locations incl. Huntsville

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06119581·Phase 3·Recruiting

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A Window of Opportunity Trial to Learn if Linvoseltamab is Safe and Well Tolerated, and How Well it Works in Adult Participants With Recently Diagnosed Multiple Myeloma Who Have Not Already Received Treatment

for Multiple Myeloma

Drug: Linvoseltamab

13 locations incl. Los Angeles

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT05828511·Phase 1, Phase 2·Recruiting

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A Trial to Learn if Odronextamab is Safe and Well-Tolerated and How Well it Works Compared to Rituximab Combined With Different Types of Chemotherapy for Adult Participants With Previously Untreated Follicular Lymphoma

for Follicular Lymphoma (FL)

Drug: Odronextamab

20 locations incl. Tucson

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06091254·Phase 3·Recruiting

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A First-in-human Study of PARP1 Selective Inhibitor, IMP1734, in Participants With Advanced Solid Tumors

for Advanced Solid Tumor

23 locations incl. Tucson

Sponsor: Eikon Therapeutics

Sex: All·Age: 18 - 89

Code: NCT06253130·Phase 1, Phase 2·Recruiting

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BGB-43395 Alone or as Part of Combination Therapies in Participants With Breast Cancer and Other Advanced Solid Tumors

for Advanced Solid Tumor

10 locations incl. Denver

Sponsor: BeOne Medicines

Sex: All·Age: 18+

Code: NCT06120283·Phase 1·Recruiting

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Safety, PK, and Preliminary Efficacy of MBRC-101 in Advanced Refractory Solid Tumors

for Cancer

17 locations incl. San Francisco

Sponsor: MBrace Therapeutics

Sex: All·Age: 18+

Code: NCT06014658·Phase 1, Phase 2·Recruiting

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A First-In-Human, Phase 1 Study Evaluating Oral TACC3 PPI Inhibitor, AO-252, in Advanced Solid Tumors With or Without Brain Metastases

for Solid Tumor Malignancies

5 locations incl. Detroit

Sponsor: A2A Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT06136884·Phase 1·Recruiting

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A Study to Investigate the Safety and Tolerability of Ziftomenib in Combination With Venetoclax/Azacitidine, Venetoclax, 7+3, or 7+3+Quizartinib in Patients With AML

for Acute Myeloid Leukemia

Drug: Venetoclax

44 locations incl. Phoenix

Sponsor: Kura Oncology, Inc.

Sex: All·Age: 18+

Code: NCT05735184·Phase 1·Recruiting

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Phase 1 Study Evaluating BA3182 in Patients With Advanced Adenocarcinoma.

for Advanced Adenocarcinoma

9 locations incl. Irvine

Sponsor: BioAtla, Inc.

Sex: All·Age: 18+

Code: NCT05808634·Phase 1·Recruiting

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Isatuximab During Stem Cell Collection and Transplant in Patients With Multiple Myeloma and Lymphoma

for Lymphoma

2 locations incl. Detroit

Sponsor: Divaya Bhutani

Sex: All·Age: 18+

Code: NCT05346809·Phase 2·Recruiting

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Open-Label Study to Evaluate the Safety, Tolerability, PK, and Efficacy of INX-315 in Patients With Advanced Cancer

for Breast Cancer

15 locations incl. Orlando

Sponsor: Incyclix Bio

Sex: All·Age: 18+

Code: NCT05735080·Phase 1, Phase 2·Recruiting

Apply to this trial

Dietary Reporting in the Amyloidoses

for Amyloidosis

1 location in Detroit

Sponsor: Barbara Ann Karmanos Cancer Institute

Sex: All·Age: 18+

Code: NCT05738005·Recruiting

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A Study of XMT-2056 in Advanced/Recurrent Solid Tumors That Express HER2

for HER2-positive Breast Cancer

14 locations incl. Los Angeles

Sponsor: Mersana Therapeutics

Sex: All·Age: 18+

Code: NCT05514717·Phase 1·Recruiting

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A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors

for Advanced Solid Tumors

18 locations incl. Loma Linda

Sponsor: Marengo Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05592626·Phase 1, Phase 2·Recruiting

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Study to Evaluate the Pharmacokinetics and Safety of Pralatrexate in Patients With Advanced Solid Tumor or Hematological Malignancy and Either Normal Hepatic Function or Mild, Moderate, or Severe Hepatic Impairment

for Advanced Solid Tumors

4 locations incl. Cerritos

Sponsor: Acrotech Biopharma Inc.

Sex: All·Age: 18+

Code: NCT07036133·Phase 1·Recruiting

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A Provider Intervention to Reduce Financial Toxicity in Patients With Cancer Through Improved Treatment Cost Discussions

for Healthy

1 location in Detroit

Sponsor: Barbara Ann Karmanos Cancer Institute

Sex: All·Age: All ages

Code: NCT07042191·Recruiting

Apply to this trial

Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)

for High Grade Epithelial Ovarian Cancer

37 locations incl. Phoenix

Sponsor: Genmab

Sex: All·Age: 18+

Code: NCT05579366·Phase 1, Phase 2·Recruiting

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A Study of TSC-100 and TSC-101 in AML, ALL and MDS in Patients Undergoing Allogeneic Peripheral Blood Stem Transplantation

for AML

15 locations incl. Duarte

Sponsor: TScan Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05473910·Phase 1·Recruiting

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A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors

for Carcinoma, Non-Small-Cell Lung

25 locations incl. Birmingham

Sponsor: Seagen, a wholly owned subsidiary of Pfizer

Sex: All·Age: 18+

Code: NCT05208762·Phase 1·Recruiting

Apply to this trial

F-Tryptophan PET/CT in Human Cancers

for Intracranial Glioma

1 location in Detroit

Sponsor: Barbara Ann Karmanos Cancer Institute

Sex: All·Age: 18+

Code: NCT05556473·Phase 1·Recruiting

Apply to this trial

Efficacy & Safety of Olvi-Vec and Platinum-doublet + Bevacizumab Compared to Physician's Choice of Chemotherapy and Bevacizumab in Platinum-Resistant/Refractory Ovarian Cancer (PRROC) (OnPrime, GOG-3076)

for Platinum-resistant Ovarian Cancer

Drug: Bevacizumab

31 locations incl. Mobile

Sponsor: Genelux Corporation

Sex: Female·Age: 18+

Code: NCT05281471·Phase 3·Recruiting

Apply to this trial

A Phase 2 Study of ACR-368 in Endometrial Adenocarcinoma

for Endometrial Adenocarcinoma

69 locations incl. Mobile

Sponsor: Acrivon Therapeutics

Sex: Female·Age: 18+

Code: NCT05548296·Phase 2·Recruiting

Apply to this trial

Chiauranib for Advanced Solid Malignant Tumors and Relapsed/Refractory SCLC.

for Small Cell Lung Cancer

11 locations incl. Encinitas

Sponsor: Chipscreen Biosciences, Ltd.

Sex: All·Age: 18+

Code: NCT05271292·Phase 1, Phase 2·Recruiting

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BP1001-A in Patients With Advanced or Recurrent Solid Tumors

for Solid Tumor, Adult

4 locations incl. Silver Spring

Sponsor: Bio-Path Holdings, Inc.

Sex: All·Age: 18+

Code: NCT04196257·Phase 1·Recruiting

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A Study to Examine the Effects of Novel Therapy Linvoseltamab in Combination With Other Cancer Treatments for Adult Patients With Multiple Myeloma That is Resistant to Current Standard of Care Treatments

for Multiple Myeloma

Drug: Linvoseltamab

13 locations incl. La Jolla

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT05137054·Phase 1·Recruiting

Apply to this trial

A Study of Disitamab Vedotin Alone or With Pembrolizumab in Urothelial Cancer That Expresses HER2

for Urothelial Carcinoma

159 locations incl. Gilbert

Sponsor: Seagen, a wholly owned subsidiary of Pfizer

Sex: All·Age: 18+

Code: NCT04879329·Phase 2·Recruiting

Apply to this trial

Asciminib as Initial Therapy for Patients With Chronic Myeloid Leukemia in Chronic Phase

for Chronic Myeloid Leukemia, Chronic Phase

7 locations incl. Atlanta

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18+

Code: NCT05143840·Phase 2·Recruiting

Apply to this trial

Study of ONO-4685 in Patients With Relapsed or Refractory T Cell Lymphoma

for Relapsed or Refractory T Cell Lymphoma

20 locations incl. Birmingham

Sponsor: Ono Pharmaceutical Co., Ltd.

Sex: All·Age: 18+

Code: NCT05079282·Phase 1·Recruiting

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A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)

for Metastatic Colorectal Cancer

35 locations incl. Birmingham

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT04929223·Phase 1·Recruiting

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A Dose-Escalation and Expansion Study of BGB-16673 in Participants With B-Cell Malignancies

for B-cell Malignancy

31 locations incl. Birmingham

Sponsor: BeOne Medicines

Sex: All·Age: 18+

Code: NCT05006716·Phase 1, Phase 2·Recruiting

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A Beta-only IL-2 ImmunoTherapY Study

for Advanced Solid Tumor

7 locations incl. San Diego

Sponsor: Medicenna Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05086692·Phase 1, Phase 2·Recruiting

Apply to this trial