A Study of XMT-2056 in Advanced/Recurrent Solid Tumors That Express HER2

Part of paid clinical trials in Los Angeles, California.

Sponsor
Mersana Therapeutics
Study ID
NCT05514717
Phase
PHASE1
Status
Recruiting
Apply to this trial

Conditions

  • HER2 Low Breast Cancer
  • HER2-positive Breast Cancer
  • HER2-positive Colorectal Cancer
  • HER2-positive Gastric Cancer
  • HER2-positive Non-Small Cell Lung Cancer
  • HER2-positive Tumors

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • XMT-2056 — DRUG
    XMT-2056 will be administered through a vein in your arm or port catheter (intravenously)

Study Details

A Study of XMT-2056 in advanced/recurrent solid tumors that express HER2.

Key Dates

Start date
Jan 24, 2023
Status verified
Jul 2025
Primary completion
Apr 30, 2027
Completion
Apr 30, 2027

Study Design

Enrollment
162 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: XMT-2056
    XMT-2056 alone (monotherapy)

Primary Outcome Measure

Frequency of dose-limiting toxicities (DLTs) associated with XMT-2056 during the first cycle of treatment (Dose Escalation) [ Time Frame: 15 months ]

Central Contacts

Locations (14)

FacilityCityStateZIPSite coordinators
University of California Los AngelesLos AngelesCalifornia90095
Nicholas McAndrew, MD
University of South CaliforniaLos AngelesCalifornia90033
Anthony El-Khoueiry, MD
Stanford University Medical CenterStanfordCalifornia94305
Christopher Chen, MD
AdventHealth CelebrationCelebrationFlorida34747
Guru Sonpavde, MD
Emory Healthcare, Emory ClinicAtlantaGeorgia30322
Manali Bhave, MD
Massachusetts General HospitalBostonMassachusetts02114
Samuel Klempner, MD
Karmanos Cancer InstituteDetroitMichigan48201
Jailan Elayoubi, MD
Hackensack University Medical CenterHackensackNew Jersey07601
Martin Gutierrez, MD
Icahn School of Medicine at Mount SinaiNew YorkNew York10029
Deborah Doroshow, MD
Deborah Doroshow (PRINCIPAL_INVESTIGATOR)
Memorial Sloan Kettering Cancer CenterNew YorkNew York10065
Ezra Rosen, MD
New York University Medical Oncology AssociatesNew YorkNew York10016
Kristen Spencer, MD
The Ohio State University Comprehensive Cancer CenterColumbusOhio43212
Arya Roy, MD
Tennessee Oncology, PLLCNashvilleTennessee37203
Erika P Hamilton, MD
The University of Texas MD Anderson Cancer CenterHoustonTexas77030
Ecaterina Dumbrava, MD

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By research site
University of California Los Angeles· Los Angeles, CAUniversity of South California· Los Angeles, CAStanford University Medical Center· Stanford, CAAdventHealth Celebration· Celebration, FLEmory Healthcare, Emory Clinic· Atlanta, GAMassachusetts General Hospital· Boston, MA

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