Clinical Trials at Cleveland Clinic

As of June 2026, 375 paid clinical trials are recruiting at Cleveland Clinic, located at Cleveland Clinic Mellen Center, 1950 E 89th St U Bldg, Cleveland, OH 44195, phone (216) 444-8600 in Cleveland, Ohio. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

Filter results

Filter results

State

City

Facility

Phase

Study type

Intervention

Recruitment status

Condition

Sex

Age

Healthy volunteers only

375 clinical trials at Cleveland Clinic

·Clear filters·↓ Download CSV

SELUTION4BTK Trial

for Peripheral Arterial Disease

30 locations incl. Chandler

Sponsor: M.A. Med Alliance S.A.

Sex: All·Age: 18+

Code: NCT05055297·Recruiting

Apply to this trial

REMASTer: REcurrent Brain Metastases After SRS Trial

for Brain Metastases

9 locations incl. Los Angeles

Sponsor: Monteris Medical

Sex: All·Age: 18+

Code: NCT05124912·Recruiting

Apply to this trial

cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

for Brain Cancer

17 locations incl. Duarte

Sponsor: Adela, Inc

Sex: All·Age: 40+·Accepts healthy volunteers

Code: NCT05366881·Recruiting

Apply to this trial

A Study of NX-5948 in Adults With Relapsed/Refractory B-cell Malignancies

for Chronic Lymphocytic Leukemia (CLL)

18 locations incl. Duarte

Sponsor: Nurix Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05131022·Phase 1·Recruiting

Apply to this trial

Long-Term Follow-up Study

for Lymphoma, Non-Hodgkin

31 locations incl. Birmingham

Sponsor: Caribou Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT05332054·Enrolling By Invitation

Study of Stereotactic Radiosurgery With Olaparib Followed by Durvalumab and Physician's Choice Systemic Therapy in Subjects With Breast Cancer Brain Metastases

for Breast Cancer

Drug: Durvalumab

7 locations incl. Birmingham

Sponsor: Colette Shen

Sex: All·Age: 18+

Code: NCT04711824·Phase 1, Phase 2·Recruiting

Apply to this trial

CEM-Plate and CEM-Cage First-In-Human Use Efficacy Study

for Neck Pain

4 locations incl. Union

Sponsor: ReVivo Medical, Corp.

Sex: All·Age: 22 - 79

Code: NCT04883411·Recruiting

Apply to this trial

Secondary Mitral Regurgitation Treatment With MitraClip and Assessment by Cardiac Magnetic Resonance

for Heart Failure and Reduced Ejection Fraction

5 locations incl. Minneapolis

Sponsor: Minneapolis Heart Institute Foundation

Sex: All·Age: 18+

Code: NCT07131631·Recruiting

Apply to this trial

Trisol System EFS Study

for Tricuspid Regurgitation

7 locations incl. Los Angeles

Sponsor: Trisol Medical

Sex: All·Age: 18+

Code: NCT04905017·Recruiting

Apply to this trial

Percutaneous or Surgical Repair In Mitral Prolapse And Regurgitation for ≥60 Year-olds (PRIMARY)

for Mitral Valve Regurgitation

24 locations incl. Los Angeles

Sponsor: Annetine Gelijns

Sex: All·Age: 60+

Code: NCT05051033·Recruiting

Apply to this trial

AN INTERNATIONAL, OBSERVATIONAL, BLINDED STUDY TO ASSESS THE PERFORMANCE OF THE CORDIO HEARO SYSTEM

for Heart Failure

37 locations incl. Fairhope

Sponsor: Cordio Medical

Sex: All·Age: 22+

Code: NCT06378632·Recruiting

Apply to this trial

HA35 Acute Alcohol Study

for Healthy Controls

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 21 - 65·Accepts healthy volunteers

Code: NCT05025865·EARLY_Phase 1·Recruiting

Apply to this trial

Novel Clinical Utility of Retinal Imaging in Patients With Heart Failure

for Heart Failure

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05086978·Enrolling By Invitation

Efficacy of the COronary SInus Reducer in Patients With Refractory Angina II

for Refractory Angina

70 locations incl. Phoenix

Sponsor: Shockwave Medical, Inc.

Sex: All·Age: 18+

Code: NCT05102019·Recruiting

Apply to this trial

Single and Multiple Dose Escalation of PHIN-214 in Child-Pugh A and B Liver Cirrhotics

for Cirrhosis, Liver

9 locations incl. Chandler

Sponsor: PharmaIN

Sex: All·Age: 18 - 75

Code: NCT05490888·Phase 1·Recruiting

Apply to this trial

Long-term Follow-up Study for Participants of Kite-Sponsored Interventional Studies Treated With Gene-Modified Cells

for Solid and Hematological Malignancies

49 locations incl. Gilbert

Sponsor: Kite, A Gilead Company

Sex: All·Age: All ages

Code: NCT05041309·Enrolling By Invitation

A Study Assessing Corneal Endothelial Cells in Participants With Neovascular Age-related Macular Degeneration (nAMD) Treated With the Port Delivery System With Ranibizumab (PDS)

for Neovascular Age-related Macular Degeneration

Drug: Ranibizumab

50 locations incl. Mesa

Sponsor: Genentech, Inc.

Sex: All·Age: 50+

Code: NCT04853251·Phase 4·Recruiting

Apply to this trial

Study of ONO-4685 in Patients With Relapsed or Refractory T Cell Lymphoma

for Relapsed or Refractory T Cell Lymphoma

20 locations incl. Birmingham

Sponsor: Ono Pharmaceutical Co., Ltd.

Sex: All·Age: 18+

Code: NCT05079282·Phase 1·Recruiting

Apply to this trial

HMB Enriched Amino Acids to Reverse Muscle Loss in Cirrhosis

for Cirrhosis, Liver

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 21 - 65

Code: NCT05166499·Recruiting

Apply to this trial

HIP Fracture Accelerated Surgical TreaTment And Care tracK 2 Trial

for Hip Fractures

19 locations incl. Chandler

Sponsor: Population Health Research Institute

Sex: All·Age: 45+

Code: NCT04743765·Recruiting

Apply to this trial

First in Human Study of TORL-1-23 in Participants With Advanced Cancer

for Advanced Solid Tumor

9 locations incl. Fullerton

Sponsor: TORL Biotherapeutics, LLC

Sex: All·Age: 18+

Code: NCT05103683·Phase 1·Recruiting

Apply to this trial

ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation

for Bladder Carcinoma

33 locations incl. Birmingham

Sponsor: Guardant Health, Inc.

Sex: All·Age: 18+

Code: NCT05059444·Recruiting

Apply to this trial

Study in Parkinson Disease of Exercise

for Parkinson Disease

24 locations incl. Birmingham

Sponsor: Northwestern University

Sex: All·Age: 40 - 80

Code: NCT04284436·Recruiting

Apply to this trial

IT Matters: The Erectile Restoration Registry

for Erectile Dysfunction

21 locations incl. Los Angeles

Sponsor: Boston Scientific Corporation

Sex: Male·Age: 18+·Accepts healthy volunteers

Code: NCT04200937·Enrolling By Invitation

Leveraging Methylated DNA Markers (MDMs) in the Detection of Endometrial Cancer, Ovarian Cancer, and Cervical Cancer

for Endometrial Cancer

24 locations incl. Phoenix

Sponsor: Mayo Clinic

Sex: Female·Age: 18+

Code: NCT05051722·Recruiting

Apply to this trial

EFS of the CardioMech MVRS

for Mitral Regurgitation

12 locations incl. Thousand Oaks

Sponsor: CardioMech AS

Sex: All·Age: 18+

Code: NCT04820764·Recruiting

Apply to this trial

A Study of Nipocalimab Administered to Adults With Generalized Myasthenia Gravis

for Myasthenia Gravis

Drug: Nipocalimab

24 locations incl. Paradise Valley

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT04951622·Phase 3·Recruiting

Apply to this trial

Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs

for Liver Diseases

18 locations incl. Los Angeles

Sponsor: European Foundation for Study of Chronic Liver Failure

Sex: All·Age: 18 - 80

Code: NCT04613921·Recruiting

Apply to this trial

CORCYM Mitral, Aortic aNd Tricuspid Post-maRket Study in a reAl-world Setting

for Cardiac Valve Disease

9 locations incl. Indianapolis

Sponsor: Corcym S.r.l

Sex: All·Age: All ages

Code: NCT05002543·Recruiting

Apply to this trial

Distal Evaluation of Functional Performance with Intravascular Sensors to Assess the Narrowing Effect: Guided Physiologic Stenting

for Coronary Artery Disease

40 locations incl. Birmingham

Sponsor: Philips Clinical & Medical Affairs Global

Sex: All·Age: 18+

Code: NCT04451044·Enrolling By Invitation

Uterine Manipulation During Minimally Invasive Surgery for Early Stage Endometrial Cancer

for ENDOMETRIAL CANCER

5 locations incl. Cleveland

Sponsor: Anthony Costales, MD

Sex: Female·Age: 18 - 90

Code: NCT04586959·Recruiting

Apply to this trial

Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Aficamten in Adults With HCM

for Symptomatic Hypertrophic Cardiomyopathy (HCM)

Drug: Aficamten

52 locations incl. Birmingham

Sponsor: Cytokinetics

Sex: All·Age: 18 - 85

Code: NCT04848506·Phase 2, Phase 3·Enrolling By Invitation

Sarcopenia Magnetic Resonance Imaging Evaluation (SUSIE)

for Sarcopenia

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 40+

Code: NCT04869813·Recruiting

Apply to this trial

Abatacept for the Treatment of Giant Cell Arteritis

for Giant Cell Arteritis

5 locations incl. Rochester

Sponsor: University of Pennsylvania

Sex: All·Age: 50+

Code: NCT04474847·Phase 3·Recruiting

Apply to this trial

A Study of AdAPT-001 in Subjects With Sarcoma and Refractory Solid Tumors

for Solid Tumor, Adult

6 locations incl. Duarte

Sponsor: EpicentRx, Inc.

Sex: All·Age: 18+

Code: NCT04673942·Phase 2·Recruiting

Apply to this trial

B-SAFER: Branched Stented Anastomosis Frozen Elephant Trunk Repair

for Thoracic Aortic Aneurysm

1 location in Cleveland

Sponsor: Eric Roselli, M. D.

Sex: All·Age: 18+

Code: NCT04747626·Recruiting

Apply to this trial

Physiologic Signals and Signatures With the Accuryn Monitoring System - The Accuryn Registry

for Intraabdominal Hypertension

9 locations incl. Los Angeles

Sponsor: Potrero Medical

Sex: All·Age: 18+

Code: NCT04669548·Recruiting

Apply to this trial

Parkinson's Foundation PD GENEration Genetic Registry

for Parkinson's Disease

54 locations incl. Birmingham

Sponsor: Parkinson's Foundation

Sex: All·Age: 18+

Code: NCT04994015·Recruiting

Apply to this trial

Nasal Outcomes Using Saline Irrigations After Endonasal Pituitary Surgery

for Pituitary Tumor

2 locations incl. Phoenix

Sponsor: Lori Wood

Sex: All·Age: 19 - 85

Code: NCT05659524·Recruiting

Apply to this trial

The MIRROR Registry: Minimally Invasive IntRaceRebral HemORrhage Evacuation

for Supratentorial Hemorrhage

20 locations incl. Burbank

Sponsor: Integra LifeSciences Corporation

Sex: All·Age: 18+

Code: NCT04494295·Recruiting

Apply to this trial