Sarcopenia Magnetic Resonance Imaging Evaluation (SUSIE)

Part of paid clinical trials in Cleveland, Ohio.

Sponsor
The Cleveland Clinic
Study ID
NCT04869813
Status
Recruiting
Apply to this trial

Conditions

  • Sarcopenia

Eligibility Criteria

Sex
ALL
Age
40 Years - N/A
Healthy Volunteers
Not accepted

Study Details

The goal of the proposed research is to investigate Magnetic Resonance (MR) Fingerprinting and P-MRS (Phosphorus-31 MR Spectroscopy) imaging for characterization of skeletal muscle in heart failure patients with sarcopenia. Heart failure patients with and without sarcopenia will be scanned using MR Fingerprinting and an existing Post-exercise phosphocreatine (PCr) recovery MR imaging protocol to obtain characteristic profiles of quantitative T1, T2, and PCr recovery rate.

Key Dates

Start date
Apr 9, 2021
Status verified
Feb 2026
Primary completion
Jun 30, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
70 participants (estimated)

Arms

  • Arm: Heart failure patients
    Inclusion criteria: * Age \> or = 40 yrs * Stable chronic heart failure * Systolic dysfunction determined by cardiac MRI with left ventricle ejection fraction 40% or less Exclusion criteria: • Advanced liver disease, advanced cancer, advanced chronic obstructive pulmonary disease Contraindications to MRI such as: * Heart pacemaker/defibrillator * Electronic/implanted stimulators or devices, including deep brain stimulator, vagus nerve stimulator, bladder stimulator, spine stimulator, neurostimulators; implanted electrodes or wires * Cochlear implant or other ear implants * Implanted drug pumps (insulin, narcotic/pain medications, drugs to treat spasticity) * Programmable shunt * Aneurysm clips and coils * Stents • Filters (for example, blood clot filters) * Metal fragment in body or eye (eg, BBs, bullets, shrapnel, metal pieces or shavings)
  • Arm: Healthy volunteers (Controls)
    Inclusion criteria: * Age \> or = 40 yrs * No diagnosed heart failure or sarcopenia Exclusion criteria • Advanced liver disease, advanced cancer, advanced chronic obstructive pulmonary disease Contraindications to MRI such as: * Heart pacemaker/defibrillator * Electronic/implanted stimulators or devices, including deep brain stimulator, vagus nerve stimulator, bladder stimulator, spine stimulator, neurostimulators; implanted electrodes or wires * Cochlear implant or other ear implants * Implanted drug pumps (insulin, narcotic/pain medications, drugs to treat spasticity) * Programmable shunt * Aneurysm clips and coils * Stents * Filters (for example, blood clot filters) * Metal fragment in body or eye (eg, BBs, bullets, shrapnel, metal pieces or shavings)

Primary Outcome Measure

Anticipated Results [ Time Frame: 3 years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Cleveland ClinicClevelandOhio44195
Tim Engelman, LPN
[email protected]
216-636-6153
Jen Wilcox, BA
[email protected]
216-636-6153
Brendan Eck, PhD (SUB_INVESTIGATOR)

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