Paid Clinical Trials in Chicago, IL

As of June 2026, 2,235 paid clinical trials are recruiting in Chicago, Illinois. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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2,235 clinical trials

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A Study of Weight Loss Intervention With Tirzepatide and Progestin Intrauterine Device to Treat Endometrial Hyperplasia and Grade 1 Endometrial Cancer

for Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia

Drug: Tirzepatide

3 locations incl. Chicago

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18+

Code: NCT07349641·Phase 2·Not Yet Recruiting

Effect of a Microprocessor-controlled Prosthetic Knee Joint on K2 Level Ambulators

for Transfemoral Amputation

2 locations incl. Chicago

Sponsor: VA Office of Research and Development

Sex: All·Age: 45 - 85

Code: NCT07103798·Not Yet Recruiting

Veterans' Intervention Blending NeuRomodulation and YogA for Chronic Low BackPaiN Treatment: VIBRANT

for Chronic Low Back Pain

2 locations incl. Chicago

Sponsor: VA Office of Research and Development

Sex: All·Age: 22+

Code: NCT07158567·Phase 3·Not Yet Recruiting

Testing the SurVaxM Vaccine for Lung Cancer Prevention

for Lung Carcinoma

Drug: SurVaxM

4 locations incl. Aurora

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07169617·Phase 2·Not Yet Recruiting

COMparison Between Anakinra and Tocilizumab in NORSE - "COMBAT-NORSE"

for New Onset Refractory Status Epilepticus

Drug: Tocilizumab

25 locations incl. Phoenix

Sponsor: Yale University

Sex: All·Age: 2+

Code: NCT07281027·Phase 3·Not Yet Recruiting

Implementation of AIP Services for Older Adults With AD

for Alzheimer Disease

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT07361601·Not Yet Recruiting

BRIDGE-US: Bridging Readiness in Deployed Neurotrauma Gaps for Excellence

for Brain Injuries, Acute

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 16+

Code: NCT07636213·Not Yet Recruiting

Aripiprazole in Body Focused Repetitive Behaviors

for Trichotillomania (Hair-Pulling Disorder)

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT05545891·Phase 2·Not Yet Recruiting

Ruxolitinib and Enzalutamide for the Treatment of Metastatic Castration-Resistant Prostate Cancer

for Castration-Resistant Prostate Carcinoma

Drug: Ruxolitinib

3 locations incl. Chicago

Sponsor: University of Michigan Rogel Cancer Center

Sex: Male·Age: 18+

Code: NCT06616155·Phase 1, Phase 2·Recruiting

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Study to Assess the Feasibility of Stopping Prostate Cancer Treatment Early in Elderly Patients

for Elderly

2 locations incl. Chicago

Sponsor: University of Chicago

Sex: Male·Age: 70+

Code: NCT06824818·Recruiting

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Study of the Pharmacokinetics and Safety of Glecaprevir/Pibrentasvir Initiated in Pregnancy in Women With Hepatitis C With and Without HIV

for Hepatitis C

Drug: Glecaprevir/pibrentasvir

10 locations incl. Los Angeles

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: Female·Age: 16 - 45

Code: NCT07040319·Phase 1, Phase 2·Recruiting

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A Study of LY4152199 in Participants With Previously Treated B-cell Malignancies (BAF_FRontier-1 )

for Lymphoma, Non-Hodgkin

23 locations incl. Duarte

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07101328·Phase 1·Not Yet Recruiting

RUSH Food is Medicine Veggie Rx - GusNIP Produce Prescription

for Food Insecurity

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18+

Code: NCT07376044·Not Yet Recruiting

Atebimetinib + GnP as a First Line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma

for Pancreatic Cancer

Drug: Atebimetinib

12 locations incl. Phoenix

Sponsor: Immuneering Corporation

Sex: All·Age: 18+

Code: NCT07562152·Phase 3·Recruiting

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Emsella for Reducing tSUI After HOLEP

for Benign Prostatic Hyperplasia

1 location in Chicago

Sponsor: Northwestern University

Sex: Male·Age: 50 - 80·Accepts healthy volunteers

Code: NCT07580404·Not Yet Recruiting

A Post-Market Assessment of the Safety and Performance of the TriClip™ System

for Tricuspid Regurgitation (TR)

2 locations incl. La Jolla

Sponsor: Abbott Medical Devices

Sex: All·Age: 18+

Code: NCT07586995·Enrolling By Invitation

A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight

for Overweight

Drug: Eloralintide

40 locations incl. The Villages

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 75

Code: NCT07589608·Phase 2·Not Yet Recruiting

VR Therapies for IBD

for Inflammatory Bowel Disease (IBD)

2 locations incl. Los Angeles

Sponsor: Brennan Spiegel

Sex: All·Age: 18+

Code: NCT07590518·Not Yet Recruiting

Parents and Babies Pilot

for Perinatal Depression

1 location in Chicago

Sponsor: Northwestern University

Sex: Female·Age: 18+

Code: NCT07607613·Not Yet Recruiting

A Study to Evaluate the Efficacy and Safety of Concomitant Use of Eplontersen and ALXN2220 Compared With Eplontersen and Placebo for Adults Participants With ATTR-CM

for Transthyretin Amyloid Cardiomyopathy (ATTR-CM)

24 locations incl. La Jolla

Sponsor: AstraZeneca

Sex: All·Age: 18 - 85

Code: NCT07608354·Phase 2·Not Yet Recruiting

An International Multicenter, Multivendor Evaluation of the Free-Running Framework for Cardiac Function

for Congenital Heart Diseases

9 locations incl. Los Angeles

Sponsor: Matthias Stuber

Sex: All·Age: All ages

Code: NCT07613398·Not Yet Recruiting

A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)

for Major Depressive Episode (MDE)

25 locations incl. Phoenix

Sponsor: Tonix Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT07621237·Phase 2·Recruiting

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Ejaculatory-Sparing HoLEP vs Standard HoLEP

for Enlarged Prostate (BPH)

1 location in Chicago

Sponsor: Northwestern University

Sex: Male·Age: 18 - 100·Accepts healthy volunteers

Code: NCT07631286·Recruiting

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Moses 2.0 vs Magneto for HoLEP - a Randomized Controlled Trial

for Enlarged Prostate (BPH)

1 location in Chicago

Sponsor: Northwestern University

Sex: Male·Age: 18 - 100·Accepts healthy volunteers

Code: NCT07632742·Recruiting

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A Study Evaluating the Immunotherapy Treatment for Ovarian Cancer and Other Advanced Malignancies.

for Ovarian Cancer

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT07389239·Phase 1, Phase 2·Not Yet Recruiting

A Study to Test Whether Nerandomilast Helps People With Systemic Sclerosis

for Systemic Sclerosis

Drug: Nerandomilast

30 locations incl. Birmingham

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT07497087·Phase 3·Not Yet Recruiting

Spiritual Care Intervention in Adult Patients Diagnosed With Acute Leukemia

for Leukemia

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT07405424·Recruiting

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A Study to Evaluate the Safety and Antiviral Activity of Two Human Monoclonal Antibodies (VRC07-523LS and PGT121.414.LS) During Analytic Treatment Interruption in Participants Living With HIV Who Initiated ART During Acute/Early HIV-1 Infection

for HIV-1-infection

10 locations incl. Birmingham

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 70

Code: NCT06987318·Phase 1·Not Yet Recruiting

A Research Study Comparing Different Ways of Increasing the Dose of NNC0662-0419 in Participants With Obesity

for Obesity

Drug: NNC0662-0419

24 locations incl. Montgomery

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07639021·Phase 2·Not Yet Recruiting

MINT Conditioning to Improve Gait

for Stroke

2 locations incl. Chicago

Sponsor: Northwestern University

Sex: All·Age: 18 - 85

Code: NCT07041775·Recruiting

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Developing a Digital Intervention for Adolescent Nonsuicidal Self-injury

for Nonsuicidal Self-injury

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 14 - 18

Code: NCT07224165·Recruiting

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A Study of Lirafugratinib in Non-CCA Solid Tumors With FGFR2 Fusion or Rearrangement

for FGFR2 Gene Fusion/Rearrangement

Drug: Lirafugratinib

7 locations incl. Phoenix

Sponsor: Elevar Therapeutics

Sex: All·Age: 18+

Code: NCT07359820·Phase 2·Recruiting

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GBPDC: Gut-Brain in PD Consortium Master Protocol

for Parkinson Disease (PD)

7 locations incl. Stanford

Sponsor: Duke University

Sex: All·Age: 21 - 80·Accepts healthy volunteers

Code: NCT07567794·Not Yet Recruiting

A RCT of Spectacles With Aspherical Lenslets or 0.05% Atropine for Myopia Control

for Myopia

12 locations incl. Birmingham

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 5 - 11

Code: NCT07095894·Phase 3·Recruiting

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PREcision MEDicine In Achalasia (PREMEDIA) - Cohort

for Type III Achalasia

13 locations incl. Scottsdale

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT07293689·Recruiting

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Maternal Outcomes: Mood, Alcohol Use, and Depressive Symptoms

for Postpartum Depression (PPD)

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: Female·Age: 18+

Code: NCT07485036·Not Yet Recruiting

Chicago Data-driven Opioid Use Disorder Screening, Engagement, Treatment and Planning System

for Opiod Use Disorder

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 16+·Accepts healthy volunteers

Code: NCT07498322·Not Yet Recruiting

A Phase 2 Clinical Study to Evaluate the Efficacy and Safety of Frevecitinib (KN-002) in Patients With Severe Asthma

for Severe Asthma

Drug: Frevecitinib

15 locations incl. Lancaster

Sponsor: Kinaset Therapeutics Inc

Sex: All·Age: 18 - 75

Code: NCT07532265·Phase 2·Not Yet Recruiting

Reversing InGuinal Hernia Trial: The Evaluation of Sex Hormones to Reverse Inguinal Hernias in Males

for Inguinal Hernia Unilateral

1 location in Chicago

Sponsor: Northwestern University

Sex: Male·Age: 50+

Code: NCT07604272·Phase 1·Not Yet Recruiting

Food and Metabolism Study

for Prediabetes

1 location in Chicago

Sponsor: Clinical Nutrition Research Center, Illinois Institute of Technology

Sex: All·Age: 40 - 70·Accepts healthy volunteers

Code: NCT07624500·Not Yet Recruiting