Clinical Trials at University of Chicago Medical Center

As of June 2026, 102 paid clinical trials are recruiting at University of Chicago Medical Center, located at 5841 S MARYLAND AVE, CHICAGO, IL 60637, phone (773) 702-0292 in Chicago, Illinois. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

Filter results

Filter results

State

City

Facility

Phase

Study type

Intervention

Recruitment status

Condition

Sex

Age

Healthy volunteers only

102 clinical trials at University of Chicago Medical Center

·Clear filters·↓ Download CSV

ENVISION IDE Trial: Safety and Effectiveness of NAVITOR in Transcatheter Aortic Valve Implantation

for Aortic Valve Stenosis

67 locations incl. Birmingham

Sponsor: Abbott Medical Devices

Sex: All·Age: 18+

Code: NCT05932615·Enrolling By Invitation

Changes in Glucose Tolerance in Patients With Cirrhosis Peri-Liver Transplant

for Cirrhosis, Liver

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 75

Code: NCT06950788·Recruiting

Apply to this trial

Exercise Strategies in Parkinson's Disease

for Parkinson Disease

7 locations incl. Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18 - 89

Code: NCT06104397·Enrolling By Invitation

The Society for Obstetric Anesthesia and Perinatology Research Network General Anesthesia Registry

for Cesarean Delivery

34 locations incl. Little Rock

Sponsor: Yale University

Sex: Female·Age: 15 - 55·Accepts healthy volunteers

Code: NCT06030063·Recruiting

Apply to this trial

An Evaluation of the AeriSeal System for CONVERTing Collateral Ventilation Status in Patients With Severe Emphysema

for Emphysema, Pulmonary

18 locations incl. Phoenix

Sponsor: Pulmonx Corporation

Sex: All·Age: 40 - 80

Code: NCT06035120·Recruiting

Apply to this trial

DCIS: RECAST Trial Ductal Carcinoma In Situ: Re-Evaluating Conditions for Active Surveillance Suitability as Treatment

for Ductal Carcinoma in Situ

28 locations incl. Berkeley

Sponsor: QuantumLeap Healthcare Collaborative

Sex: Female·Age: 18+

Code: NCT06075953·Phase 2·Recruiting

Apply to this trial

A Study of Valemetostat Tosylate in Combination With DXd ADCs in Subjects With Solid Tumors

for Advanced Solid Tumor

20 locations incl. Irvine

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT06244485·Phase 1·Recruiting

Apply to this trial

Combining Biomarkers and Electronic Risk Scores to Predict AKI in Hospitalized Patients

for Acute Kidney Injury

2 locations incl. Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT05988658·Recruiting

Apply to this trial

FT825/ONO-8250, an Off-the-Shelf, HER2 CAR-T, With or Without Monoclonal Antibodies in Advanced Solid Tumors

for Advanced Solid Tumor

14 locations incl. Gilbert

Sponsor: Fate Therapeutics

Sex: All·Age: 18+

Code: NCT06241456·Phase 1·Recruiting

Apply to this trial

Safety, PK, and Preliminary Efficacy of MBRC-101 in Advanced Refractory Solid Tumors

for Cancer

17 locations incl. San Francisco

Sponsor: MBrace Therapeutics

Sex: All·Age: 18+

Code: NCT06014658·Phase 1, Phase 2·Recruiting

Apply to this trial

Study of ISB 2001 in Relapsed/Refractory Multiple Myeloma (TRIgnite-1)

for Relapsed/Refractory Multiple Myeloma

10 locations incl. Palo Alto

Sponsor: Ichnos Sciences SA

Sex: All·Age: 18+

Code: NCT05862012·Phase 1·Recruiting

Apply to this trial

A Study of Enzalutamide, Enzalutamide in Combination With Mifepristone, or Chemotherapy in People With Metastatic Breast Cancer

for Metastatic Breast Cancer

12 locations incl. Birmingham

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT06099769·Phase 2·Recruiting

Apply to this trial

Seladelpar in Subjects With Primary Biliary Cholangitis (PBC) and Compensated Cirrhosis

for Primary Biliary Cholangitis

49 locations incl. Birmingham

Sponsor: Gilead Sciences

Sex: All·Age: 18+

Code: NCT06051617·Phase 3·Recruiting

Apply to this trial

Combination of GNS561 and Trametinib in Patients With Advanced KRAS Mutated Cholangiocarcinoma

for Cholangiocarcinoma

Drug: Trametinib

10 locations incl. Los Angeles

Sponsor: Genfit

Sex: All·Age: 18+

Code: NCT05874414·Phase 1, Phase 2·Recruiting

Apply to this trial

A Study of the Effect of ZT-01 on Night-time Hypoglycemia in Type 1 Diabetes

for Type 1 Diabetes Mellitus With Hypoglycemia

38 locations incl. Birmingham

Sponsor: Zucara Therapeutics Inc.

Sex: All·Age: 18 - 75

Code: NCT05762107·Phase 2·Recruiting

Apply to this trial

Pulmonary Embolism - Thrombus Removal With Catheter-Directed Therapy

for Pulmonary Embolism

40 locations incl. Birmingham

Sponsor: NYU Langone Health

Sex: All·Age: 18+

Code: NCT05591118·Phase 3·Recruiting

Apply to this trial

IPH5201 and Durvalumab in Patients With Resectable Non-Small Cell Lung Cancer (MATISSE)

for Non Small Cell Lung Cancer

Drug: Durvalumab

6 locations incl. St. Petersburg

Sponsor: Innate Pharma

Sex: All·Age: 18+

Code: NCT05742607·Phase 2·Recruiting

Apply to this trial

Interactive Computer-adaptive Chronic Kidney Disease Education Program

for Chronic Kidney Diseases

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 70

Code: NCT06364358·Recruiting

Apply to this trial

Study of Cabozantinib and Nivolumab in Metastatic Castration Resistant Prostate Cancer

for Castration-resistant Prostate Cancer

Drug: Cabozantinib

4 locations incl. La Jolla

Sponsor: Rana McKay, MD

Sex: Male·Age: 18+

Code: NCT05502315·Phase 2·Recruiting

Apply to this trial

GI Oxalate Absorption

for Bariatric Surgery Candidate

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 70

Code: NCT05356000·Recruiting

Apply to this trial

Basic Experimental Study of Hippocampal Memory Functions

for Memory

2 locations incl. Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT05945628·Enrolling By Invitation

At-home Walking Cadence Functional Assessment and Recovery Trajectory for Older Adults Undergoing Major Surgery

for Gait, Unsteady

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 60+

Code: NCT05886725·Recruiting

Apply to this trial

Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services

for Schizophrenia Spectrum and Other Psychotic Disorders

6 locations incl. Hartford

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18 - 40

Code: NCT06740383·Recruiting

Apply to this trial

A Study to Evaluate Etrasimod Treatment in Adolescents With Ulcerative Colitis

for Ulcerative Colitis

20 locations incl. Little Rock

Sponsor: Pfizer

Sex: All·Age: 12 - 17

Code: NCT05287126·Phase 2·Recruiting

Apply to this trial

Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)

for Triple Negative Breast Cancer

184 locations incl. Birmingham

Sponsor: Gilead Sciences

Sex: All·Age: 18+

Code: NCT05633654·Phase 3·Recruiting

Apply to this trial

Oxalate and Citrate

for Kidney Stone

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT05334979·Recruiting

Apply to this trial

Anti-inflammatory Drugs and Serum Prostate-Specific Antigen Test

for Prostate Cancer

3 locations incl. Chicago

Sponsor: Albany Medical College

Sex: Male·Age: 18 - 80

Code: NCT05629494·Phase 4·Recruiting

Apply to this trial

Study of JANX007 in Subjects With Metastatic Castration-Resistant Prostate Cancer (ENGAGER-PSMA-01)

for Prostate Cancer

32 locations incl. Birmingham

Sponsor: Janux Therapeutics

Sex: Male·Age: 18 - 100

Code: NCT05519449·Phase 1·Recruiting

Apply to this trial

A Study of Neladalkib (NVL-655) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ALK Rearrangement or Activating ALK Mutation (ALKOVE-1)

for Locally Advanced Solid Tumor

21 locations incl. Orange

Sponsor: Nuvalent Inc.

Sex: All·Age: 12+

Code: NCT05384626·Phase 1, Phase 2·Recruiting

Apply to this trial

A Study of Disitamab Vedotin Alone or With Pembrolizumab in Urothelial Cancer That Expresses HER2

for Urothelial Carcinoma

159 locations incl. Gilbert

Sponsor: Seagen, a wholly owned subsidiary of Pfizer

Sex: All·Age: 18+

Code: NCT04879329·Phase 2·Recruiting

Apply to this trial

EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Years of Age With COVID-19 That Are Not Hospitalized But Are at Risk for Severe Disease

for COVID-19

50 locations incl. Phoenix

Sponsor: Pfizer

Sex: All·Age: 0 - 17

Code: NCT05261139·Phase 3·Recruiting

Apply to this trial

Diabetic Neuropathy in Spinal Cord Stimulator Patients

for Diabetes Mellitus

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT04687215·Recruiting

Apply to this trial

First-in-Human Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, as a Single Agent in Patients With Advanced Solid Tumors and in Combination With Endocrine Therapy +/- a CDK4/6 or CDK4 Inhibitor in Patients With Advanced Solid Tumors or Advanced Breast Cancer

for PIK3CA Mutation

24 locations incl. Tucson

Sponsor: Relay Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05216432·Phase 1·Recruiting

Apply to this trial

Safety of SBRT With Anti-PD1 and Anti-IL-8 for the Treatment of Multiple Metastases in Advanced Solid Tumors and Melanoma

for Melanoma

2 locations incl. Chicago

Sponsor: Yana Najjar

Sex: All·Age: 18+

Code: NCT04572451·Phase 1·Recruiting

Apply to this trial

A Phase 1b/2 Study of Sonrotoclax (BGB-11417) as Monotherapy and in Various Combinations With Dexamethasone Plus Carfilzomib, Dexamethasone Plus Daratumumab, and Dexamethasone Plus Pomalidomide in Multiple Myeloma

for Relapsed/Refractory Multiple Myeloma

Drug: Daratumumab

16 locations incl. Birmingham

Sponsor: BeOne Medicines

Sex: All·Age: 18+

Code: NCT04973605·Phase 1, Phase 2·Recruiting

Apply to this trial

A Study of 177Lu-FAP-2286 in Advanced Solid Tumors

for Solid Tumor

20 locations incl. Birmingham

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18+

Code: NCT04939610·Phase 1, Phase 2·Recruiting

Apply to this trial

Connect for Cancer Prevention Study (Connect)

for Cancer

10 locations incl. Denver

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 30 - 70·Accepts healthy volunteers

Code: NCT04609072·Recruiting

Apply to this trial

Avo In R/R And Previously Untreated MCL

for Mantle Cell Lymphoma

3 locations incl. Chicago

Sponsor: Austin I Kim

Sex: All·Age: 18+

Code: NCT04855695·Phase 1, Phase 2·Recruiting

Apply to this trial

Low Dose ColchicinE in pAtients With Peripheral Artery DiseasE to Address Residual Vascular Risk

for Peripheral Arterial Disease

19 locations incl. New Haven

Sponsor: Population Health Research Institute

Sex: All·Age: 18+

Code: NCT04774159·Phase 3·Recruiting

Apply to this trial

Effect on Body Movement and Mental Skills in Patients Who Received Gadolinium-based Contrast Media for Magnetic Resonance Examination Multiple Times Within 5 Years

for Motor Function

16 locations incl. Scottsdale

Sponsor: Guerbet

Sex: All·Age: 18 - 64

Code: NCT04373564·Phase 4·Recruiting

Apply to this trial