Oxalate and Citrate

Part of paid clinical trials in Chicago, Illinois.

Sponsor
University of Chicago
Study ID
NCT05334979
Status
Recruiting
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Conditions

  • Kidney Stone
  • Normal Controls

Eligibility Criteria

Sex
ALL
Age
18 Years - 70 Years
Healthy Volunteers
Accepted

Interventions

  • Kidney stones Normal controls Consuming a special drink (sodium oxalate) during an all day visit to the University of Chicago research clinic — OTHER
    Consuming a special drink (sodium oxalate) during an all day visit to the University of Chicago research clinic Subjects in both arms will be asked to partake in the same activities, as follows: The day before presenting to the research clinic subjects will collect urine at home. Subjects will will come in to the research clinic at the University of Chicago in Hyde Park, where they will spend most of the day. We will give them a special liquid that contains oxalate, and they will receive a specially prepared breakfast that is low in oxalate and citrate. After this, we will collect urine and blood throughout the day. While at the clinic, subjects will also receive specially prepared snacks.

Study Details

This is a single-center study that aims to earn more about how two different compounds found in food, oxalate and citrate, may affect a person's chances of forming kidney stones.

Key Dates

Start date
Oct 27, 2022
Status verified
Jan 2026
Primary completion
Dec 1, 2026
Completion
Dec 1, 2026

Study Design

Enrollment
50 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION

Arms

  • Other: Kidney stone formers
    25 stone-forming subjects will be enrolled in this arm.
  • Other: Non-kidney stone formers
    25 non-stone-forming subjects will be enrolled in this arm.

Primary Outcome Measure

Change in concentration of urine oxalate from baseline to 2-hours, 4-hours, and 6-hours after sodium oxalate consumption [ Time Frame: 6 hours ]

Locations (1)

FacilityCityStateZIPSite coordinators
University of Chicago Medical CenterChicagoIllinois60637
Megan Prochaska, MD
[email protected]
(773) 702-1000
Megan Prochaska, MD (PRINCIPAL_INVESTIGATOR)

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By research site
University of Chicago Medical Center· Chicago, IL

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