Kidney Stone Inflammation

Part of paid clinical trials in Chicago, Illinois.

Sponsor
University of Chicago
Study ID
NCT06436235
Status
Recruiting
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Conditions

  • Kidney Stone
  • Stone, Kidney

Eligibility Criteria

Sex
ALL
Age
18 Years - 70 Years
Healthy Volunteers
Accepted

Study Details

This observational study aims to look at the connections between kidney stones, insulin resistance, and inflammation. The researchers hypothesize that people who form calcium kidney stones and have insulin resistance may have higher levels of inflammation because they have more visceral fat (fat around the abdominal organs). The study will recruit 20 people who have had calcium kidney stones but don't have diabetes, and 20 healthy people who haven't had kidney stones. All the participants will come to the research center at the University of Chicago Medicine. Participants will have a dual-energy X-ray absorptiometry (DEXA) scan to measure their visceral fat, and give blood and urine samples. The blood will be tested for insulin resistance, inflammatory markers, and other metabolic factors. The urine will be analyzed for substances that increase kidney stone risk. The main goal is to see if the kidney stone formers with insulin resistance have more visceral fat compared to those without insulin resistance and the healthy participants. The researchers will also compare inflammatory marker levels between groups, and look at how visceral fat, inflammatory markers, insulin resistance, and urine stone risk factors are related. The findings may help explain how kidney stones are connected to metabolic conditions like diabetes and cardiovascular disease. Researchers hope this information will help identify stone formers at risk early and develop preventive treatments in the future.

Key Dates

Start date
Jun 30, 2024
Status verified
Sep 2025
Primary completion
May 1, 2026
Completion
Aug 1, 2026

Study Design

Enrollment
40 participants (estimated)

Arms

  • Arm: Kidney stone formers
    The study team plans to enroll 20 non-diabetic participants with a history of at least one calcium-based kidney stone. Activities are the same for both cohorts, as follows: * Before clinic visit, participants will halt specific supplements and diuretics for a week. * At home, they complete a dietary questionnaire and collect 24-hour urine. * On the 7th day, they visit University of Chicago CRC. There, investigators will take measurements (height, weight) and DEXA scan, alongside kidney stone history review. * Throughout the day, participants provide urine and blood samples, undergo blood pressure checks, and fast until sample collection. * Samples undergo testing for kidney stone, inflammation, and diabetes risk factors and are stored for future research.
  • Arm: Control cohort
    The study team plans to enroll 20 healthy control participants with no history of kidney stones or family history of kidney stones. Activities are the same for both cohorts, as follows: * Before clinic visit, participants will halt specific supplements and diuretics for a week. * At home, they complete a dietary questionnaire and collect 24-hour urine. * On the 7th day, they visit University of Chicago CRC. There, investigators will take measurements (height, weight) and DEXA scan, alongside kidney stone history review. * Throughout the day, participants provide urine and blood samples, undergo blood pressure checks, and fast until sample collection. * Samples undergo testing for kidney stone, inflammation, and diabetes risk factors and are stored for future research.

Primary Outcome Measure

Difference in visceral fat content in participants who form kidney stones with insulin resistance compared to participants who form kidney stones without insulin resistance and controls [ Time Frame: 1 week total, one half day in the CRC ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Chicago Medical CenterChicagoIllinois60637
Megan Prochaska, MD
[email protected]
773-702-1000
Megan Prochaska, MD (PRINCIPAL_INVESTIGATOR)

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By research site
University of Chicago Medical Center· Chicago, IL

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