Oxalate and Citrate in Humans - Response to Citrate

Part of paid clinical trials in Chicago, Illinois.

Sponsor
University of Chicago
Study ID
NCT06944223
Status
Recruiting
Apply to this trial

Conditions

  • Healthy
  • Kidney Stone

Eligibility Criteria

Sex
ALL
Age
18 Years - 70 Years
Healthy Volunteers
Accepted

Interventions

  • Kidney stone formers — OTHER
    Consuming a special drink (potassium citrate) during an all-day visit to the University of Chicago research clinic Subjects in both groups will be asked to partake in the same activities, as follows: The day before presenting to the research clinic, subjects will collect urine at home. Subjects will then come to the research clinic at the University of Chicago in Hyde Park, where they will spend most of the day. We will give them a special liquid that contains potassium citrate. After this, we will collect urine and blood samples throughout the day. While at the clinic, subjects will also receive a boxed lunch at the end of the visit.
  • Control cohort — OTHER
    Consuming a special drink (potassium citrate) during an all-day visit to the University of Chicago research clinic Subjects in both groups will be asked to partake in the same activities, as follows: The day before presenting to the research clinic, subjects will collect urine at home. Subjects will then come to the research clinic at the University of Chicago in Hyde Park, where they will spend most of the day. We will give them a special liquid that contains potassium citrate. After this, we will collect urine and blood samples throughout the day. While at the clinic, subjects will also receive a boxed lunch at the end of the visit.

Study Details

This is a single-center study that aims to learn more about how two compounds found in food, oxalate and citrate, interact in the body and may influence a person's chances of forming kidney stones. The study will examine changes in urinary oxalate and citrate levels after participants consume potassium citrate.

Key Dates

Start date
Oct 1, 2025
Status verified
Dec 2025
Primary completion
Dec 1, 2026
Completion
Jun 1, 2027

Study Design

Enrollment
24 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Other: Kidney stone formers
    12 stone-forming subjects will be enrolled in this arm.
  • Other: Control cohort
    12 non-stone-forming subjects will be enrolled in this arm.

Primary Outcome Measure

Change in urine oxalate from baseline to 2-hours, 4-hours, and 6-hours after potassium citrate consumption. [ Time Frame: 6 hours ]

Locations (1)

FacilityCityStateZIPSite coordinators
University of Chicago Medical CenterChicagoIllinois60637
Megan Prochaska, MD
[email protected]
773-702-1000

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By research site
University of Chicago Medical Center· Chicago, IL

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