Paid Clinical Trials in Charlotte, NC

As of June 2026, 556 paid clinical trials are recruiting in Charlotte, North Carolina. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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556 clinical trials

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A Study to Assess the Safety and Efficacy of Different Doses of ELV001 to Treat Active Rheumatoid Arthritis in Patients With an Inadequate Response to Methotrexate and Tumor Necrosis Factor Inhibition (START SYNERGY)

for Active Rheumatoid Arthritis

22 locations incl. Gilbert

Sponsor: Elevara Medicines Limited

Sex: All·Age: 18 - 75

Code: NCT07409103·Phase 2·Recruiting

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A Study to Assess the Effectiveness and Safety of IPN10200 Over Time in Adults With Moderate to Severe Wrinkle-like Lines Between the Eyebrows

for Moderate to Severe Glabellar Lines

41 locations incl. Los Angeles

Sponsor: Ipsen

Sex: All·Age: 18 - 80

Code: NCT07435428·Phase 3·Recruiting

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A Novel Dialectical Behavior Therapy Brief Group Intervention for Cigarette Smoking by Patients With Cancer: An Open Clinical Trial

for Smoking Behavior

2 locations incl. Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT07119489·Recruiting

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A Phase 2b Study Evaluating Oral VH4524184 Regimens in Treatment Naïve Persons With HIV-1 (INNOVATE Study)

for HIV Infections

32 locations incl. Bakersfield

Sponsor: ViiV Healthcare

Sex: All·Age: 18+

Code: NCT07202546·Phase 2·Recruiting

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A Double-blind, Randomized Controlled Trial to Investigate the Efficacy, Safety, and Pharmacokinetics of Pegloticase Administration Via Subcutaneous and Intravenous Routes Both With Methotrexate in Participants With Uncontrolled Gout

for Uncontrolled Gout

48 locations incl. Birmingham

Sponsor: Amgen

Sex: All·Age: 18+

Code: NCT07388498·Phase 3·Recruiting

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A Study to Develop a Blood-based Test for Aiding the Diagnosis/Prognosis of Traumatic Brain Injury in Adults and for Monitoring the Development of Secondary Events in Patients Diagnosed With Traumatic Brain Injury

for Traumatic Brain Injury

13 locations incl. Sacramento

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT07455136·Recruiting

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Prophylactic TBR on Phantom Limb Pain

for Phantom Limb Pain After Amputation

1 location in Charlotte

Sponsor: OrthoCarolina Research Institute, Inc.

Sex: All·Age: 13+

Code: NCT06956508·Enrolling By Invitation

Metastatic Ewing's Trial Testing Schedule Enhancement to Improve Outcomes

for Metastatic Ewing Sarcoma

17 locations incl. Birmingham

Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Sex: All·Age: 1+

Code: NCT07194044·Phase 1·Recruiting

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Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2

for Gastric Cancer

Drug: Sonesitatug vedotin

77 locations incl. Phoenix

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07431281·Phase 3·Recruiting

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Study to Evaluate the REMEDY SPECTRUM GV IM Spacer Nail in the Treatment of Ankle-Related Infections

for Periprosthetic Joint Infection

3 locations incl. Lansing

Sponsor: OsteoRemedies, LLC

Sex: All·Age: 21+·Accepts healthy volunteers

Code: NCT06428448·Phase 2·Recruiting

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Phase 2 Study of Disease Risk Mutation-Guided Finite Acalabrutinib+Venetoclax for Relapsed CLL Post-1L Finite cBTKi+BCL2i ± Obinutuzumab

for Chronic Lymphocytic Leukemia (CLL)

Drug: Venetoclax

3 locations incl. Boston

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT07024706·Phase 2·Not Yet Recruiting

Study to Evaluate the Safety and Efficacy of Larsucosterol in Participants With Alcohol-associated Hepatitis (AH)

for Hepatitis

Drug: Larsucosterol

48 locations incl. Birmingham

Sponsor: Bausch Health Americas, Inc.

Sex: All·Age: 18+

Code: NCT07428538·Phase 3·Recruiting

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ONC-MM-2407: The Effect of Virtual Reality Headsets on Pain and Anxiety in the Peri and Post Bone Marrow Biopsy Period

for Hematologic Malignancy

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT07203534·Recruiting

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Inobrodib, Pomalidomide and Dexamethasone in Relapsed or Refractory Multiple Myeloma

for Multiple Myeloma Refractory

12 locations incl. San Francisco

Sponsor: CellCentric Ltd.

Sex: All·Age: 18+

Code: NCT07096778·Phase 2·Recruiting

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Beamion LUNG-3: Adjuvant Zongertinib vs Standard Treatment in People With Completely Resected Stage II-IIIB NSCLC Harboring Activating HER2 TKD Mutations

for Non-small Cell Lung Cancer

29 locations incl. Fresno

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT07195695·Phase 3·Recruiting

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Digoxin Medulloblastoma Study

for Medulloblastoma

15 locations incl. Birmingham

Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Sex: All·Age: 12 Months - 30

Code: NCT06701812·Phase 2·Recruiting

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A Study to Evaluate the Efficacy and Safety of JNJ-88545223 for the Treatment of Participants With Active Psoriatic Arthritis

for Arthritis, Psoriatic

16 locations incl. Searcy

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT07321873·Phase 2·Recruiting

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Non-inferiority Study of Frexalimab Subcutaneous Administration Compared to Intravenous Administration in Adult Participants With Multiple Sclerosis

for Multiple Sclerosis

Drug: Frexalimab

21 locations incl. Cullman

Sponsor: Sanofi

Sex: All·Age: 18 - 60

Code: NCT07325292·Phase 3·Recruiting

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A 26-Wk Study to Assess Safety & Efficacy of Tenapanor for T/t of Chronic Idiopathic Constipation in Adults

for Chronic Idiopathic Constipation (CIC)

Drug: Tenapanor

109 locations incl. Foley

Sponsor: Ardelyx

Sex: All·Age: 18 - 80

Code: NCT07382167·Phase 3·Recruiting

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A Study of Migalastat in Pediatric Subjects (2 to <12 Yrs) With Fabry Disease and Amenable GLA Variants

for Fabry Disease

6 locations incl. Atlanta

Sponsor: Amicus Therapeutics

Sex: All·Age: 2 - 11

Code: NCT06904261·Phase 3·Recruiting

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Supraglottic Airway for Resuscitation Trial

for Neonatal Resuscitation

30 locations incl. Birmingham

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 0 Days+

Code: NCT07150923·Recruiting

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A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer

for Untreated, Unresectable, or Metastatic Colorectal Cancer

Drug: Bevacizumab

49 locations incl. Tucson

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07221357·Phase 2, Phase 3·Recruiting

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Diagnosing Epilepsy To EffeCT Change

for Epilepsy

18 locations incl. Phoenix

Sponsor: Epiminder America, Inc.

Sex: All·Age: 18 - 75

Code: NCT07110337·Recruiting

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A Clinical Study of Islatravir and Ulonivirine for People With HIV-1 Who Have Not Been Treated Before (MK-8591B-062)

for Human Immunodeficiency Virus Type 1 (HIV-1) Infection

24 locations incl. Los Angeles

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT07266831·Phase 2, Phase 3·Recruiting

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A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract

for Carcinoma, Transitional Cell

60 locations incl. Huntsville

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07218380·Phase 3·Recruiting

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Testing an Enhanced Digital Delivery Model for Inherited Cancer Genetic Testing in Young Adults With Cancer

for Miscellaneous Neoplasm, Nos

231 locations incl. Anchorage

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07091617·Recruiting

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Study to Evaluate INCB123667 Versus Investigator's Choice of Chemotherapy in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression

for Ovarian Cancer

Drug: INCB123667

29 locations incl. Anchorage

Sponsor: Incyte Corporation

Sex: Female·Age: 18+

Code: NCT07214779·Phase 3·Recruiting

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A Study to Evaluate LY3537021 for the Treatment of Nausea and Vomiting Caused by Chemotherapy in Adults With Cancer

for Nausea

19 locations incl. Greenbrae

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07169851·Phase 2·Recruiting

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A Study to Evaluate the Efficacy and Safety of Cannabidiol Oral Solution (CBD-OS [GWP42003-P, JZP926]) for the Treatment of Focal-Onset Seizures

for Focal Seizures

24 locations incl. Phoenix

Sponsor: Jazz Pharmaceuticals

Sex: All·Age: 12 - 75

Code: NCT07233239·Phase 1·Recruiting

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A Prospective, Randomized, Single-blind, Controlled, Multi-center Study to Assess the Safety and Performance of MagnetOsTM Compared to Autogenous Bone Graft in Patients Undergoing Hindfoot or Ankle Fusions.

for Ankle Arthrodesis or Arthroplasty

5 locations incl. Vail

Sponsor: Kuros Biosurgery AG

Sex: All·Age: 18 - 75

Code: NCT07225751·Recruiting

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Zymfentra (Infliximab-dyyb) REal World Cohort STudy

for Ulcerative Colitis (UC)

9 locations incl. New Haven

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+

Code: NCT07237516·Recruiting

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R.E.C.K vs Exparel in Robotic Nephrectomy

for Renal Carcinoma

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT07092566·Phase 3·Recruiting

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A Study to Evaluate the Long-term Safety, Tolerability, and Efficacy of Subcutaneous Sonelokimab in Participants With Psoriatic Arthritis

for Arthritis, Psoriatic

16 locations incl. Avondale

Sponsor: MoonLake Immunotherapeutics AG

Sex: All·Age: 18+

Code: NCT07223138·Phase 3·Enrolling By Invitation

A 16-Week Study to Learn About the Study Medicine Called Ritlecitinib in Adults With Long Lasting Painful Red Skin Lumps, Known by the Medical Term, Hidradenitis Suppurativa, or HS.

for Hidradenitis Suppurativa

Drug: Ritlecitinib

32 locations incl. Phoenix

Sponsor: Pfizer

Sex: All·Age: 18 - 75

Code: NCT07228390·Phase 2·Recruiting

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Phase III Study to Assess the Safety and Efficacy of SL1002 for Osteoarthritis Knee Pain

for Osteoarthritis Knee Pain

20 locations incl. San Diego

Sponsor: Saol Therapeutics Inc

Sex: All·Age: 40+

Code: NCT07226258·Phase 3·Recruiting

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Comparison of Urinary Flow Study

for Urinary Retention

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: Female·Age: 18+

Code: NCT06918067·Recruiting

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Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer

for Locally Advanced Cervical Adenocarcinoma

260 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18+

Code: NCT07061977·Phase 3·Recruiting

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COMPARE - Pediatric Inflammatory Bowel Disease (PIBD)

for Ulcerative Colitis, Pediatric

4 locations incl. Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 1 - 18

Code: NCT07198113·Recruiting

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Human Menopausal Gonadotropin Research in Infertility Assessing Cumulative Live Birth With Frozen Embryo Transfer.

for Infertility (IVF Patients)

16 locations incl. Encino

Sponsor: Granata Bio Corporation

Sex: Female·Age: 18 - 42

Code: NCT07216742·Phase 3·Recruiting

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A Study of Modified Release RTN-001 In Patients With Uncontrolled Hypertension

for Uncontrolled Hypertension

20 locations incl. San Jose

Sponsor: Retension Pharmaceuticals. Inc.

Sex: All·Age: 18 - 70

Code: NCT07142356·Phase 2·Recruiting

Apply to this trial