A Study to Evaluate the Efficacy and Safety of JNJ-88545223 for the Treatment of Participants With Active Psoriatic Arthritis

Part of paid clinical trials in Searcy, Arkansas.

Sponsor
Janssen Research & Development, LLC
Study ID
NCT07321873
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

  • Arthritis, Psoriatic

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • JNJ-88545223 — DRUG
    JNJ-88545223 will be administered.
  • Placebo — DRUG
    Placebo will be administered.

Study Details

The purpose of this study is to evaluate how well the study drug JNJ-88545223 works compared with a placebo (an inactive substance) in adults with active psoriatic arthritis (PsA). The study aims to see whether treatment with JNJ-88545223 can help reduce the signs and symptoms of PsA and improve joint and skin health.

Key Dates

Start date
Jan 15, 2026
Status verified
Jun 2026
Primary completion
Jun 28, 2027
Completion
Aug 2, 2027

Study Design

Enrollment
240 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Placebo Comparator: Arm 1: Placebo
    Participants will receive matching placebo to JNJ-88545223, from Week 0 to Week 16.
  • Experimental: Arm 2: JNJ-88545223 Dose 1
    Participants will receive JNJ-88545223 Dose 1 from Week 0 to Week 16.
  • Experimental: Arm 3: JNJ-88545223 Dose 2
    Participants will receive JNJ-88545223 Dose 2 from Week 0 to Week 16.
  • Experimental: Arm 4: JNJ-88545223 Dose 3
    Participants will receive JNJ-88545223 Dose 3 from Week 0 to Week 16.

Primary Outcome Measure

Proportion of Participants who Achieved an American College of Rheumatology (ACR) 50 Response at Week 16 [ Time Frame: Week 16 ]

Central Contacts

Locations (16)

FacilityCityStateZIPSite coordinators
Unity Health-White County Medical CenterSearcyArkansas72143-
Newport Huntington Medical GroupHuntington BeachCalifornia92648-
Rheumatology Center of San DiegoSan DiegoCalifornia92128-
American Research, LLCCutler BayFlorida33157-
Innovation Medical Research CenterPalmetto BayFlorida33157-
Integral Rheumatology And Immunology SpecialistsPlantationFlorida33324-
Clinical Research of West FloridaTampaFlorida33606-
Conquest ResearchWinter ParkFlorida32789-
Atlanta Research Center for RheumatologyMariettaGeorgia30060-
Willow Rheumatology and Wellness PLLCWillowbrookIllinois60527-
Qualmedica ResearchEvansvilleIndiana47715-
Albuquerque Rehabilitation and RheumatologyAlbuquerqueNew Mexico87102-
Joint and Muscle Research InstituteCharlotteNorth Carolina28204-
Paramount Medical Research & ConsultingMiddleburg HeightsOhio44130-
Clinical Research PhiladelphiaPhiladelphiaPennsylvania19114-
Arthritis and Rheumatology Research InstituteAllenTexas75013-

Find similar trials in Searcy, AR

By research site
Unity Health-White County Medical Center· Searcy, ARNewport Huntington Medical Group· Huntington Beach, CARheumatology Center of San Diego· San Diego, CAAmerican Research, LLC· Cutler Bay, FLInnovation Medical Research Center· Palmetto Bay, FLIntegral Rheumatology And Immunology Specialists· Plantation, FL

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