Paid Clinical Trials in Charleston, SC

As of June 2026, 721 paid clinical trials are recruiting in Charleston, South Carolina. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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721 clinical trials

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Prenatally-initiated Psychological Intervention for Mothers of Infants With Congenital Heart Disease (CHD)

for Congenital Heart Disease (CHD)

17 locations incl. Phoenix

Sponsor: Carelon Research

Sex: All·Age: 18+

Code: NCT07582861·Not Yet Recruiting

Open-Label Safety Study of AXS-14 in Subjects With Fibromyalgia

for Fibromyalgia

8 locations incl. Santa Ana

Sponsor: Axsome Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07637162·Phase 3·Enrolling By Invitation

Sex Differences in Neurobehavioral Response to THC

for Cannabis Use Disorder

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 21 - 45

Code: NCT07225777·Phase 2·Recruiting

Apply to this trial

Direct vs Standard SLT for Glaucoma: A Noninferiority Trial

for Open-angle Glaucoma (OAG)

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07408154·Recruiting

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Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck Cancer

for Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8

51 locations incl. Tucson

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07195734·Phase 2·Recruiting

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A Study of TSRA-196 in Adults With PiZZ Alpha-1 Antitrypsin Deficiency (AATD)

for Alpha-1 Antitrypsin Deficiency (AATD)

2 locations incl. Boston

Sponsor: Tessera Therapeutics, Inc.

Sex: All·Age: 18 - 70

Code: NCT07227207·Phase 1, Phase 2·Recruiting

Apply to this trial

Add-On ZIDA Sock Therapy for Overactive Bladder

for Overactive Bladder

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07432659·Recruiting

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A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma

for Solid Tumors

Drug: INCB161734

68 locations incl. Birmingham

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT07522073·Phase 3·Recruiting

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Evaluating NALIRIFOX vs Modified Gemcitabine, Nab-Paclitaxel and Cisplatin in Patients With Locally Advanced and Metastatic Pancreatic Adenocarcinoma

for Metastatic Pancreatic Adenocarcinoma

2 locations incl. Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07076212·Phase 2·Recruiting

Apply to this trial

Atomoxetine and Executive Function in PTSD

for Posttraumatic Stress Disorder With Attention Defic

1 location in Charleston

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT06573970·Phase 4·Not Yet Recruiting

Mindfulness Training During Accelerated TMS for Depression

for Depression

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 80

Code: NCT07369557·Not Yet Recruiting

At-home taVNS for Neurorehabilitation in Parkinson's Disease

for Parkinson's Disease

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 40 - 85

Code: NCT07536022·Not Yet Recruiting

A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)

for Macular Degeneration

30 locations incl. Springdale

Sponsor: EyeBiotech Ltd.

Sex: All·Age: 50+

Code: NCT07440225·Phase 2, Phase 3·Recruiting

Apply to this trial

A Study to Evaluate the Safety, Tolerability, and Efficacy of Pumitamig Alone or in Combination With Ipilimumab or Cabozantinib in Participants With Advanced Renal Cell Carcinoma (RCC) (ROSETTA RCC-208)

for Advanced Renal Cell Carcinoma (RCC)

Drug: Cabozantinib

13 locations incl. New Haven

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07293351·Phase 1, Phase 2·Recruiting

Apply to this trial

LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis

for Ulcerative Colitis (UC)

Drug: LY4268989

49 locations incl. Phoenix

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 80

Code: NCT07415044·Phase 2·Recruiting

Apply to this trial

Advanced Fibrosis Detection for MASLD in Primary Care

for Metabolic Dysfunction-associated Steatotic Liver Disease

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07159386·Recruiting

Apply to this trial

Brain Stimulation and Cognitive Training for MCI

for Mild Cognitive Impairment (MCI)

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 60 - 85

Code: NCT07526740·Recruiting

Apply to this trial

Cannabis Reduction and Functional Outcomes

for Cannabis Use Disorder

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07218471·Recruiting

Apply to this trial

Long-Term Open-Label Extension Study of Oral Levosimendan

for Pulmonary Hypertension Associated With HFpEF

5 locations incl. Chicago

Sponsor: Tenax Therapeutics, Inc.

Sex: All·Age: All ages

Code: NCT07436689·Phase 3·Enrolling By Invitation

taVNS + CCT for Neurocognitive Rehab

for Psychosocial Well-being

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 45 - 80

Code: NCT07517237·Recruiting

Apply to this trial

Evaluating ER-100 for Safety in People With Glaucoma or Non-Arteritic Anterior Ischemic Optic Neuropathy (Optic Nerve Conditions)

for Open Angle Glaucoma (OAG)

4 locations incl. Glendale

Sponsor: Life Biosciences Inc.

Sex: All·Age: 40 - 85

Code: NCT07290244·Phase 1·Recruiting

Apply to this trial

Simeox 200 US Study

for Bronchiectasis

1 location in Charleston

Sponsor: Inogen Inc.

Sex: All·Age: 18 - 85

Code: NCT07443124·Not Yet Recruiting

A Study to Test Whether BI 3802876 is Tolerated in People With Compensated Liver Cirrhosis Due to Metabolic Dysfunction- Associated Steatohepatitis (MASH)

for Liver Cirrhosis

Drug: BI 3802876

26 locations incl. Chandler

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18 - 75

Code: NCT07325526·Phase 2·Recruiting

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A Study to Assess the Effectiveness and Safety of IPN10200 in Adults With Moderate to Severe Wrinkle-like Lines Between the Eyebrows

for Moderate to Severe Glabellar Lines

17 locations incl. Birmingham

Sponsor: Ipsen

Sex: All·Age: 18 - 80

Code: NCT07427797·Phase 3·Recruiting

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AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight

for Obesity

Drug: NNC0487-0111

22 locations incl. Miramar

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07339423·Phase 3·Recruiting

Apply to this trial

REVEAL Study - Diagnostic Testing for PTSD Using the Senseye Diagnostic Tool

for PTSD - Post Traumatic Stress Disorder

5 locations incl. Aurora

Sponsor: Senseye, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07280065·Phase 3·Recruiting

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A Study Comparing AZD0120, a Dual-targeted CAR-T Against B-cell Maturation Antigen (BCMA) and CD19, Versus Standard Regimens in Participants With Relapsed Refractory Multiple Myeloma (DURGA-4)

for Relapsed Refractory Multiple Myeloma

48 locations incl. Gilbert

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07391657·Phase 3·Recruiting

Apply to this trial

Tele-PCIT for Healthy Relationships in Families At-Risk

for Disruptive Behavior

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 2 - 7

Code: NCT07225010·Recruiting

Apply to this trial

Engaging Pharmacists to Advance Tobacco Treatment Service Delivery

for Smoking Cessation

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 21+

Code: NCT07501624·Enrolling By Invitation

A Study to Test Whether Nerandomilast Can Help Slow Down Changes in the Lung in People With a Family History of Pulmonary Fibrosis

for Familial Pulmonary Fibrosis

Drug: Nerandomilast

13 locations incl. Los Angeles

Sponsor: Boehringer Ingelheim

Sex: All·Age: 40+

Code: NCT07201922·Phase 3·Recruiting

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A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated Acute Kidney Injury.

for Sepsis

16 locations incl. Tucson

Sponsor: AstraZeneca

Sex: All·Age: 18 - 80

Code: NCT07215702·Phase 2·Recruiting

Apply to this trial

A Prospective, Post-Market, Clinical Follow-up Study of the Incompass™ Total Ankle System

for Post Traumatic Arthritis

4 locations incl. Morton Grove

Sponsor: Stryker Trauma and Extremities

Sex: All·Age: 21+

Code: NCT07118501·Recruiting

Apply to this trial

A Study to Evaluate the Efficacy, Safety, and Tolerability of VIM0423 in Individuals With Isolated Dystonia

for Dystonia

37 locations incl. Birmingham

Sponsor: Vima Therapeutics

Sex: All·Age: 18 - 65

Code: NCT07304089·Phase 2·Recruiting

Apply to this trial

The REPOSE (Reach for Equity in Pediatric Sleep Evaluation) Navigation Intervention

for Sleep Apnea, Obstructive

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 2 - 12

Code: NCT06828835·Recruiting

Apply to this trial

Brain Metastases in Greater Size - Hypofractionated Options Trial (BIGSHOT)

for Brain Metastases

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07227610·Phase 2·Recruiting

Apply to this trial

GLP1 Fasting Status and Gastric Retention Using Gastric Ultrasound

for Gastric Retention

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07251803·Recruiting

Apply to this trial

Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2

for Gastric Cancer

Drug: Sonesitatug vedotin

77 locations incl. Phoenix

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07431281·Phase 3·Recruiting

Apply to this trial

A Phase 2 Study of LTI-03 in Patients With Idiopathic Pulmonary Fibrosis

for Idiopathic Pulmonary Fibrosis (IPF)

11 locations incl. Birmingham

Sponsor: Rein Therapeutics

Sex: All·Age: 40+

Code: NCT06968845·Phase 2·Recruiting

Apply to this trial

Hypofractionated Radiotherapy With a Focal Microboost for High-Risk and Locally Advanced Prostate Cancer

for Prostate Cancer

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: Male·Age: 18+

Code: NCT07325721·Phase 2·Recruiting

Apply to this trial

Impact of Barostimulation on Hemodynamics in Adults With Heart Failure

for HFrEF - Heart Failure With Reduced Ejection Fraction

7 locations incl. San Francisco

Sponsor: Columbia University

Sex: All·Age: 18+

Code: NCT07335510·Not Yet Recruiting