taVNS + CCT for Neurocognitive Rehab

Part of paid clinical trials in Charleston, South Carolina.

Sponsor
Medical University of South Carolina
Study ID
NCT07517237
Status
Recruiting
Apply to this trial

Conditions

  • Cognitive Complaint
  • Cognitive Dysfunction
  • Neurocognitive Function
  • Psychosocial Well-being

Eligibility Criteria

Sex
ALL
Age
45 Years - 80 Years
Healthy Volunteers
Not accepted

Interventions

  • taVNS — DEVICE
    A Soterix Medical Handheld home-based taVNS device combined with web-based adaptive computerized cognitive training (CCT) will be self-administered for 10, 1 hour treatment sessions at home. CCT will be accessed via the web from a tablet or computer. The premise of a combined approach is that taVNS "primes" brain networks that are then engaged by CCT, synergistically enhancing cognitive benefits.
  • Computerized Cognitive Training — DEVICE
    CCT will be delivered through the online BrainHQ platform. Participants will engage in adaptive visual speed of processing training for approx. 30 minutes per session (10 sessions, total CCT time = 300 min).

Study Details

The purpose of this study is to investigate whether combining transcutaneous auricular vagus nerve stimulation (taVNS) with computerized cognitive training might help improve thinking abilities and mood. Participants will self-administer these treatment in their homes and undergo pre- and post-treatment assessments of thinking abilities and mood and brain MRIs.

Key Dates

Start date
Mar 12, 2026
Status verified
Apr 2026
Primary completion
Sep 15, 2026
Completion
Sep 15, 2026

Study Design

Enrollment
20 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: taVNS + CCT

Primary Outcome Measure

Retention [ Time Frame: From enrollment to the V2 post-treatment assessment (approximately 6 weeks). ]

Locations (1)

FacilityCityStateZIPSite coordinators
Medical University of South CarolinaCharlestonSouth Carolina29425
Averi Jones
[email protected]
843-608-0255

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By research site
Medical University of South Carolina· Charleston, SC

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