Paid Clinical Trials in Boston, MA

As of June 2026, 3,013 paid clinical trials are recruiting in Boston, Massachusetts. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 15, 2026.

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3,009 clinical trials

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A Study of Vemurafenib and Obinutuzumab Compared to Cladribine and Rituximab in People With Hairy Cell Leukemia (HCL)

for Hairy Cell Leukemia

Drug: Rituximab

10 locations incl. Boston

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT06561360·Phase 2·Recruiting

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Long-term Follow-up of Participants Treated With Galapagos Chimeric Antigen Receptor (CAR) T-cell Therapies

for Hematological Malignancies

1 location in Boston

Sponsor: Lakefront Biotherapeutics NV

Sex: All·Age: 18+

Code: NCT06652633·Phase 3·Recruiting

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A Study of Rapcabtagene Autoleucel in Active, Refractory Systemic Lupus Erythematosus (SLE) or Lupus Nephritis (LN) Patients (AUTOGRAPH - SLE/LN)

for Lupus Erythematosus, Systemic

19 locations incl. Birmingham

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 75

Code: NCT06581198·Phase 2·Recruiting

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A Study of TX000045 in Patients With Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection Fraction (the APEX Study)

for Pulmonary Hypertension

31 locations incl. Phoenix

Sponsor: Tectonic Therapeutic

Sex: All·Age: 18 - 83

Code: NCT06616974·Phase 2·Recruiting

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The Coronary Artery Calcium and Troponins in Rheumatoid Arthritis (CAT-RA) Study

for Rheumatoid Arthritis (RA

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 35 - 79

Code: NCT07315997·Recruiting

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Prospective Multicenter Research on Donor and Recipient Management Strategies to Improve Lung Transplant Outcomes

for Lung Transplant

18 locations incl. Los Angeles

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06399302·Recruiting

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PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm

for Coronary Artery Disease

18 locations incl. Chandler

Sponsor: Kardion Inc

Sex: All·Age: 18 - 90

Code: NCT06445608·Recruiting

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Robotic Apparel to Prevent Freezing of Gait in Parkinson Disease

for Parkinson Disease (PD)

2 locations incl. Allston

Sponsor: Harvard Medical School (HMS and HSDM)

Sex: All·Age: 18 - 90

Code: NCT06602544·Recruiting

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Frequency of Selected Single Nucleotide Polymorphisms in Huntington Disease Gene Expansion Carriers

for Huntington Disease

13 locations incl. Birmingham

Sponsor: Hoffmann-La Roche

Sex: All·Age: 25 - 60

Code: NCT06667414·Recruiting

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Cognitive Control to Boost Physical Activity Adherence

for Physical Inactivity

2 locations incl. Iowa City

Sponsor: University of Iowa

Sex: All·Age: 40 - 65·Accepts healthy volunteers

Code: NCT06338774·Recruiting

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The COMPASSION Study

for Breast Cancer

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT06507930·Recruiting

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CRS Questionnaire Validation Project

for Chronic Rhinosinusitis (CRS) With and Without Nasal Polyps

5 locations incl. Santa Monica

Sponsor: The European Forum for Research and Education in Allergy and Airway Diseases

Sex: All·Age: 18+

Code: NCT06970977·Recruiting

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A Multicenter Phase 1b/2 Study of Adagrasib, Cetuximab, and Cemiplimab for Metastatic Colorectal Cancer Harboring KRAS G12C Mutations

for Metastatic Colorectal Cancer

Drug: Cemiplimab

2 locations incl. Boston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06412198·Phase 1, Phase 2·Recruiting

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A Study Comparing Anitocabtagene Autoleucel to Standard of Care Therapy in Participants With Relapsed/ Refractory Multiple Myeloma

for Multiple Myeloma

50 locations incl. Gilbert

Sponsor: Kite, A Gilead Company

Sex: All·Age: 18+

Code: NCT06413498·Phase 3·Recruiting

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Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

for High Grade Glioma

Drug: Ribociclib

11 locations incl. Aurora

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 12 Months - 39

Code: NCT05843253·Phase 2·Recruiting

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Study to Assess Safety and Tolerability of OPN-6602 in Subjects With Relapsed and/or Refractory Multiple Myeloma

for Relapsed Multiple Myeloma

12 locations incl. Gilbert

Sponsor: Opna Bio LLC

Sex: All·Age: 18+

Code: NCT06433947·Phase 1·Recruiting

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Phase 3 Study on the Efficacy and Safety of Human Plasma Derived Antithrombin (Atenativ) in Heparin-Resistant Patients Scheduled to Undergo Cardiac Surgery Necessitating Cardiopulmonary Bypass

for Acquired Antithrombin Deficiency

9 locations incl. Stanford

Sponsor: Octapharma

Sex: All·Age: 18 - 85

Code: NCT06096116·Phase 3·Recruiting

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A Study to Test the Efficacy and Safety of Riliprubart Against the Usual Treatment of Intravenous Immunoglobulin (IVIg) in People With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

for Chronic Inflammatory Demyelinating Polyneuropathy

Drug: riliprubart

29 locations incl. Homewood

Sponsor: Sanofi

Sex: All·Age: 18+

Code: NCT06290141·Phase 3·Recruiting

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Neural Mechanisms of Family-Focused Treatment for Youth Depression

for Childhood Depression

2 locations incl. Boston

Sponsor: Boston University Charles River Campus

Sex: All·Age: 7 - 12·Accepts healthy volunteers

Code: NCT06289010·Recruiting

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PICNIC Study - PatIent Centered aNtIbiotic Courses in Children With Medical Complexity

for Pneumonia

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 2 - 25

Code: NCT06364514·Recruiting

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A Clinical Trial of Combination HIV-Specific Broadly Neutralizing Monoclonal Antibodies Combined With ART Initiation During Acute HIV Infection to Induce HIV Remission

for Acute HIV Infection

32 locations incl. Birmingham

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 70

Code: NCT05719441·Phase 2·Recruiting

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Study of Safety and Efficacy of RGT-61159 in Adults With Relapsed/Refractory Adenoid Cystic Carcinoma (ACC) or Colorectal Carcinoma (CRC)

for Adenoid Cystic Carcinoma

8 locations incl. Boston

Sponsor: Rgenta Therapeutics Inc

Sex: All·Age: 18+

Code: NCT06462183·Phase 1·Recruiting

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Texting to Reduce Human Immunodeficiency Virus (HIV) Risk

for HIV Infections

2 locations incl. Boston

Sponsor: Boston University

Sex: All·Age: 18+

Code: NCT06088277·Recruiting

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Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)

for B-cell Acute Lymphoblastic Leukemia

17 locations incl. Los Angeles

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 6 Months - 25

Code: NCT06395103·Phase 1, Phase 2·Recruiting

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A Prospective Study on the Role of Karl Storz Curved and Straight Fetoscopes (11508AAK and 11506AAK) for Fetoscopic Intrauterine Procedures

for Fetal Conditions

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: Female·Age: 18 - 45

Code: NCT06056635·Recruiting

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A Phase I/II Study of ITU512 in Healthy Participants and Patients With Sickle Cell Disease

for Sickle Cell Disease

5 locations incl. Birmingham

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 12 - 55·Accepts healthy volunteers

Code: NCT06546670·Phase 1, Phase 2·Recruiting

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Safety/Efficacy Study of CID-078 in Patients With Advanced Solid Tumor Malignancies

for Advanced Solid Tumor

10 locations incl. Sarasota

Sponsor: Circle Pharma

Sex: All·Age: 12+

Code: NCT06577987·Phase 1·Recruiting

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A Study Comparing the Efficacy and Safety of Zanidatamab to Trastuzumab, Each in Combination With Physician's Choice Chemotherapy, for the Treatment of Participants With Metastatic HER2-positive Breast Cancer

for Metastatic HER2-positive Breast Cancer

48 locations incl. Phoenix

Sponsor: Jazz Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06435429·Phase 3·Recruiting

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Phase Ib Study of Axatilimab in Combination With Olaparib in BRCA1/2 and PALB2- Associated Metastatic HER2-negative Breast Cancer

for Breast Cancer

3 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT06488378·Phase 1·Recruiting

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Best Practice Advisories to Reduce Inequities in Technology Use for People With Type 1 Diabetes

for Diabetes Mellitus, Type 1

2 locations incl. Boston

Sponsor: T1D Exchange, United States

Sex: All·Age: 2 - 95·Accepts healthy volunteers

Code: NCT06931275·Recruiting

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Phase 3 Study of T-DXd and Rilvegostomig Versus SoC in Advanced HER2-expressing Biliary Tract Cancer

for Biliary Tract Cancer

Drug: Rilvegostomig

48 locations incl. Scottsdale

Sponsor: AstraZeneca

Sex: All·Age: 18 - 99

Code: NCT06467357·Phase 3·Recruiting

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Crohn's Disease: Efficacy, Safety, and Pharmacokinetics of Upadacitinib in Pediatric Subjects With Moderately to Severely Active Crohn's Disease

for Crohn's Disease

Drug: Upadacitinib

12 locations incl. Oakland

Sponsor: AbbVie

Sex: All·Age: 2 - 17

Code: NCT06332534·Phase 3·Recruiting

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The SAPPHO Study: Sequential Therapy With Curative Intent in de Novo HER2+ Metastatic Breast Cancer

for Breast Cancer Female

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT06439693·Phase 2·Recruiting

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Autologous iPSC-Derived Dopamine Neuron Transplantation for Parkinson's Disease

for Parkinson Disease

1 location in Boston

Sponsor: Penelope J. Hallett, Ph.D.

Sex: All·Age: 55 - 80

Code: NCT06422208·Phase 1·Enrolling By Invitation

Neurofibromatosis Type 1 Tumor Early Detection Study

for Neurofibromatosis Type 1

1 location in Boston

Sponsor: David Miller

Sex: All·Age: 18+

Code: NCT06515860·Recruiting

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Characterization And Clinical Outcomes of AA Patients Treated With Ritlecitinib

for Alopecia Areata

Drug: Ritlecitinib

25 locations incl. Montgomery

Sponsor: Pfizer

Sex: All·Age: 12+

Code: NCT06531109·Recruiting

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A Study of Surovatamig (AZD0486) Plus Rituximab in Previously Untreated Follicular Lymphoma Patients

for Untreated Follicular Lymphoma

Drug: Rituximab

51 locations incl. Huntsville

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06549595·Phase 3·Recruiting

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Mobile Application to Improve Health-Related Outcomes in Patients With Advanced Lung Cancer

for Lung Cancer

3 locations incl. Los Angeles

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06427954·Recruiting

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Developing Restful Environments and Management Strategies for Pediatric Stem Cell Transplant Patients

for Stem Cell Transplant Complications

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 9 - 17

Code: NCT06468618·Recruiting

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A Study to Learn if 27T51, a Mucin-16 (MUC16) Protein Targeting Immune Cell Therapy, Administered Alone or in Combination is Safe and How Well it Works for Adult Participants With Recurrent or Treatment Resistant Ovarian Cancers

for Epithelial Ovarian Cancer

5 locations incl. Boston

Sponsor: Regeneron Pharmaceuticals

Sex: Female·Age: 18+

Code: NCT06469281·Phase 1·Recruiting

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