Clinical Trials at Massachusetts General Hospital

As of June 2026, 726 paid clinical trials are recruiting at Massachusetts General Hospital, located at Faustman Lab at Massachusetts General Hospital, 149 13th St #3602, Boston, MA 02129, phone (617) 726-4084 in Boston, Massachusetts. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

Filter results

Filter results

State

City

Facility

Phase

Study type

Intervention

Recruitment status

Condition

Sex

Age

Healthy volunteers only

726 clinical trials at Massachusetts General Hospital

·Clear filters·↓ Download CSV

Using 18F-FAPI PET to Detect Metastatic Disease in Patients That Have Pancreatic Ductal Adenocarcinoma (PDAC)

for Pancreatic Ductal Adenocarcinoma (PDAC)

14 locations incl. Cerritos

Sponsor: SOFIE

Sex: All·Age: 18+

Code: NCT07217717·Phase 3·Recruiting

Apply to this trial

Kisspeptin Administration Subcutaneously to Patients With Hypothalamic Amenorrhea

for Hypothalamic Amenorrhea

1 location in Boston

Sponsor: Stephanie B. Seminara, MD

Sex: Female·Age: 18 - 45

Code: NCT07224438·Phase 2·Recruiting

Apply to this trial

Safety and Tolerability Study of ST-503 for Refractory Pain Due to Peripheral Neuropathy (Small Fiber Predominant, SFN)

for Chronic Neuropathic Pain

11 locations incl. Scottsdale

Sponsor: Sangamo Therapeutics

Sex: All·Age: 18+

Code: NCT06980948·Phase 1, Phase 2·Recruiting

Apply to this trial

Enhancing Recovery Capital Amid Opioid Use Disorder Pharmacotherapy: A Pilot Randomized Trial

for Opioid Use Disorder

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05245513·Not Yet Recruiting

A Phase Ⅰ/Ⅱa Study of SNUG01 in Adult Subjects With ALS

for Amyotrophic Lateral Sclerosis (ALS)

1 location in Boston

Sponsor: SineuGene Therapeutics Co., Ltd.

Sex: All·Age: 18 - 80

Code: NCT07169175·Phase 1, Phase 2·Not Yet Recruiting

Safety Study of XT-150 in Participants With ALS

for Amyotrophic Lateral Sclerosis (ALS)

4 locations incl. Phoenix

Sponsor: Xalud Therapeutics, Inc.

Sex: All·Age: 18 - 80

Code: NCT06704347·Phase 1·Not Yet Recruiting

Strategic Help With Immunoglobulin to Enhance Protect Against Late Disease (CMV)

for Cytomegalovirus

2 locations incl. Boston

Sponsor: Camille N. Kotton, MD

Sex: All·Age: 18 - 75

Code: NCT06958796·Phase 4·Recruiting

Apply to this trial

A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease

for Parkinson's Disease

Drug: Prasinezumab

42 locations incl. Birmingham

Sponsor: Hoffmann-La Roche

Sex: All·Age: 50 - 85

Code: NCT07174310·Phase 3·Recruiting

Apply to this trial

Impact of Pectoral Versus Paravertebral Blocks on Pain and Physical Well-Being in Implant-Based Breast Reconstruction

for Breast Reconstruction

1 location in Boston

Sponsor: Amy Colwell

Sex: All·Age: 18+

Code: NCT07209436·Recruiting

Apply to this trial

Effect of Intravenous and Topical Tranexamic Acid on Drain Output in Breast Reduction Surgery

for Drain Output After Breast Reduction Surgery

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18+

Code: NCT07131592·Phase 4·Recruiting

Apply to this trial

Using 18F-FAPI PET to Detect Metastatic Disease in Patients That Have Gastric or Esophageal Cancer.

for Esophageal Cancer

14 locations incl. Cerritos

Sponsor: SOFIE

Sex: All·Age: 18+

Code: NCT07217704·Phase 3·Recruiting

Apply to this trial

A Study of INCB123667 in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression

for Ovarian Cancer

Drug: INCB123667

42 locations incl. Mobile

Sponsor: Incyte Corporation

Sex: Female·Age: 18 - 99

Code: NCT07023627·Phase 2·Recruiting

Apply to this trial

A Virtual Reality Vaping Prevention Intervention for Adolescents

for Vaping

2 locations incl. New Haven

Sponsor: Yale University

Sex: All·Age: 12 - 15·Accepts healthy volunteers

Code: NCT07362069·Enrolling By Invitation

A Study of Dupilumab in Small Children With an Allergic Condition of the Esophagus (Food Pipe): Eosinophilic Esophagitis

for Eosinophilic Esophagitis (EoE)

Drug: Dupilumab

10 locations incl. Phoenix

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 6 Months - 6

Code: NCT07112378·Phase 3·Recruiting

Apply to this trial

A Global Study Comparing Pulsed Field Ablation With Electrographic Flow Mapping Versus Posterior Wall Ablation for Persistent Atrial Fibrillation

for Atrial Fibrillation (AF)

32 locations incl. Birmingham

Sponsor: Boston Scientific Corporation

Sex: All·Age: 18+

Code: NCT07187115·Recruiting

Apply to this trial

Effect of Tirzepatide and Bimagrumab on Body Composition, Insulin Sensitivity, and Bone in Adults With Obesity

for Obesity

Drug: Tirzepatide

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05933499·Phase 2·Recruiting

Apply to this trial

Behavioral Health Program for Short-Stay Nursing Facility Residents & Care Partners

for Nursing Home Resident

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07220486·Recruiting

Apply to this trial

The PREGNANT (Pregnant Resident Empowerment, GuidaNce, and Advocacy iN Training) Coaching Project

for Burnout, Professional

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT07221422·Recruiting

Apply to this trial

CCM OPEN HF Registry

for Heart Failure

28 locations incl. Mesa

Sponsor: Impulse Dynamics

Sex: All·Age: 18+

Code: NCT07112924·Recruiting

Apply to this trial

Well-being in IBS: Strengths and Happiness (WISH) 2.0

for Irritable Bowel Syndrome

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06866106·Recruiting

Apply to this trial

Synergistic Gut-brain Axis Modulation Via Vagal Stimulation and Support Therapy in Functional Dyspepsia

for Functional Dyspepsia

1 location in Boston

Sponsor: Spaulding Rehabilitation Hospital

Sex: All·Age: 18 - 65

Code: NCT06360900·Recruiting

Apply to this trial

A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer

for Non-Small Cell Lung Cancer

Drug: Divarasib

50 locations incl. Anchorage

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT06793215·Phase 3·Recruiting

Apply to this trial

Care in Multiple Sclerosis (MS)

for Multiple Sclerosis

6 locations incl. Birmingham

Sponsor: NYU Langone Health

Sex: All·Age: 18+

Code: NCT07011914·Recruiting

Apply to this trial

A Study of LY4337713 in Participants With FAP-Positive Solid Tumors

for Ovarian Neoplasms

20 locations incl. Newport Beach

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07213791·Phase 1·Recruiting

Apply to this trial

Mind-body Resilience Program for Cardiac Arrest Survivors and Their Caregivers: Recovering Together After Cardiac Arrest

for Emotional Distress

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07143357·Recruiting

Apply to this trial

Phase I Study of [225Ac]Ac-ETN029 in Patients With Advanced DLL3-expressing Solid Tumors

for Small Cell Lung Carcinoma

4 locations incl. Iowa City

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 100

Code: NCT07006727·Phase 1·Recruiting

Apply to this trial

A Study of ASP2138 Given Before Surgery, Then Chemotherapy After Surgery, in People With Pancreatic Ductal Cancer

for Pancreatic Ductal Adenocarcinoma

3 locations incl. Boston

Sponsor: Astellas Pharma Global Development, Inc.

Sex: All·Age: 18+

Code: NCT07024615·Phase 1·Recruiting

Apply to this trial

Spironolactone to Improve Pregnancy-Associated Hypertension Trajectories

for Preeclampsia

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18+

Code: NCT07041281·Phase 2·Recruiting

Apply to this trial

Identifying and Addressing Barriers to Retention in the Cervical Cancer Treatment Cascade Among Women With HIV in South Africa: Part 2

for Cervical Cancer

2 locations incl. Boston

Sponsor: Boston University Charles River Campus

Sex: Female·Age: 18+

Code: NCT06182241·Not Yet Recruiting

Cognitive Rehabilitation for Refugees With Traumatic Brain Injury and Cognitive Impairment

for TBI (Traumatic Brain Injury)

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT06839079·Recruiting

Apply to this trial

Impact of Disclosing Coronary Artery Disease Polygenic Risk Score on Cardiovascular Health

for Coronary Artery Disease

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 30 - 75

Code: NCT07087431·Recruiting

Apply to this trial

Impact of Earplugs on Mechanisms of Noise-Related Cardiovascular Disease

for Cardiometabolic Diseases

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT07148817·Recruiting

Apply to this trial

Pain Disengagement Training (Open Pilot)

for Chronic Musculoskeletal Pain

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06870162·Recruiting

Apply to this trial

Precision Biomarkers to Detect Brain Injury in Active-Duty United States Special Operations Forces With Repeated Blast Exposure

for Blast Injury

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Male·Age: 18 - 50

Code: NCT07131475·Phase 2·Recruiting

Apply to this trial

Subcortical Arousal in Perceptual Awareness

for Epilepsy

8 locations incl. New Haven

Sponsor: Yale University

Sex: All·Age: 13+

Code: NCT06934356·Recruiting

Apply to this trial

Ivonescimab in Comb. With FOLFOX in Advanced HER2 Neg. GEA

for Stomach Cancer Stage IV

Drug: Ivonescimab

2 locations incl. Santa Monica

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07070466·Phase 2·Recruiting

Apply to this trial

PDAC-PATHWAYS: A Digital Informational and Supportive Care App for Patients Initiating Neoadjuvant Therapy for Pancreatic Ductal Adenocarcinoma

for PDAC - Pancreatic Ductal Adenocarcinoma

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07047807·Recruiting

Apply to this trial

Personalized Risk Estimation for Crohn's Disease (PRE-Crohn's): Implementation and Feasibility

for Inflammatory Bowel Diseases

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 14+·Accepts healthy volunteers

Code: NCT05332639·Recruiting

Apply to this trial

CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) Amyloidosis

for Transthyretin Amyloid Cardiomyopathy (ATTR CM)

Drug: Coramitug

61 locations incl. Phoenix

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07207811·Phase 3·Recruiting

Apply to this trial

Targeted Palliative Care Intervention for Patients With Metastatic Breast Cancer

for Metastatic Breast Cancer

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06795529·Recruiting

Apply to this trial