Clinical Trials at Massachusetts General Hospital

As of June 2026, 726 paid clinical trials are recruiting at Massachusetts General Hospital, located at Faustman Lab at Massachusetts General Hospital, 149 13th St #3602, Boston, MA 02129, phone (617) 726-4084 in Boston, Massachusetts. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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726 clinical trials at Massachusetts General Hospital

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A First-in-human Study of RLY-8161 in Advanced NRAS-Mutant Solid Tumors

for Advanced NRAS-Mutant Melanoma

6 locations incl. Los Angeles

Sponsor: Relay Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07584226·Phase 1·Recruiting

Apply to this trial

Ketamine add-on Therapy for Established Status Epilepticus Treatment Trial (KESETT)

for Status Epilepticus

52 locations incl. Tucson

Sponsor: University of Virginia

Sex: All·Age: 1+

Code: NCT06907173·Phase 3·Recruiting

Apply to this trial

A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer

for CRC (Colorectal Cancer)

Drug: Bevacizumab

80 locations incl. Chandler

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT07284849·Phase 3·Recruiting

Apply to this trial

Pilot Study of a Brain Health Program in Senior Centers

for Memory Loss (Excluding Dementia)

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 50+

Code: NCT07424443·Recruiting

Apply to this trial

Effects of Estrogen on Heart Health in Women With Primary Ovarian Insufficiency

for Primary Ovarian Insufficiency

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 30 - 40·Accepts healthy volunteers

Code: NCT06866119·Not Yet Recruiting

Finding Links Between Hot flASHes and CardioVascular Disease

for Menopause-related Hot Flashes

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 40 - 65

Code: NCT07077395·Phase 2·Recruiting

Apply to this trial

Plasma and Radiologic Biomarkers of Response to ECP in Lung Transplant Recipients With CLAD

for Lung Transplant Failure and Rejection

3 locations incl. Boston

Sponsor: Brian Keller

Sex: All·Age: 7+

Code: NCT07434869·Not Yet Recruiting

KHENERFIN Study: A Trial to Evaluate the Efficacy and Safety of Sonlicromanol in Primary Mitochondrial Diseases

for Mitochondrial Diseases

3 locations incl. Boston

Sponsor: Khondrion BV

Sex: All·Age: 18+

Code: NCT06451757·Phase 3·Recruiting

Apply to this trial

LiverSleep: A Behavioral Sleep Intervention for Patients With Cirrhosis and Insomnia

for Cirrhosis

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07417163·Recruiting

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Long-acting Cabotegravir Injectable Pre-exposure Prophylaxis for People Who Inject Drugs

for HIV

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07199335·Phase 4·Recruiting

Apply to this trial

Preliminary Efficacy Trial of a Digital Intervention for Depression and Cannabis Use

for Depression - Major Depressive Disorder

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06878859·Recruiting

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iNO300 Therapy in Critically Ill Patients With Pneumonia

for Critical Illness

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06950294·EARLY_Phase 1·Recruiting

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Momelotinib During and After HCT in Myelofibrosis

for Myelofibrosis

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07104799·Phase 1·Recruiting

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Investigating Subcortical Contributions to Speech Sequencing in Deep Brain Stimulator Recipients

for Parkinson's Disease (PD)

2 locations incl. Boston

Sponsor: Boston University Charles River Campus

Sex: All·Age: 18+

Code: NCT07455760·Recruiting

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A Prospective Longitudinal Observational Cohort Study of Pregnant Women Residing at High Altitude in Bolivia

for Hypertensive Disorder of Pregnancy

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18 - 45·Accepts healthy volunteers

Code: NCT07312227·Recruiting

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A Study of JNJ-79635322 in Participants With Relapsed or Refractory Multiple Myeloma

for Multiple Myeloma

29 locations incl. Birmingham

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT07266441·Phase 2·Recruiting

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A Digital Health Intervention to Improve Physical Function and Wellness of Lung Cancer Survivors

for Advanced Lung Cancer

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07227623·Recruiting

Apply to this trial

Voice Therapy Per the Rehabilitation Treatment Specification System

for Muscle Tension Dysphonia

5 locations incl. Atlanta

Sponsor: Massachusetts General Hospital

Sex: All·Age: 14+

Code: NCT06152627·Recruiting

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The TEAM Study - Treatment Efficacy for Autism/Attention Using Mixed Amphetamine

for Attention Deficit Hyperactivity Disorder (ADHD)

1 location in Boston

Sponsor: Gagan Joshi

Sex: All·Age: 8 - 18·Accepts healthy volunteers

Code: NCT06853665·Phase 4·Recruiting

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The Impact of Dry Needling on Electrophysiological and Ultrasound-based Biomarkers for Myofascial Pain

for Trigger Point in Trapezius Muscle

2 locations incl. Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18 - 80

Code: NCT07270276·Recruiting

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Enhancing Heart Allograft Function With the OCS Heart System Trial

for Heart Transplant

8 locations incl. San Francisco

Sponsor: TransMedics

Sex: All·Age: 18+

Code: NCT07145515·Recruiting

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Study to Evaluate the Safety and Efficacy of Larsucosterol in Participants With Alcohol-associated Hepatitis (AH)

for Hepatitis

Drug: Larsucosterol

48 locations incl. Birmingham

Sponsor: Bausch Health Americas, Inc.

Sex: All·Age: 18+

Code: NCT07428538·Phase 3·Recruiting

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Immune Response to Percutaneous Hepatic Perfusion With Melphalan for Ocular Melanoma Metastatic to the Liver

for Uveal Melanoma

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07364474·Recruiting

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Neoadjuvant Darovasertib in Primary Uveal Melanoma

for Uveal Melanoma

35 locations incl. Scottsdale

Sponsor: IDEAYA Biosciences

Sex: All·Age: 18+

Code: NCT07015190·Phase 3·Recruiting

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A One-Arm Open Trial of a Smartphone Delivered Treatment for Suicidal Thoughts and Behavior

for Suicide Attempt

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06967545·Recruiting

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Ivosidenib as Post-HSCT Maintenance for AML

for IDH1 Mutation

4 locations incl. Atlanta

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 75

Code: NCT06707493·Phase 2·Recruiting

Apply to this trial

Primary Care Pragmatic, Real World Experience for Automated Insulin Delivery

for Type 1 Diabetes (T1D)

2 locations incl. Aurora

Sponsor: University of Colorado, Denver

Sex: All·Age: 18 - 89

Code: NCT07011147·Recruiting

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Horizon 360 Protocol for the Treatment of Paroxysmal Atrial Fibrillation With the Sphere-360™ Catheter and Affera™ Mapping and Ablation System (Horizon 360)

for Paroxysmal AF

15 locations incl. Jonesboro

Sponsor: Medtronic Cardiac Ablation Solutions

Sex: All·Age: 18 - 80

Code: NCT07308847·Recruiting

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First-in-human Study of 7MW4911 in GI Cancer

for GI Cancers

5 locations incl. Port Saint Lucie

Sponsor: Mabwell (Shanghai) Bioscience Co., Ltd.

Sex: All·Age: 18+

Code: NCT07216560·Phase 1, Phase 2·Recruiting

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Feasibility and Acceptability of Primary Palliative Care Intervention in Patients Undergoing Hematopoietic Stem Cell Transplantation

for Hematopoietic Cell Transplant

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06676852·Recruiting

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Multi-site Trial of a Brief Behavioral Intervention for Dyspnea in Patients With Advanced Lung Cancer

for Advanced Lung Cancer

3 locations incl. Coral Gables

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06791057·Not Yet Recruiting

Study to Assess Safety, Efficacy and Persistence of ACE1831, in Subjects With IgG4-Related Disease

for IgG4 Related Disease

2 locations incl. Atlanta

Sponsor: Acepodia Biotech, Inc.

Sex: All·Age: 18 - 75

Code: NCT07061938·Phase 1, Phase 2·Recruiting

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Screening Cardiometabolic Opportunities Using Transformative Echocardiography Artificial Intelligence (SCOUT Echo-AI)

for MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease

4 locations incl. Los Angeles

Sponsor: Kaiser Permanente

Sex: All·Age: 18+

Code: NCT07216859·Not Yet Recruiting

Post-Market Study of the Signia Circular Stapler With Tri-Staple Technology in Left-sided Colon, Sigmoid, and Rectal Resections

for Colorectal Anastomosis

8 locations incl. New Haven

Sponsor: Medtronic - MITG

Sex: All·Age: 18+

Code: NCT07351071·Recruiting

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Tailoring an Online Platform to Promote Evidence-Based Care for Adults With Neurofibromatosis 1 and Low Health Literacy

for Neurofibromatosis 1

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07233408·Recruiting

Apply to this trial

Diagnosing Epilepsy To EffeCT Change

for Epilepsy

18 locations incl. Phoenix

Sponsor: Epiminder America, Inc.

Sex: All·Age: 18 - 75

Code: NCT07110337·Recruiting

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Mezigdomide and Talquetamab in Relapsed and Refractory Multiple Myeloma

for Relapsed Refractory Multiple Myeloma (RRMM)

Drug: Mezigdomide

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07032714·Phase 1·Recruiting

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A Study to Evaluate the Safety and Effectiveness of the Rapidlink Device When Used in Patients Undergoing an Open Surgical Procedure to Repair the Aorta

for Aortic Aneurysm

16 locations incl. Los Angeles

Sponsor: Vascutek Ltd.

Sex: All·Age: 18+

Code: NCT07078383·Recruiting

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Study of NXP900 With Osimertinib in Subjects With Advanced, EGFR-Mutated Non-Small Cell Lung Cancer

for EGFR Mutation Positive Non-small Cell Lung Cancer

Drug: Osimertinib

3 locations incl. Boston

Sponsor: Nuvectis Pharma, Inc.

Sex: All·Age: 18+

Code: NCT07315113·Phase 1·Recruiting

Apply to this trial

A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract

for Carcinoma, Transitional Cell

60 locations incl. Huntsville

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07218380·Phase 3·Recruiting

Apply to this trial