A Prospective Longitudinal Observational Cohort Study of Pregnant Women Residing at High Altitude in Bolivia

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Massachusetts General Hospital
Study ID
NCT07312227
Status
Recruiting
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Conditions

  • Hypertensive Disorder of Pregnancy
  • Intrauterine Growth Restriction
  • Pulmonary Arterial Hypertension

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 45 Years
Healthy Volunteers
Accepted

Study Details

In this study, the investigators will follow two small cohorts of pregnant women: a cohort of healthy women with uncomplicated pregnancies residing at high altitude, a control group of healthy women with uncomplicated pregnancies residing at sea level, to characterize differences in cardiopulmonary adaptation and nitric oxide (NO) pathway expression at elevations \>3,500 m throughout pregnancy and into the postpartum period. The investigators aim to investigate right-sided cardiac impairment induced by chronic hypobaric hypoxemia, its effects on fetal growth, and the potential contribution of cardiovascular nitric oxide depletion to obstetric complications.

Key Dates

Start date
Feb 11, 2026
Status verified
May 2026
Primary completion
Dec 31, 2026
Completion
Feb 28, 2027

Study Design

Enrollment
27 participants (estimated)

Arms

  • Arm: Healthy pregnant women residing at high altitude
    Women with uncomplicated pregnancy.
  • Arm: Healthy pregnant women residing at sea level
    Women with uncomplicated pregnancy.

Primary Outcome Measure

Pulmonary artery pressures [ Time Frame: Late pregnancy (35 ± 4 weeks gestation) and postpartum (6 ± 0.3 weeks) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Massachusetts General HospitalBostonMassachusetts02114
Lorenzo Berra, MD

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By research site
Massachusetts General Hospital· Boston, MA

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