Preliminary Efficacy Trial of a Digital Intervention for Depression and Cannabis Use

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Massachusetts General Hospital
Study ID
NCT06878859
Status
Recruiting
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Conditions

  • Cannabis Use Disorder
  • Depression - Major Depressive Disorder
  • Mental Disorder

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Amplification of Positivity - Cannabis Use (AMP-C) — BEHAVIORAL
    AMP-C is a smartphone-based digital intervention that includes activities that focus on positivity (e.g., noticing and capitalizing on positive events) to increase positive emotions, thoughts, and behaviors. The role and impact of CU on the maintenance of depression and reward dysfunction (and vice versa), is intertwined throughout the intervention.

Study Details

The purpose of this study is to examine the feasibility, acceptability, and preliminary efficacy of a digital intervention for co-occurring cannabis use and depression. Participants will be randomized to complete Amplification of Positivity - Cannabis Use (AMP-C) or symptom tracking. The main outcomes will include changes in depressive symptoms and cannabis use, as well as usability ratings.

Key Dates

Start date
Feb 23, 2026
Status verified
May 2026
Primary completion
Jan 31, 2028
Completion
Jun 29, 2029

Study Design

Enrollment
80 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Amplification of Positivity - Cannabis Use (AMP-C)
  • No Intervention: Symptom Tracking

Primary Outcome Measure

Change in Depressive Symptoms (Patient Health Questionnaire-9; PHQ-9) [ Time Frame: Baseline, Primary Endpoint: Post-Intervention (approximately one week after completing intervention), Secondary Endpoints: Intervention Midpoint (4 weeks into intervention), 1-, 3-, 6-, and 12-months after completing intervention ]

Locations (1)

FacilityCityStateZIPSite coordinators
Massachusetts General HospitalBostonMassachusetts02114
Shirley Wu, BS
[email protected]
617-724-3532
Amanda C Collins, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
Massachusetts General Hospital· Boston, MA

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