Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness

Part of paid clinical trials in Sunnyvale, California.

Sponsor
Brigham and Women's Hospital
Study ID
NCT06376734
Phase
PHASE2
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • Transcranial magnetic stimulation — DEVICE
    Accelerated TMS will be provided for 2 days using the same dosing regimen as the FDA-cleared SAINT protocol, ten 9-minute treatments per day.

Study Details

Participants will receive Transcranial Magnetic Stimulation (TMS) at a random location in the left prefrontal cortex, excluding sites that are potentially unsafe. Extensive behavioral testing will be conducted to determine which behaviors are modulated by stimulating which circuits.

Key Dates

Start date
Jan 30, 2025
Status verified
Feb 2026
Primary completion
Jun 1, 2029
Completion
Jun 1, 2030

Study Design

Enrollment
180 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: TMS to random PFC location 1
    Participants will receive 2 days of accelerated TMS (10 treatments per day) to a random location in the prefrontal cortex.
  • Experimental: TMS to random PFC location 2
    After a 2-month washout following arm 1, participants will receive another two days of accelerated iTBS treatment at a different random PFC location.
  • Experimental: TMS to Schizophrenia location
    Patients with schizophrenia will be offered to participate in a third arm of the trial, during which participants will receive 2 days of accelerated iTBS to a schizophrenia-specific target.

Primary Outcome Measure

Clustering of multiple behavioral measures [ Time Frame: through study completion, average of 3 months ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Acacia ClinicsSunnyvaleCalifornia94087
Danielle DeSouza, PhD
[email protected]
857-307-0294
Danielle DeSouza, MD (SUB_INVESTIGATOR)
Brigham and Women's HospitalBostonMassachusetts02115
Emily Aquadro, MD
[email protected]
857-307-0294
Shan Siddiqi, MD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Sunnyvale, CA

By condition
DepressionSchizophrenia
By specialty
PsychiatryMental healthBehavioral health
By research site
Acacia Clinics· Sunnyvale, CABrigham and Women's Hospital· Boston, MA

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