Efficacy of Nitrous Oxide in OCD: Pilot Study

Part of paid clinical trials in Stanford, California.

Sponsor
Stanford University
Study ID
NCT03826693
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

  • Obsessive-Compulsive Disorder

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • Nitrous Oxide — DRUG
    OCD participants in this arm will receive 50%oxygen/50% nitrous oxide admixture for 60 minutes.
  • Nitrogen — DRUG
    OCD participants in this arm will receive 50%oxygen/50% nitrogen admixture for 60 minutes.

Study Details

This study investigates whether the commonly used and well-tolerated inhaled anesthetic nitrous oxide can rapidly improve symptoms of OCD.

Key Dates

Start date
Apr 17, 2021
Status verified
Aug 2025
Primary completion
Sep 30, 2026
Completion
Oct 31, 2027

Study Design

Enrollment
45 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Experimental: Nitrous Oxide
    OCD participants in this arm will receive 50%oxygen/50% nitrous oxide admixture for 60 minutes.
  • Placebo Comparator: Control: Nitrogen
    OCD participants in this arm will receive 50%oxygen/50% nitrogen admixture for 60 minutes.

Primary Outcome Measure

Improvement in the severity of OCD symptoms as measured by the Yale-Brown Obsessive Compulsive Scale (YBOCS) [ Time Frame: 1 week ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Stanford UniversityStanfordCalifornia94304
Pavithra Makunda, MS
[email protected]
650-723-4095
Sindu Menon, MBBS
[email protected]
650-723-4095
Peter van Roessel, MD, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Stanford, CA

By research site
Stanford University· Stanford, CA

Related Studies