Clinical Trials at Massachusetts General Hospital

As of June 2026, 726 paid clinical trials are recruiting at Massachusetts General Hospital, located at Faustman Lab at Massachusetts General Hospital, 149 13th St #3602, Boston, MA 02129, phone (617) 726-4084 in Boston, Massachusetts. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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726 clinical trials at Massachusetts General Hospital

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Precision Diagnostics in Inflammatory Bowel Disease, Cellular Therapy and Transplantation (The PREDICT Trial)

for Graft Vs Host Disease

4 locations incl. Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: All ages

Code: NCT03369353·Enrolling By Invitation

A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements

for Locally Advanced Solid Tumors

Drug: Repotrectinib

49 locations incl. Duarte

Sponsor: Turning Point Therapeutics, Inc.

Sex: All·Age: 12+

Code: NCT03093116·Phase 1, Phase 2·Recruiting

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INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT)

for Glioblastoma

12 locations incl. Birmingham

Sponsor: Patrick Wen, MD

Sex: All·Age: 18+

Code: NCT02977780·Phase 2·Recruiting

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Palbociclib and Pembrolizumab In Central Nervous System Metastases

for Metastatic Malignant Neoplasm to Brain

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT02896335·Phase 2·Recruiting

Apply to this trial

Partners Calciphylaxis Biobank

for Calciphylaxis

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT03032835·Recruiting

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Primary Tumor Research and Outcomes Network

for Spinal Column Tumor

9 locations incl. Los Angeles

Sponsor: AO Innovation Translation Center

Sex: All·Age: All ages

Code: NCT02790983·Recruiting

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Feasibility of the LUM Imaging System for Detection of Gastrointestinal Cancers

for Colorectal Cancer

1 location in Boston

Sponsor: Lumicell, Inc.

Sex: All·Age: 18+

Code: NCT02584244·Phase 1, Phase 2·Recruiting

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COMPASSION S3 - Evaluation of the SAPIEN 3 Transcatheter Heart Valve in Patients With Pulmonary Valve Dysfunction

for Complex Congenital Heart Defect

25 locations incl. Little Rock

Sponsor: Edwards Lifesciences

Sex: All·Age: All ages

Code: NCT02744677·Recruiting

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Caloric Restriction In Sarcoma Patients Treated With Pre-Operative RT

for Tumor Surgery

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT02792270·Recruiting

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Montalcino Aortic Consortium: Precision Medicine for Heritable Thoracic Aortic Disease

for Aortic Aneurysm

14 locations incl. Newport Beach

Sponsor: The University of Texas Health Science Center, Houston

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT04005976·Recruiting

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Quality of Pediatric Resuscitation in a Multicenter Collaborative

for Cardiac Arrest

40 locations incl. Los Angeles

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 0 - 18

Code: NCT02708134·Recruiting

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Pilot Study for TCE Imaging of the Esophagus Using an OFDI Capsule With a Compact Imaging System

for Barrett's Esophagus

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 14 - 85·Accepts healthy volunteers

Code: NCT02947971·Recruiting

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Biomechanical Precision Medicine Registry for Patients With and Without Heart Failure

for Heart Failure With Normal Ejection Fraction

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT03480633·Recruiting

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Positron Emission Tomography (PET) Imaging of Thrombosis

for Atrial Fibrillation

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT03830320·Phase 1·Recruiting

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Multi-center Evaluation of the Clinical Utility of ESD in the Western Population

for Endoscopic Submucosal Dissection

3 locations incl. Gainesville

Sponsor: University of Florida

Sex: All·Age: 18 - 100

Code: NCT02989818·Recruiting

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Optical Imaging of Gastrointestinal Biopsy Samples and Their Correlation With Histology

for Gastrointestinal Disease

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04565704·Enrolling By Invitation

Functional GI Disease Registry

for Functional Gastrointestinal Disorders

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05295446·Enrolling By Invitation

TSC Biosample Repository and Natural History Database

for Tuberous Sclerosis

24 locations incl. Birmingham

Sponsor: National Tuberous Sclerosis Association

Sex: All·Age: All ages

Code: NCT05676099·Recruiting

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CAR-T Long Term Follow Up (LTFU) Study

for Long Term Safety of Patients Receiving CAR-T in an Eligible Clinical Trial or Managed Access Program

44 locations incl. Phoenix

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 0 - 100

Code: NCT02445222·Phase 3·Recruiting

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Clinical and Genetic Evaluation of Individuals With Undiagnosed Disorders Through the Undiagnosed Diseases Network

for Genetic Disease

33 locations incl. Birmingham

Sponsor: National Human Genome Research Institute (NHGRI)

Sex: All·Age: 1 Month - 100·Accepts healthy volunteers

Code: NCT02450851·Recruiting

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A Phase II Evaluation of Afatinib in Patients With Persistent or Recurrent HER2-positive Uterine Serous Carcinoma

for HER2/Neu+ Uterine Serous Carcinoma

3 locations incl. Tucson

Sponsor: Yale University

Sex: Female·Age: 18 - 100

Code: NCT02491099·Phase 2·Recruiting

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Chemotherapy-induced Cognitive and Brain Changes in Older Adults With Breast Cancer

for Impaired Cognition

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 60+·Accepts healthy volunteers

Code: NCT02290834·Recruiting

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Biomarker Development for Muscular Dystrophies

for Myotonic Dystrophy

5 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 5+·Accepts healthy volunteers

Code: NCT05019625·Recruiting

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Bronchial NIR Image-guided Resection

for Sentinel Lymph Node

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT03097575·Phase 1, Phase 2·Recruiting

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Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations

for Traumatic Brain Injury

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT04296604·Recruiting

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Phase II Study of Proton Radiation Therapy for Neuroblastoma

for Neuroblastoma

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 6 Months - 25

Code: NCT02112617·Recruiting

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Study of the Kono-S Anastomosis Versus the Side-to-side Functional End Anastomosis

for Crohn's Disease

6 locations incl. Boston

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18 - 90

Code: NCT03256240·Recruiting

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Registry of Deep Brain Stimulation With the VERCISE™ System: Vercise DBS Registry

for Parkinson's Disease

28 locations incl. Aliso Viejo

Sponsor: Boston Scientific Corporation

Sex: All·Age: 18+

Code: NCT02071134·Recruiting

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Study of Orally Administered AG-120 in Subjects With Advanced Hematologic Malignancies With an IDH1 Mutation

for Relapsed or Refractory Acute Myeloid Leukemia (AML)

26 locations incl. Birmingham

Sponsor: Institut de Recherches Internationales Servier

Sex: All·Age: 18+

Code: NCT02074839·Phase 1·Recruiting

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Imaging the Duodenum Using an Optical Frequency Domain Imaging OFDI Capsule

for Celiac Disease

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 16+·Accepts healthy volunteers

Code: NCT02202681·Enrolling By Invitation

A Study to Test the Diagnostic Potential of Brillouin Microscopy for Corneal Ectasia

for Keratoconus

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 20 - 75·Accepts healthy volunteers

Code: NCT02118922·Recruiting

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Proton or Photon RT for Retroperitoneal Sarcomas

for Retroperitoneal Sarcoma

10 locations incl. Chicago

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT01659203·Phase 1, Phase 2·Recruiting

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Proton and Photon Consortium Registry (PPCR): A Multi Center Registry of Pediatric Patients Treated With Radiation Therapy

for Pediatric Patients Treated With Radiation Therapy

24 locations incl. Palo Alto

Sponsor: Massachusetts General Hospital

Sex: All·Age: Up to 21

Code: NCT01696721·Recruiting

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Safety Study of Unlicensed IND Cord Blood Units Manufactured by the National Cord Blood Program for Unrelated Transplantation

for Infusion Reactions

71 locations incl. Birmingham

Sponsor: New York Blood Center

Sex: All·Age: All ages

Code: NCT01656603·Phase 2·Recruiting

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A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

for Hematologic Malignancies

142 locations incl. Birmingham

Sponsor: Center for International Blood and Marrow Transplant Research

Sex: All·Age: All ages

Code: NCT01351545·Recruiting

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A Clinical Trial of Pulsed-dye Laser Versus Timolol Topical Solution Versus Observation on the Growth of Hemangioma in Newborn

for Hemangioma

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: Up to 3 Months·Accepts healthy volunteers

Code: NCT01873131·Recruiting

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North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)

for Mitochondrial Disorders

16 locations incl. San Diego

Sponsor: Columbia University

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT01694940·Recruiting

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Longitudinal Study of the Porphyrias

for Acute Porphyrias

16 locations incl. Birmingham

Sponsor: The American Porphyrias Expert Collaborative

Sex: All·Age: 1 Minute+

Code: NCT01561157·Recruiting

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Prospective Screening for Breast Cancer-related Lymphedema

for Lymphedema

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18+

Code: NCT01521741·Recruiting

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BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia

for Tetraplegia

6 locations incl. Sacramento

Sponsor: Leigh R. Hochberg, MD, PhD.

Sex: All·Age: 18 - 80

Code: NCT00912041·Recruiting

Apply to this trial