Montalcino Aortic Consortium: Precision Medicine for Heritable Thoracic Aortic Disease
Part of paid clinical trials in Newport Beach, California.
- Sponsor
- The University of Texas Health Science Center, Houston
- Study ID
- NCT04005976
- Status
- Recruiting
Conditions
- Aortic Aneurysm
- Aortic Diseases
- Aortic Dissection
Eligibility Criteria
- Sex
- ALL
- Age
- N/A - N/A
- Healthy Volunteers
- Accepted
Study Details
The Montalcino Aortic Consortium (MAC) will provide the infrastructure to assemble large cohorts of patients with mutations in known heritable thoracic aortic disease (H-TAD) genes, define the phenotype associated with these genes, and determine genetic and environmental modifiers of H-TAD.
Key Dates
- Start date
- Jun 15, 2016
- Status verified
- Jan 2026
- Primary completion
- Jan 1, 2037
- Completion
- Jan 1, 2037
Study Design
- Enrollment
- 5,000 participants (estimated)
Arms
- Arm: Patients with causal mutations in the known H-TAD genes
Primary Outcome Measure
Number of participants with aortic dissection [ Time Frame: 20 years ]
Central Contacts
- Dianna M Milewicz, MD, PhD713-500-6725
- Ernesto Calderon Martinez, MD(713) 500-6715
Locations (14)
| Facility | City | State | ZIP | Site coordinators |
|---|---|---|---|---|
| Hoag Memorial Hospital Presbyterian | Newport Beach | California | 92663 | Chelsey Torres, MD |
| HOAG memorial hospital presbyterian | Newport Beach | California | 92663 | Site Investigator 949-650-3350 Rita Weise, MSN, NP, ACNPC-AG 949-650-3350 |
| Sutter Health | Sacramento | California | 95816 | Matthew Solomon, MD |
| University of Kentucky | Lexington | Kentucky | 40536 | Mary Sheppard |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | Mark Lindsay, MD |
| University of Michigan | Ann Arbor | Michigan | 48109 | Marion Hofmann, MD |
| Washington University in St. Louis | St Louis | Missouri | 63110 | Leslie Boyer |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198 | Kelly Erickson |
| St. Francis Hospital (Catholic Health) | Roslyn | New York | 11576 | Timothy Carter |
| Oregon Health & Science University | Portland | Oregon | 97239 | Sherene Shalhub, MD |
| Baylor College of Medicine | Houston | Texas | 77030 | Ginger Etheridge |
| Texas Children's Hospital | Houston | Texas | 77030 | Shaine Morris, MD |
| The University of Texas Health Science Center at Houston | Houston | Texas | 77030 | Program Manager 713-500-7386 |
| Inova Health System | Falls Church | Virginia | 22042 | Christopher Jordan, MD |
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