Biomechanical Precision Medicine Registry for Patients With and Without Heart Failure

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Massachusetts General Hospital
Study ID
NCT03480633
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Study Details

In this single-center, longitudinal observational study, we will comprehensively examine clinical characteristics, proteomic, metabolomic, genomic and imaging data to better understand how different heart failure types may develop and progress over time. We will evaluate distinct sub-groups of heart failure (also known as heart failure phenotypes) and cardiomyopathies including amyloidosis with an ultimate goal of bringing the right medications and therapy to the right patients to optimize benefit and minimized side effects, an effort to improve precision medicine in heart failure.

Key Dates

Start date
Apr 7, 2016
Status verified
Dec 2025
Primary completion
Apr 6, 2026
Completion
Oct 6, 2027

Study Design

Enrollment
3,000 participants (estimated)

Arms

  • Arm: Control
    Defined as patients without a history of heart failure
  • Arm: Heart Failure w/NormalEjectionFraction
    Heart Failure with Normal Ejection Fraction is defined as having a Left Ventricle Ejection Fraction of greater than or equal to 50%.
  • Arm: HeartFailure w/ReducedEjectionFraction
    Heart Failure with Reduced Ejection Fraction is defined as having a Left Ventricle Ejection Fraction of less than 50%.

Primary Outcome Measure

Major adverse cardiovascular events (MACE) [ Time Frame: Time from sample collection until the date of documented event up to 60 months after the study closure. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Massachusetts General HospitalBostonMassachusetts02114
Heather Jameson, PhD
Hanna Gaggin, MD, MPH (PRINCIPAL_INVESTIGATOR)

Find similar trials in Boston, MA

By condition
Heart failure
By specialty
CardiologyHeart disease
By research site
Massachusetts General Hospital· Boston, MA

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