Clinical Trials at Massachusetts General Hospital

As of June 2026, 726 paid clinical trials are recruiting at Massachusetts General Hospital, located at Faustman Lab at Massachusetts General Hospital, 149 13th St #3602, Boston, MA 02129, phone (617) 726-4084 in Boston, Massachusetts. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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726 clinical trials at Massachusetts General Hospital

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The PROGRAM-study: Awake Mapping Versus Asleep Mapping Versus No Mapping for Glioblastoma Resections

for Glioblastoma

2 locations incl. San Francisco

Sponsor: Erasmus Medical Center

Sex: All·Age: 18 - 90

Code: NCT04708171·Recruiting

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The SUPRAMAX Study: Supramaximal Resection Versus Maximal Resection for High-Grade Glioma Patients (ENCRAM 2201)

for Glioblastoma

2 locations incl. San Francisco

Sponsor: Jasper Gerritsen

Sex: All·Age: 18 - 90

Code: NCT06118723·Recruiting

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First-in-Human Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, as a Single Agent in Patients With Advanced Solid Tumors and in Combination With Endocrine Therapy +/- a CDK4/6 or CDK4 Inhibitor in Patients With Advanced Solid Tumors or Advanced Breast Cancer

for PIK3CA Mutation

24 locations incl. Tucson

Sponsor: Relay Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05216432·Phase 1·Recruiting

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Estrogen Administration for the Treatment of NASH in Postmenopausal Women

for NASH - Nonalcoholic Steatohepatitis

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 45 - 70

Code: NCT04833140·Phase 3·Recruiting

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Promoting Well-being and Health in Heart Failure

for Heart Failure

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04829617·Recruiting

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Impact of Intravenous Iron Repletion On Mechanisms of Exercise InTolerance in HFpEF (IRONMET-HFpEF)

for Iron-deficiency

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04945707·Phase 4·Recruiting

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IlluminOss Photodynamic Bone Stabilization System for the Treatment of Impending and Actual Pelvis Fractures

for Cancer Metastatic

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 21+

Code: NCT04842266·Recruiting

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CLN-049 in Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)

for Relapsed/Refractory Acute Myeloid Leukemia (AML)

11 locations incl. Houston

Sponsor: Cullinan Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT05143996·Phase 1·Recruiting

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The Effect of Mindfulness on Vascular Inflammation in Stable Coronary Disease

for Atherosclerosis

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 45 - 65

Code: NCT04505865·Recruiting

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A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)

for Metastatic Colorectal Cancer

35 locations incl. Birmingham

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT04929223·Phase 1·Recruiting

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Global Utilization And Registry Database for Improved preservAtion of doNor LUNGs

for Interstitial Lung Disease

14 locations incl. Phoenix

Sponsor: Paragonix Technologies

Sex: All·Age: All ages

Code: NCT04930289·Enrolling By Invitation

A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Biliary Cholangitis

for Primary Biliary Cholangitis

44 locations incl. Coronado

Sponsor: Mirum Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT05050136·Phase 2·Recruiting

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A Phase 1b/2 Study of Sonrotoclax (BGB-11417) as Monotherapy and in Various Combinations With Dexamethasone Plus Carfilzomib, Dexamethasone Plus Daratumumab, and Dexamethasone Plus Pomalidomide in Multiple Myeloma

for Relapsed/Refractory Multiple Myeloma

Drug: Daratumumab

16 locations incl. Birmingham

Sponsor: BeOne Medicines

Sex: All·Age: 18+

Code: NCT04973605·Phase 1, Phase 2·Recruiting

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ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation

for Bladder Carcinoma

33 locations incl. Birmingham

Sponsor: Guardant Health, Inc.

Sex: All·Age: 18+

Code: NCT05059444·Recruiting

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Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015)

for Pheochromocytoma/Paraganglioma

14 locations incl. Los Angeles

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 12+

Code: NCT04924075·Phase 2·Recruiting

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Extension Study to Evaluate Safety and Tolerability of Oral Dersimelagon (MT-7117) in Subjects With Erythropoietic Protoporphyria (EPP) or X-Linked Protoporphyria (XLP)

for EPP

15 locations incl. Huntington Beach

Sponsor: Tanabe Pharma America, Inc.

Sex: All·Age: 12 - 75

Code: NCT05005975·Phase 3·Recruiting

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Mitral Valve Screening Survey

for Mitral Valve Disease

14 locations incl. Phoenix

Sponsor: Medstar Health Research Institute

Sex: All·Age: 18+

Code: NCT04736667·Recruiting

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Phase 1a and Phase 2 Study for Safety, Preliminary Efficacy, PK and PD of ST-067

for Cancer

6 locations incl. Scottsdale

Sponsor: Simcha IL-18, Inc.

Sex: All·Age: 18+

Code: NCT04787042·Phase 1, Phase 2·Recruiting

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Oxytocin for Weight Loss in Adolescents

for Obesity, Adolescent

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 10 - 18

Code: NCT04551482·Phase 2·Recruiting

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Low-Intensity Focused Ultrasound Pulsation (LIFUP) for the Treatment of Generalized Anxiety Disorder (GAD)

for Generalized Anxiety Disorder

3 locations incl. Los Angeles

Sponsor: University of California, Los Angeles

Sex: All·Age: 18 - 65

Code: NCT04557891·Recruiting

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The Role of Wearable Devices in Predicting and Detecting Complications and Adverse Events

for Recovery

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04824066·Recruiting

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Folfox+Irinotecan+Chemort In Esophageal Cancer

for Gastroesophageal Junction Adenocarcinoma

Drug: Irinotecan

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04656041·Phase 2·Recruiting

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Study of the Long-Term Safety and Outcomes of Treating Pulmonary Embolism With the Indigo Aspiration System

for Pulmonary Embolism

57 locations incl. Long Beach

Sponsor: Penumbra Inc.

Sex: All·Age: 18+

Code: NCT04798261·Recruiting

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A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Participants With Breast Cancer

for Inoperable, Locally Advanced or Metastatic, ER-positive Breast Cancer

12 locations incl. Duarte

Sponsor: Hoffmann-La Roche

Sex: Female·Age: 18+

Code: NCT04802759·Phase 1, Phase 2·Recruiting

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ATEMPT 2.0: Adjuvant T-DM1 vs TH

for Breast Cancer

53 locations incl. San Francisco

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04893109·Phase 2·Recruiting

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Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home Measures

for Amyotrophic Lateral Sclerosis

10 locations incl. Phoenix

Sponsor: Target ALS Foundation, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05137665·Recruiting

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A Phase 1/2 Study of Bleximenib in Participants With Acute Leukemia (cAMeLot-1)

for Acute Leukemia

26 locations incl. Duarte

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 2+

Code: NCT04811560·Phase 1, Phase 2·Recruiting

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Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Aficamten in Adults With HCM

for Symptomatic Hypertrophic Cardiomyopathy (HCM)

Drug: Aficamten

52 locations incl. Birmingham

Sponsor: Cytokinetics

Sex: All·Age: 18 - 85

Code: NCT04848506·Phase 2, Phase 3·Enrolling By Invitation

Vaginal Microbiota Transplant

for Recurrent Bacterial Vaginosis

1 location in Boston

Sponsor: Douglas Kwon

Sex: Female·Age: 18 - 50

Code: NCT04046900·Phase 1, Phase 2·Recruiting

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Computational Neuroscience of Language Processing in the Human Brain

for Language

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 85

Code: NCT05222594·Recruiting

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Intermuscular Coherence as a Biomarker for ALS

for Amyotrophic Lateral Sclerosis

4 locations incl. Irvine

Sponsor: University of Chicago

Sex: All·Age: 20 - 90·Accepts healthy volunteers

Code: NCT05104710·Recruiting

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A Safety, Tolerability, and Efficacy Study of VX-880 in Participants With Type 1 Diabetes

for Diabetes Mellitus, Type 1

12 locations incl. Duarte

Sponsor: Vertex Pharmaceuticals Incorporated

Sex: All·Age: 18 - 65

Code: NCT04786262·Phase 3·Recruiting

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Investigating the Utility of Demyelination Tracer [18F]3F4AP in Controls and Multiple Sclerosis Subjects

for Multiple Sclerosis

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT04699747·Phase 1·Recruiting

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Study to Evaluate VT3989 in Patients With Metastatic Solid Tumors

for Solid Tumor, Adult

9 locations incl. San Francisco

Sponsor: Vivace Therapeutics, Inc

Sex: All·Age: 18+

Code: NCT04665206·Phase 1, Phase 2·Recruiting

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The MITRAL II Pivotal Trial (Mitral Implantation of TRAnscatheter vaLves).

for Mitral Annular Calcification

16 locations incl. Gilbert

Sponsor: Mayra Guerrero

Sex: All·Age: 18+

Code: NCT04408430·Recruiting

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Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY

for Ischemic Stroke

31 locations incl. Phoenix

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04916210·Recruiting

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Auditory Stimulation Effects on Sleep and Memory in Patients With Epilepsy

for Epilepsy

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 12 - 65

Code: NCT04788628·Enrolling By Invitation

SHARON: A Clinical Trial for Metastatic Cancer Using Chemotherapy and Patients' Own Stem Cells

for Pancreatic Adenocarcinoma Metastatic

2 locations incl. Boston

Sponsor: General Oncology, Inc.

Sex: All·Age: 18+

Code: NCT04150042·Phase 1·Recruiting

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A Clinical Trial Investigating the Safety, Tolerability, and Therapeutic Effects of BNT113 in Combination With Pembrolizumab Versus Pembrolizumab Alone for Patients With a Form of Head and Neck Cancer Positive for Human Papilloma Virus 16 and Expressing the Protein PD-L1

for Unresectable Head and Neck Squamous Cell Carcinoma

19 locations incl. Los Angeles

Sponsor: BioNTech SE

Sex: All·Age: 18+

Code: NCT04534205·Phase 2, Phase 3·Recruiting

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Staged Complete Revascularization for Coronary Artery Disease vs Medical Management Alone in Patients With AS Undergoing Transcatheter Aortic Valve Replacement

for Aortic Stenosis

55 locations incl. Huntsville

Sponsor: University of British Columbia

Sex: All·Age: All ages

Code: NCT04634240·Recruiting

Apply to this trial