Auditory Stimulation Effects on Sleep and Memory in Patients With Epilepsy

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Massachusetts General Hospital
Study ID
NCT04788628
Status
Enrolling By Invitation

Conditions

Eligibility Criteria

Sex
ALL
Age
12 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • Baseline — OTHER
    Hippocampal and scalp EEG monitoring during overnight sleep
  • Motor procedural memory task — OTHER
    Training on the finger tapping MST prior to monitored overnight sleep with MST testing the following morning
  • Motor procedural memory task plus auditory stimulation — OTHER
    Training on the finger tapping MST prior to monitored overnight sleep that includes auditory stimulation, with MST testing the following morning

Study Details

This study will investigate the role of coordinated brain rhythms during sleep in memory consolidation and determine whether playing precisely timed brief bursts of noise can enhance these rhythms and improve memory in epilepsy inpatients with implanted hippocampal electrodes.

Key Dates

Start date
Jan 21, 2021
Status verified
Nov 2025
Primary completion
Mar 31, 2026
Completion
Mar 31, 2026

Study Design

Enrollment
24 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Epilepsy inpatients
    Epilepsy inpatients with implanted hippocampal electrodes and continuous scalp EEG monitoring

Primary Outcome Measure

Changes in slow oscillation-spindle-hippocampal ripple coupling [ Time Frame: Three nights of sleep within three weeks ]

Locations (1)

FacilityCityStateZIPSite coordinators
Massachusetts General HospitalBostonMassachusetts02114-

Find similar trials in Boston, MA

By condition
Epilepsy
By specialty
NeurologyBrain disorders
By research site
Massachusetts General Hospital· Boston, MA

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