Clinical Trials at Massachusetts General Hospital

As of June 2026, 726 paid clinical trials are recruiting at Massachusetts General Hospital, located at Faustman Lab at Massachusetts General Hospital, 149 13th St #3602, Boston, MA 02129, phone (617) 726-4084 in Boston, Massachusetts. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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726 clinical trials at Massachusetts General Hospital

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A Study of Peluntamig (PT217) in Patients With Neuroendocrine Carcinomas Expressing DLL3 (the SKYBRIDGE Study)

for Small Cell Lung Cancer (SCLC)

12 locations incl. Duarte

Sponsor: Phanes Therapeutics

Sex: All·Age: 18+

Code: NCT05652686·Phase 1, Phase 2·Recruiting

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Multicenter Trial of Antibiotic Eluting Graft for Promoting New Bone Growth In/near Infected Bone Cavities

for Periprosthetic Joint Infections

12 locations incl. Los Angeles

Sponsor: Elute, Inc.

Sex: All·Age: 22+·Accepts healthy volunteers

Code: NCT05361941·Recruiting

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HELIOS: Open-Label, Long-Term Extension Study to Investigate the Safety, Tolerability, and Efficacy of DISC-1459 (Bitopertin) in Participants With EPP or XLP

for Erythropoietic Protoporphyria

11 locations incl. Birmingham

Sponsor: Disc Medicine, Inc

Sex: All·Age: 12+

Code: NCT05883748·Phase 2, Phase 3·Enrolling By Invitation

Effect of PRP, PPP, & BMAC on Functional Outcomes Following Hip Arthroscopy for Acetabular Labral Pathologies

for Acetabular Labrum Tear

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06003101·Phase 3·Recruiting

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MOLAR: Mapping Oral Health and Local Area Resources

for Dental Diseases

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 1+

Code: NCT05688982·Recruiting

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US National OCS Heart Perfusion (OHP) Registry

for Heart Transplant

37 locations incl. Phoenix

Sponsor: TransMedics

Sex: All·Age: All ages

Code: NCT05915299·Recruiting

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Mapping Auricular Vagus Nerve Circuitry

for Healthy

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT00200889·EARLY_Phase 1·Recruiting

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OCT Vibrography for Biomechanical Properties of Tissues

for Cornea

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT05759780·Recruiting

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Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors

for Non Small Cell Lung Cancer

24 locations incl. Beverly Hills

Sponsor: SystImmune Inc.

Sex: All·Age: 18+

Code: NCT05983432·Phase 1·Recruiting

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Long-term Follow-up of Subjects Treated With CAR T Cells

for Long Term Adverse Effects

1 location in Boston

Sponsor: Marcela V. Maus, M.D.,Ph.D.

Sex: All·Age: 18+

Code: NCT05024175·Recruiting

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Oxytocin Effects on Bone in Children With Autism Spectrum Disorder

for Autism Spectrum Disorder

2 locations incl. Boston

Sponsor: Elizabeth Austen Lawson

Sex: All·Age: 6 - 18

Code: NCT05754073·Phase 2·Recruiting

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A Study to Investigate the Safety and Tolerability of Ziftomenib in Combination With Venetoclax/Azacitidine, Venetoclax, 7+3, or 7+3+Quizartinib in Patients With AML

for Acute Myeloid Leukemia

Drug: Venetoclax

44 locations incl. Phoenix

Sponsor: Kura Oncology, Inc.

Sex: All·Age: 18+

Code: NCT05735184·Phase 1·Recruiting

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A Clinical Study to Assess the Efficacy and Safety of Leriglitazone in Adult Male Subjects With Cerebral Adrenoleukodystrophy

for Cerebral Adrenoleukodystrophy (cALD)

Drug: Leriglitazone

6 locations incl. Palo Alto

Sponsor: Minoryx Therapeutics, S.L.

Sex: Male·Age: 18+

Code: NCT05819866·Phase 3·Recruiting

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Study of Inebilizumab in Pediatric Subjects With Neuromyelitis Optica Spectrum Disorder

for Neuromyelitis Optica Spectrum Disorder

Drug: Inebilizumab

4 locations incl. La Jolla

Sponsor: Amgen

Sex: All·Age: 2 - 17

Code: NCT05549258·Phase 2·Recruiting

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Impact of Cognitive Behavioral Therapy on PTSD-CVD Link

for Posttraumatic Stress Disorder

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT06429293·Recruiting

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A Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-TNF Therapy

for Hidradenitis Suppurativa

Drug: Upadacitinib

87 locations incl. Birmingham

Sponsor: AbbVie

Sex: All·Age: 12+

Code: NCT05889182·Phase 3·Recruiting

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Surgical Treatments for Postamputation Pain

for Residual Limb Pain

3 locations incl. Chicago

Sponsor: Prometei Pain Rehabilitation Center

Sex: All·Age: 18+

Code: NCT05009394·Recruiting

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From Nerve to Brain: Toward a Mechanistic Understanding of Spinal Cord Stimulation in Human Subjects

for Chronic Pain

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 80

Code: NCT05661903·Phase 2·Recruiting

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SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance)

for Glioma

40 locations incl. Birmingham

Sponsor: Nuvation Bio Inc.

Sex: All·Age: 18+

Code: NCT05303519·Phase 3·Recruiting

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Effects of Antiviral Therapies on Epstein-Barr Virus Replication

for Multiple Sclerosis

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05957913·Phase 2·Enrolling By Invitation

Safety and Tolerability of TNG462 in Patients With MTAP-deleted Solid Tumors

for Locally Advanced Solid Tumor

15 locations incl. Palo Alto

Sponsor: Tango Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05732831·Phase 1, Phase 2·Recruiting

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FOG-001 in Locally Advanced or Metastatic Solid Tumors

for Cancer

31 locations incl. Phoenix

Sponsor: Parabilis Medicines, Inc.

Sex: All·Age: 18+

Code: NCT05919264·Phase 1, Phase 2·Recruiting

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Safety and Efficacy of Atorvastatin v. Placebo on HCC Risk

for Liver Fibroses

2 locations incl. Boston

Sponsor: Raymond Chung

Sex: All·Age: 18+

Code: NCT05028829·Phase 2·Recruiting

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Digital Accessible Remote Olfactory Mediated Health Assessments for Preclinical AD

for Subjective Cognitive Concerns

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT05881239·Recruiting

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Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease

for Alzheimer Disease

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 40 - 99·Accepts healthy volunteers

Code: NCT06538311·EARLY_Phase 1·Recruiting

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A Trial to Study if REGN5837 in Combination With Odronextamab is Safe for Adult Participants With Aggressive B-cell Non-Hodgkin Lymphomas

for B-cell Non-Hodgkins Lymphoma (B-NHL)

Drug: Odronextamab

9 locations incl. Duarte

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT05685173·Phase 1·Recruiting

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Salivary Extracellular Vesicle Associated lncRNAs in Heart Failure (SEAL-HF)

for CHF

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06169540·Recruiting

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First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors

for Breast Cancer

28 locations incl. Los Angeles

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT05768139·Phase 1, Phase 2·Recruiting

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Nutrition for Precision Health, Powered by the All of Us

for Nutrition

14 locations incl. Birmingham

Sponsor: RTI International

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05701657·Recruiting

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Investigating Speech Sequencing in Neurotypical Speakers and Persons With Disordered Speech

for Stuttering, Developmental

3 locations incl. Boston

Sponsor: Boston University Charles River Campus

Sex: All·Age: 6+·Accepts healthy volunteers

Code: NCT05437159·Recruiting

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Medically Intensive Nutrition Therapy Program for Obesity and Diabetes in a Low-income Population

for Overweight

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT05799222·Recruiting

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A Study for Imaging the Lower Gastrointestinal Tract Using a Retro-TCE Capsule

for Lynch Syndrome

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT07219537·Recruiting

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A Study of GV20-0251 Monotherapy and GV20-0251 in Combination With Pembrolizumab in Participants With Solid Tumor Malignancies

for Solid Tumor, Adult

13 locations incl. Los Angeles

Sponsor: GV20 Therapeutics

Sex: All·Age: 18+

Code: NCT05669430·Phase 1, Phase 2·Recruiting

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Tau PET/CT Imaging in the Mismatch Prospective Cohort Study (MPC-TAU)

for Alzheimer's Disease

2 locations incl. Boston

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 120

Code: NCT05658913·Recruiting

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A Study of PYX-201 in Advanced Solid Tumors

for Solid Tumor

17 locations incl. Scottsdale

Sponsor: Pyxis Oncology, Inc

Sex: All·Age: 18+

Code: NCT05720117·Phase 1·Recruiting

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An Open-Label Exploratory Study of Fosigotifator in Participants With Vanishing White Matter Disease

for Vanishing White Matter Disease

3 locations incl. Boston

Sponsor: Calico Life Sciences LLC

Sex: All·Age: 6 Months+

Code: NCT05757141·Phase 1, Phase 2·Recruiting

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A Study to Assess the Long-Term Safety and Efficacy of Lebrikizumab (LY3650150) in Participants 6 Months to <18 Years of Age With Moderate-to-Severe Atopic Dermatitis

for Atopic Dermatitis

21 locations incl. Birmingham

Sponsor: Eli Lilly and Company

Sex: All·Age: 6 Months - 18

Code: NCT05735483·Phase 3·Enrolling By Invitation

Cardiac Resynchronization Therapy Delivery Guided Non-Invasive Electrical and Venous Anatomy Assessment

for Cardiac Resynchronization Therapy

4 locations incl. Chicago

Sponsor: XSpline S.p.A.

Sex: All·Age: 18+

Code: NCT05327062·Recruiting

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Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIV

for Major Depressive Disorder

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 85

Code: NCT05570812·Phase 2·Recruiting

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The GORE® VIABAHN® FORTEGRA Venous Stent Iliofemoral Study

for Venous Thromboses

27 locations incl. Stanford

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18+

Code: NCT05489588·Recruiting

Apply to this trial