RecruitingPhase 2Drug trialNeuroactive Steroid to Treat Depressed Mood: A Trial for People With HIVThis study will determine the effects of pregnenolone on brain function, inflammation and depressive symptoms in people with HIV who have depression. Participants in this study will receive a pill of either pregnenolone or placebo, and can stay on their current antidepression medications. Brain imaging and behavioral assessments will be performed during the study.