Clinical Trials at Massachusetts General Hospital

As of June 2026, 726 paid clinical trials are recruiting at Massachusetts General Hospital, located at Faustman Lab at Massachusetts General Hospital, 149 13th St #3602, Boston, MA 02129, phone (617) 726-4084 in Boston, Massachusetts. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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Healthy volunteers only

726 clinical trials at Massachusetts General Hospital

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A Study of Ficlatuzumab in Combination With Cetuximab in Participants With Recurrent or Metastatic (R/M) HPV Negative Head and Neck Squamous Cell Carcinoma

for Metastatic Head-and-neck Squamous-cell Carcinoma

28 locations incl. Gilbert

Sponsor: AVEO Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT06064877·Phase 3·Recruiting

Apply to this trial

Gamma Light and Sound Stimulation to Prevent Dementia in Cognitively Normal People At Risk for Alzheimer's Disease

for Alzheimer Disease

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 55 - 90·Accepts healthy volunteers

Code: NCT05776641·Recruiting

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Hyperbaric Oxygen Therapy for Ulcerative Colitis (HBOT-UC)

for Ulcerative Colitis

13 locations incl. Birmingham

Sponsor: Northwestern University

Sex: All·Age: 18 - 85

Code: NCT05987852·Recruiting

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A Global Study of the PETAL Consortium

for T-Cell and NK-Cell Neoplasm

10 locations incl. Duarte

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06067347·Recruiting

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PrProfile: A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ION717

for Prion Disease

3 locations incl. Boston

Sponsor: Ionis Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT06153966·Phase 1, Phase 2·Recruiting

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National Liver Cancer Screening Trial

for Carcinoma, Hepatocellular

18 locations incl. Los Angeles

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18 - 85

Code: NCT06084234·Phase 4·Recruiting

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ART-Pro: Clinical Trial Evaluating Biparametric MRI and Advanced, Quantitative Diffusion MRI for Detection of Prostate Cancer

for Prostate Cancer

4 locations incl. San Diego

Sponsor: University of California, San Diego

Sex: Male·Age: 18+

Code: NCT06579417·Recruiting

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Safety and Effectiveness of Pulmonary Vein isOLation And posterioR Wall Ablation wIth pulSed Field Energy in Patients With Paroxysmal and Persistent AF

for Atrial Fibrillation

6 locations incl. Jonesboro

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 80

Code: NCT06099730·Recruiting

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A Study to Assess Adverse Events, Change in Disease Activity, and How Intravenous and Subcutaneous Risankizumab Moves Through the Body of Pediatric Participants With Moderately to Severely Active Crohn's Disease

for Crohn's Disease

Drug: Risankizumab

11 locations incl. Phoenix

Sponsor: AbbVie

Sex: All·Age: 2 - 17

Code: NCT05995353·Phase 3·Recruiting

Apply to this trial

Zenith® Fenestrated+ Clinical Study

for Aortic Aneurysm, Abdominal

32 locations incl. Birmingham

Sponsor: Cook Research Incorporated

Sex: All·Age: 18+

Code: NCT04875429·Recruiting

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Polygenic Risk-based Detection of Subclinical Coronary Atherosclerosis and Change in Cardiovascular Health

for Coronary Artery Disease

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 40 - 75

Code: NCT05819814·Recruiting

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Polygenic Risk-based Detection of Subclinical Coronary Atherosclerosis and Intervention With Statin and Colchicine

for Coronary Artery Disease

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 40 - 75

Code: NCT05850091·Phase 4·Recruiting

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Middle Meningeal Artery Embolization (MMAE) Outcomes for Chronic Subdural Hematoma (cSDH)

for Chronic Subdural Hematoma

15 locations incl. Coral Gables

Sponsor: Montefiore Medical Center

Sex: All·Age: 18+

Code: NCT06181994·Recruiting

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Impact of Sex and Age on Non-visual Light Input That Affects Sleep and Circadian Rhythms

for Normal Physiology

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT05829044·Recruiting

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Evaluation of the GORE® Ascending Stent Graft

for Aortic Aneurysm, Thoracic

41 locations incl. Birmingham

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18+

Code: NCT05800743·Enrolling By Invitation

Safety and Anti-Tumor Activity of TYRA-200 in Advanced Cholangiocarcinoma With Activating FGFR2 Gene Alterations

for Locally Advanced Cholangiocarcinoma

4 locations incl. San Francisco

Sponsor: Tyra Biosciences, Inc

Sex: All·Age: 18+

Code: NCT06160752·Phase 1·Recruiting

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A Randomized Clinical Trial of a Novel Drug Education and Diversion Program (iDECIDE) for Middle and High School Students

for Substance Use

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 9 - 22

Code: NCT06115746·Recruiting

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Comprehensive HHT Outcomes Registry of the United States (CHORUS)

for Hereditary Hemorrhagic Telangiectasia

16 locations incl. Birmingham

Sponsor: Cure HHT

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT06259292·Recruiting

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Preventing Childbirth-Related PTSD With Expressive Writing

for PTSD (Childbirth-Related)

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18 - 50·Accepts healthy volunteers

Code: NCT05662423·Recruiting

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Circuit-Based Approach to Suicide: Biomarkers, Predictors, and Novel Therapeutics

for Major Depressive Episode

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT04130958·Recruiting

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Evaluation of Lasofoxifene Combined With Abemaciclib Compared With Fulvestrant Combined With Abemaciclib in Locally Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation

for Metastatic Breast Cancer

36 locations incl. Scottsdale

Sponsor: LeonaBio

Sex: All·Age: 18+

Code: NCT05696626·Phase 3·Recruiting

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Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF)

for Progressive Pulmonary Fibrosis

70 locations incl. Birmingham

Sponsor: United Therapeutics

Sex: All·Age: 18+

Code: NCT05943535·Phase 3·Recruiting

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Ultrasound-Guided Percutaneous Cryoneurolysis to Treat Pain Following Thoracic Trauma

for Rib Fracture

5 locations incl. La Jolla

Sponsor: University of California, San Diego

Sex: All·Age: 18+

Code: NCT06069154·Enrolling By Invitation

CD79b-19 CAR T Cells in Non-Hodgkin Lymphoma

for Non-hodgkin Lymphoma

1 location in Boston

Sponsor: Marcela V. Maus, M.D.,Ph.D.

Sex: All·Age: 18+

Code: NCT06026319·Phase 1·Recruiting

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Nectero EAST System Clinical Study

for Abdominal Aortic Aneurysm

37 locations incl. Scottsdale

Sponsor: Nectero Medical, Inc.

Sex: All·Age: 21 - 85

Code: NCT06001918·Phase 2, Phase 3·Recruiting

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Long-Term Safety and Efficacy of Tegoprubart in Kidney Transplant Recipients

for Kidney Transplant Rejection

26 locations incl. Los Angeles

Sponsor: Eledon Pharmaceuticals

Sex: All·Age: 18 - 100

Code: NCT06126380·Phase 2·Enrolling By Invitation

Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia

for Anarthria

2 locations incl. Stanford

Sponsor: Leigh R. Hochberg, MD, PhD.

Sex: All·Age: 18 - 80

Code: NCT05724173·Recruiting

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PRIMARY Ancillary Substudy

for Mitral Valve Prolapse

16 locations incl. Los Angeles

Sponsor: Annetine Gelijns

Sex: All·Age: 60+

Code: NCT07103733·Recruiting

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Study of Efficacy and Safety of Iptacopan in Participants With IC-MPGN

for IC-MPGN

Drug: Iptacopan

22 locations incl. Los Angeles

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 12 - 60

Code: NCT05755386·Phase 3·Recruiting

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Supplemental Oxygen in Pulmonary Embolism (SO-PE)

for Pulmonary Embolism

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05891886·EARLY_Phase 1·Recruiting

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Comparative Effectiveness of ECT vs. KETAMINE Over the Lifespan

for Acute Suicidal Depression (ASD)

9 locations incl. San Francisco

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 90

Code: NCT06034821·Phase 4·Enrolling By Invitation

Patient-centered, Optimal Integration of Survivorship and Palliative Care

for Stage IV Non-small Cell Lung Cancer

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04900935·Recruiting

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An Informational and Supportive Care Intervention for Patients With Locally Advanced Rectal Cancer

for Rectal Cancer

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05914766·Recruiting

Apply to this trial

LiverPAL: A Trial of Inpatient Palliative Care for Patients With Advanced Liver Disease

for Liver Disease Chronic

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05998330·Recruiting

Apply to this trial

CTSN Embolic Protection Trial

for Delirium

24 locations incl. North Little Rock

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 60+

Code: NCT06027788·Recruiting

Apply to this trial

Left vs Left Randomized Clinical Trial

for Heart Failure

57 locations incl. Gilbert

Sponsor: Baylor College of Medicine

Sex: All·Age: 18+

Code: NCT05650658·Recruiting

Apply to this trial

Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial

for Surgery-Complications

20 locations incl. Little Rock

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT05991453·Recruiting

Apply to this trial

Sleep and Circadian Rhythm Biomarkers of Postoperative Delirium

for Delirium, Postoperative

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 70+

Code: NCT06052397·Recruiting

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Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

for Non-small Cell Lung Cancer (NSCLC)

17 locations incl. Sacramento

Sponsor: Revolution Medicines, Inc.

Sex: All·Age: 18+

Code: NCT06040541·Phase 1·Recruiting

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Seladelpar in Subjects With Primary Biliary Cholangitis (PBC) and Compensated Cirrhosis

for Primary Biliary Cholangitis

49 locations incl. Birmingham

Sponsor: Gilead Sciences

Sex: All·Age: 18+

Code: NCT06051617·Phase 3·Recruiting

Apply to this trial