Clinical Trials at Brigham and Women's Hospital

As of June 2026, 366 paid clinical trials are recruiting at Brigham and Women's Hospital, located at 75 FRANCIS ST, BOSTON, MA 02115-6110, phone (617) 525-7104 in Boston, Massachusetts. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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366 clinical trials at Brigham and Women's Hospital

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Computerized Decision Support for Identification and Management of Familial Hypercholesterolemia

for Familial Hypercholesterolaemia

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: All ages

Code: NCT06743659·Recruiting

Apply to this trial

A Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease

for Moderately to Severely Active Crohns Disease

Drug: Afimkibart

92 locations incl. Dothan

Sponsor: Hoffmann-La Roche

Sex: All·Age: 16 - 80

Code: NCT06819878·Phase 3·Recruiting

Apply to this trial

Alleviant ALLAY-HFrEF Study

for Heart Failure

35 locations incl. Los Angeles

Sponsor: Alleviant Medical, Inc.

Sex: All·Age: 18+

Code: NCT06812533·Enrolling By Invitation

Azenosertib in Uterine Serous Carcinoma: Biomarker Study

for Uterine Serous Carcinoma

2 locations incl. Boston

Sponsor: Joyce Liu, MD

Sex: Female·Age: 18+

Code: NCT06369155·Phase 2·Recruiting

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Marginal Ulcer Healing With Low-Thermal Argon Plasma Endoscopic Treatment

for Roux-en-y Anastomosis Site

1 location in Boston

Sponsor: Christopher C. Thompson, MD, MSc

Sex: All·Age: 18+

Code: NCT06543316·Recruiting

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Nasal Foralumab in Patients With Non-Active Secondary Progressive Multiple Sclerosis

for Non-Active Secondary Progressive Multiple Sclerosis

Drug: Foralumab

1 location in Boston

Sponsor: Tiziana Life Sciences LTD

Sex: All·Age: 18 - 75

Code: NCT06890923·Phase 2·Recruiting

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A Phase 2 Study of YA-101 in Patients With Multiple System Atrophy

for Multiple System Atrophy

6 locations incl. Los Angeles

Sponsor: Dasher Neuroscience Inc.

Sex: All·Age: 30+

Code: NCT06848231·Phase 2·Recruiting

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A Phase 2 Trial of Ivonescimab for Patients With Advanced, Metastatic Salivary Gland Cancers

for Salivary Gland Cancer

Drug: Ivonescimab

2 locations incl. Boston

Sponsor: Glenn J. Hanna

Sex: All·Age: 18+

Code: NCT06805617·Phase 2·Recruiting

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A Surgical Window of Opportunity Clinical Trial of Troriluzole in Recurrent IDH Wild-Type Glioblastoma

for Glioblastoma

3 locations incl. Boston

Sponsor: Ugonma Chukwueke

Sex: All·Age: 18+

Code: NCT06552260·EARLY_Phase 1·Recruiting

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The Anabolic Effect of Testosterone on Pelvic Floor Muscles

for Stress Urinary Incontinence

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: Female·Age: 60+

Code: NCT06111209·Phase 2·Recruiting

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Apple Health Study

for Mental Health

2 locations incl. Washington D.C.

Sponsor: Apple Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06958523·Recruiting

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Phase 1a Single Ascending Dose Study of MIB-725 in Healthy Adults

for Healthy Adults

1 location in Boston

Sponsor: Metro International Biotech, LLC

Sex: All·Age: 19 - 60·Accepts healthy volunteers

Code: NCT06815991·Phase 1·Recruiting

Apply to this trial

REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE

for Aortic Stenosis

71 locations incl. Birmingham

Sponsor: Medtronic Cardiovascular

Sex: All·Age: 18 - 105

Code: NCT06777368·Recruiting

Apply to this trial

A Study to Test Whether Spesolimab Helps People With a Skin Condition Called Pyoderma Gangrenosum

for Pyoderma Gangrenosum

19 locations incl. Birmingham

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06624670·Phase 3·Recruiting

Apply to this trial

StrokeNet Thrombectomy Endovascular Platform

for Ischemic Stroke

41 locations incl. Birmingham

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT06289985·Recruiting

Apply to this trial

Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness

for Major Depressive Disorder

2 locations incl. Sunnyvale

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 65

Code: NCT06376734·Phase 2·Recruiting

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Phase 1/2 Trial to Evaluate the Safety and Efficacy of PEEL-224 in Combination With Vincristine and Temozolomide in Adolescents and Young Adults With Relapsed or Refractory Sarcomas

for Sarcoma

3 locations incl. Boston

Sponsor: David S Shulman, MD

Sex: All·Age: 12 - 49

Code: NCT06709495·Phase 1, Phase 2·Recruiting

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Synergy Between Patient and Clinician: Using a Trauma-Informed Care Plan

for Trauma and Stressor Related Disorders

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT06330753·Enrolling By Invitation

Embolization Treatment of Chronic Refractory Shoulder Tendinopathy

for Shoulder Pain

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 21 - 80

Code: NCT06095050·Recruiting

Apply to this trial

Post Market Study for VasQ, an External Support Implant for Arteriovenous Fistula

for End Stage Renal Disease

7 locations incl. Long Beach

Sponsor: Laminate Medical Technologies

Sex: All·Age: 18 - 80

Code: NCT06516653·Recruiting

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Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep (MINDDS II)

for Delirium

14 locations incl. Los Angeles

Sponsor: Massachusetts General Hospital

Sex: All·Age: 60+

Code: NCT06192615·Phase 3·Recruiting

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The Effect of Thalamic Stimulation on Sleep Oscillations

for Sleep

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 5 - 85

Code: NCT07217080·Enrolling By Invitation

Phase II Study of RP2 as Immunoprevention in High-Risk Oral Precancerous Disease

for High-Risk Oral Precancerous Disease

2 locations incl. Boston

Sponsor: Glenn J. Hanna

Sex: All·Age: 18+

Code: NCT06623110·Phase 2·Recruiting

Apply to this trial

Leveraging Social Networks to Improve Sleep and Mindfulness Among Older Adults in Residential Housing Facilities

for Aging

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 55+·Accepts healthy volunteers

Code: NCT06989619·Recruiting

Apply to this trial

Belzutifan in Recurrent Clear Cell Carcinoma of Gynecologic Origin

for Ovarian Cancer

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: Female·Age: 18+

Code: NCT06677190·Phase 2·Recruiting

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The Impact of PReOPerative Exercise and NutritionaL Optimization on Perioperative Outcomes for Patients Undergoing Treatment for Rectal Cancer: The PROPEL Trial

for Rectal Cancer

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT06565052·Recruiting

Apply to this trial

Can Food Timing Reduce Your Diabetes Risk?

for Dietary Habits

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT05862818·Recruiting

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A Study to Learn About a Study Medicine Called Ibuzatrelvir in Adult and Adolescent Patients With COVID-19 Who Are Not Hospitalized But Are at Risk For Severe Disease

for COVID-19 SARS-CoV-2 Infection

84 locations incl. Little Rock

Sponsor: Pfizer

Sex: All·Age: 12+

Code: NCT06679140·Phase 3·Recruiting

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A Prospective, US-based Study Assessing Mogamulizumab-associated Rash in Patients Diagnosed With Mycosis Fungoides or Sezary Syndrome and Treated With Standard of Care Mogamulizumab

for Recurrent Mycosis Fungoides

10 locations incl. Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07003100·Recruiting

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Validation of a Novel Cerebellar-striatal Satiety Circuit in Humans

for Appetitive Behavior

2 locations incl. Belmont

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT06105164·Recruiting

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Evaluation of the Safety and Effectiveness of the CereVasc® eShunt® System in Normal Pressure Hydrocephalus

for Normal Pressure Hydrocephalus

28 locations incl. Los Angeles

Sponsor: CereVasc Inc

Sex: All·Age: 60+

Code: NCT06498960·Recruiting

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A Phase 0 Window of Opportunity Trial of Intratumoral Seasonal Influenza Immunization in Cutaneous Squamous Cell Carcinoma (CSCC) Patients Awaiting Curative Excision

for Skin Cancer

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT06664151·EARLY_Phase 1·Recruiting

Apply to this trial

Virtual Reality to Combat Weight-Based Implicit Bias: BWH Pilot Study

for Implicit Bias

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07283523·Enrolling By Invitation

Avelumab and M1774 in ARID1A-mutated Endometrial Cancer

for Endometrial Cancer

2 locations incl. Boston

Sponsor: Panagiotis Konstantinopoulos, MD, PhD

Sex: Female·Age: 18+

Code: NCT06518564·Phase 2·Recruiting

Apply to this trial

Xeltis Hemodialysis Access Graft (aXess) US Study

for End Stage Renal Disease

7 locations incl. Phoenix

Sponsor: Xeltis

Sex: All·Age: 18+

Code: NCT06494631·Enrolling By Invitation

Eating to Adjust the Timing System

for Dietary Intervention

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT05800990·Recruiting

Apply to this trial

Chronic Subdural Hematoma Treatment With Embolization Versus Surgery Study

for Chronic Subdural Hematoma

31 locations incl. Phoenix

Sponsor: The University of Texas Medical Branch, Galveston

Sex: All·Age: 40 - 90

Code: NCT06347796·Recruiting

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Elotuzumab + Iberdomide + Dexamethasone Post Ide-Cel in RRMM

for Myeloma

Drug: Iberdomide

3 locations incl. Boston

Sponsor: Omar Nadeem, MD

Sex: All·Age: 18+

Code: NCT06518551·Phase 1, Phase 2·Recruiting

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Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID

for Long COVID

Drug: Baricitinib

17 locations incl. Tucson

Sponsor: Wes Ely

Sex: All·Age: 18+

Code: NCT06631287·Phase 3·Recruiting

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Pembrolizumab + Chemotherapy in Newly Diagnosed PCNSL

for Lymphoma

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT06475235·Phase 1·Recruiting

Apply to this trial