The Effect of Thalamic Stimulation on Sleep Oscillations

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Massachusetts General Hospital
Study ID
NCT07217080
Status
Enrolling By Invitation

Conditions

  • Neuromodulation
  • Sleep

Eligibility Criteria

Sex
ALL
Age
5 Years - 85 Years
Healthy Volunteers
Not accepted

Interventions

  • Effect of Electrical Stimulation on Sleep — BEHAVIORAL
    Direct electrical stimulation of thalamic nuclei and cortical structures using clinically implanted depth electrodes will allow assessing the effect of stimulation on sleep oscillations.

Study Details

The thalamus plays a key role in supporting sleep and is also a target of therapeutic stimulation. This project investigates when, where, and how electrical stimulation delivered to the thalamus in humans elicits or disrupts sleep oscillations. This research is a first step to better understand how current neuromodulation therapies affect sleep and may help advance toward new therapies to improve sleep for a wide range of neurological and neuropsychological disorders.

Key Dates

Start date
Jan 6, 2025
Status verified
Oct 2025
Primary completion
Nov 30, 2029
Completion
Nov 30, 2029

Study Design

Enrollment
50 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Thalamic stimulation to evoke or disrupt sleep spindles
    Stimulation of thalamic nuclei and cortical structures using electrical stimulation.

Primary Outcome Measure

Change from pre-stimulation baseline of sleep spindle rate [ Time Frame: 10 to 3000 milliseconds following stimulation ]

Locations (2)

FacilityCityStateZIPSite coordinators
Brigham and Women's HospitalBostonMassachusetts02114-2696-
Massachusetts General HospitalBostonMassachusetts02114-2696-

Find similar trials in Boston, MA

By research site
Brigham and Women's Hospital· Boston, MAMassachusetts General Hospital· Boston, MA

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