Brain disorders Clinical Trials in Boston, MA

As of June 2026, 149 paid clinical trials are recruiting for Brain disorders in Boston, Massachusetts. Brain disorder trials span neurodegenerative diseases, stroke, traumatic brain injury, and neuromuscular conditions — testing both pharmacologic and rehabilitative approaches to slow progression and improve function. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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149 clinical trials for Brain disorders

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Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

for Cognitive Impairment, Mild

102 locations incl. Birmingham

Sponsor: Duke University

Sex: All·Age: 75+·Accepts healthy volunteers

Code: NCT04262206·Phase 4·Recruiting

Apply to this trial

PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort

for Parkinson Disease

30 locations incl. Birmingham

Sponsor: Michael J. Fox Foundation for Parkinson's Research

Sex: All·Age: 30+·Accepts healthy volunteers

Code: NCT04477785·Recruiting

Apply to this trial

HEALEY ALS Platform Trial - Master Protocol

for Amyotrophic Lateral Sclerosis

81 locations incl. Phoenix

Sponsor: Merit E. Cudkowicz, MD

Sex: All·Age: 18+

Code: NCT04297683·Phase 2, Phase 3·Recruiting

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Statins In Intracerbral Hemorrhage

for Intracerebral Hemorrhage

1 location in Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 50+

Code: NCT03936361·Phase 3·Recruiting

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ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

for Frontotemporal Lobar Degeneration (FTLD)

25 locations incl. Birmingham

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04363684·Recruiting

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Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

for Intracerebral Hemorrhage

187 locations incl. Birmingham

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT03907046·Phase 3·Recruiting

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Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

for Atrial Fibrillation

51 locations incl. Little Rock

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 18+

Code: NCT04045665·Phase 3·Recruiting

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Registry of Participants With Generalized Myasthenia Gravis Treated With Alexion C5 Inhibition Therapies (C5ITs)

for Generalized Myasthenia Gravis

32 locations incl. Birmingham

Sponsor: Alexion Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT04202341·Recruiting

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Abbott DBS Post-Market Study of Outcomes for Indications Over Time

for Movement Disorders

23 locations incl. Tucson

Sponsor: Abbott Medical Devices

Sex: All·Age: All ages

Code: NCT04071847·Recruiting

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Stroke Thrombectomy and Aneurysm Registry

for Stroke

54 locations incl. Birmingham

Sponsor: Medical University of South Carolina

Sex: All·Age: 1 - 120

Code: NCT04994756·Recruiting

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GORE® CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients With Patent Foramen Ovale (PFO): the REDUCE Post Approval Study

for Stroke

45 locations incl. Tucson

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18 - 70

Code: NCT03821129·Recruiting

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Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO

for Autoimmune Disease

Drug: Nivolumab

51 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT03816345·Phase 1·Recruiting

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Prevalence and Impact of Obstructive Sleep Apnea in Multiple Sclerosis

for Multiple Sclerosis

1 location in Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18+

Code: NCT04603196·Recruiting

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Study of Gastrointestinal Dysfunction and Enteric Neural Pathology in Patients With Parkinson's Disease

for Parkinson Disease

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 40 - 85

Code: NCT04566341·Enrolling By Invitation

Epilepsy Learning Healthcare System (ELHS)

for Epilepsy

13 locations incl. Phoenix

Sponsor: Epilepsy Foundation of America

Sex: All·Age: All ages

Code: NCT06265103·Recruiting

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North American Prodromal Synucleinopathy Consortium

for REM Sleep Behavior Disorder

9 locations incl. Sun City

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT03623672·Enrolling By Invitation

Longitudinal Early-onset Alzheimer's Disease Study Protocol

for Early Onset Alzheimer Disease

18 locations incl. Sun City

Sponsor: Indiana University

Sex: All·Age: 40 - 64·Accepts healthy volunteers

Code: NCT03507257·Recruiting

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Molecular Imaging of NET Using [C-11]MRB-PET in MS

for Multiple Sclerosis

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT03207464·Phase 1, Phase 2·Recruiting

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Genes and Environment in Multiple Sclerosis

for Multiple Sclerosis

5 locations incl. Bethesda

Sponsor: Columbia University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT01353547·Recruiting

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Stroke Motor Rehabilitation and Recovery Study

for Stroke, Ischemic

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 90

Code: NCT03485040·Recruiting

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PET Brain Imaging in Multiple Sclerosis, Alzheimer's Disease, and Other Neurological and Neuropsychiatric Diseases

for Multiple Sclerosis

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT02649985·Phase 1, Phase 2·Recruiting

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Gait Analysis in Neurological Disease

for Parkinson's Disease

1 location in Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT02994719·Recruiting

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Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations

for Traumatic Brain Injury

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT04296604·Recruiting

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Registry of Deep Brain Stimulation With the VERCISE™ System: Vercise DBS Registry

for Parkinson's Disease

28 locations incl. Aliso Viejo

Sponsor: Boston Scientific Corporation

Sex: All·Age: 18+

Code: NCT02071134·Recruiting

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Natural History Study of Synucleinopathies

for Patients With Synucleinopathies

5 locations incl. Boston

Sponsor: NYU Langone Health

Sex: All·Age: 18+

Code: NCT01799915·Recruiting

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Genetics of Epilepsy and Related Disorders

for Epilepsy

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: All ages

Code: NCT01858285·Recruiting

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BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia

for Tetraplegia

6 locations incl. Sacramento

Sponsor: Leigh R. Hochberg, MD, PhD.

Sex: All·Age: 18 - 80

Code: NCT00912041·Recruiting

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Dominantly Inherited Alzheimer Network (DIAN)

for Alzheimer's Disease

8 locations incl. Jacksonville

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT00869817·Recruiting

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Human Epilepsy Genetics--Neuronal Migration Disorders Study

for Brain Malformation

1 location in Boston

Sponsor: Harvard University Faculty of Medicine

Sex: All·Age: All ages

Code: NCT00041600·Recruiting

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Conditions in Brain disorders (Boston, MA)

Stroke· 29 Alzheimer's disease· 22 Parkinson's disease· 22 Epilepsy· 17 Multiple sclerosis· 16 ALS (amyotrophic lateral sclerosis)· 15 Mild cognitive impairment (MCI)· 12 Dementia· 10 Cognitive impairment / decline· 9 Myasthenia gravis· 7 Traumatic brain injury (TBI)· 5 Essential tremor· 4 Huntington disease· 3