Clinical Trials at University of Alabama at Birmingham

As of June 2026, 349 paid clinical trials are recruiting at University of Alabama at Birmingham, located at 619 19TH ST S, BIRMINGHAM, AL 35249-0001, phone (205) 934-6249 in Birmingham, Alabama. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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349 clinical trials at University of Alabama at Birmingham

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A Study of Imlunestrant (LY3484356) in Premenopausal Women With Estrogen Receptor-Positive (ER+) Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Early Breast Cancer

for Breast Neoplasms

25 locations incl. Birmingham

Sponsor: Eli Lilly and Company

Sex: Female·Age: 18+

Code: NCT07287098·Phase 2·Not Yet Recruiting

High-energy Human Milk Diets in the First Two Weeks After Birth to Reduce BPD in Extremely Preterm Infants

for Extreme Prematurity

1 location in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 1 Day - 3 Days

Code: NCT07307612·Phase 1, Phase 2·Not Yet Recruiting

Glucose Metabolism in Cystic Fibrosis Related Diabetes (CFRD)

for Cystic Fibrosis Related Diabetes

1 location in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 21 - 75

Code: NCT07102043·Recruiting

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A Non-inferiority Pharmacokinetic and Safety/Tolerability Study of Two Different Doses of Weekly SC Alpha1-PI 15% Compared With Corresponding Standard IV Alpha1-PI in Participants With Alpha1-Antitrypsin Deficiency (AATD)

for Alpha 1 Antitrypsin Deficiency

10 locations incl. Birmingham

Sponsor: Grifols Therapeutics LLC

Sex: All·Age: 18 - 80

Code: NCT07555483·Phase 3·Recruiting

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Boosting Olfactory and Sensory Training Study (BOOST)

for HIV (Human Immunodeficiency Virus)

1 location in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 40+

Code: NCT07221123·Phase 2·Recruiting

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Folic Acid Salt Study (FISFA Zambia)

for Folate Deficiency

1 location in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: Female·Age: 18 - 45·Accepts healthy volunteers

Code: NCT06734611·Not Yet Recruiting

Pycnogenol (French Maritime Pine Bark) for the Treatment of Gulf War Illness

for Gulf War Syndrome

1 location in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: Male·Age: 18+

Code: NCT07266571·Not Yet Recruiting

Understanding the Impact of Meal Timing on Neurological Health in Adults With Multiple Sclerosis

for Multiple Sclerosis

1 location in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18 - 64

Code: NCT07475377·Not Yet Recruiting

Evaluating an Interactive Digital Toolkit for Women's PrEP Implementation

for HIV Prevention

4 locations incl. Birmingham

Sponsor: University of Alabama at Birmingham

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT07292584·Not Yet Recruiting

Cocoa to Maximize Exercise Training in Older Adults - The COMET Trial

for Mobility Disability

1 location in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 55+

Code: NCT07161726·Phase 1, Phase 2·Recruiting

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Effects of Oral Tranexamic Acid on Short Term Postoperative Outcomes Following Total Shoulder Arthroplasty

for Shoulder Arthroplasty

1 location in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18 - 79

Code: NCT06902714·Phase 3·Recruiting

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Wearable Integration in Symptom Evaluation for Cancer Survivors

for Cancer

1 location in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18+

Code: NCT07463547·Enrolling By Invitation

Bowel Continence Across the Lifespan in People With Spina Bifida

for Spina Bifida

24 locations incl. Birmingham

Sponsor: David Chu

Sex: All·Age: 5+

Code: NCT07390318·Recruiting

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Signatera-Guided CDK4/6 Inhibitor Therapy in Breast Cancer

for Breast Neoplasms

39 locations incl. Birmingham

Sponsor: Natera, Inc.

Sex: All·Age: 18+

Code: NCT07214532·Recruiting

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A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes

for Obesity or Overweight

Drug: Enicepatide

25 locations incl. Anniston

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT07351045·Phase 3·Recruiting

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To Compare Post-Extraction Use of a Novel Ethylenediaminetetraacetic Acid (EDTA) Post-operative Mouth Rinse and Daily Use EDTA Mouth Rinse and Standard 0.12% Chlorhexidine (CHX) Post-operative Mouth Rinse and Daily Use Essential Oil (EO) Mouth Rinse.

for Extraction Sites After Removal and Bone Replacement Grafting at Extraction Sockets of Dentally Hopeless Single-rooted Teeth

1 location in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT07191262·Recruiting

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Brain Uptrain to Improve Learning and Development

for Term Infant

1 location in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 1 Day - 7 Days

Code: NCT06638801·Recruiting

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Early Time-Restricted Eating in Older Adults With Hypertension

for Hypertension

1 location in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 60+

Code: NCT07135505·Recruiting

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PrOTECT AL: PrEP Optimization Through Enhanced Continuum Tracking

for HIV

1 location in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18+

Code: NCT07231640·Recruiting

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Study of BMS-986453 in Newly Diagnosed Multiple Myeloma

for Multiple Myeloma

1 location in Birmingham

Sponsor: Susan Bal

Sex: All·Age: 19+

Code: NCT07333261·Phase 1·Recruiting

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A Double-blind, Randomized Controlled Trial to Investigate the Efficacy, Safety, and Pharmacokinetics of Pegloticase Administration Via Subcutaneous and Intravenous Routes Both With Methotrexate in Participants With Uncontrolled Gout

for Uncontrolled Gout

48 locations incl. Birmingham

Sponsor: Amgen

Sex: All·Age: 18+

Code: NCT07388498·Phase 3·Recruiting

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Early Life Exposures Among Children With Sickle Cell Disease

for Sickle Cell Disease

1 location in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: Female·Age: 18 - 50

Code: NCT05377372·Recruiting

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Allogeneic HB-adMSCs vs Placebo for the Treatment of Acute Kidney Injury

for Acute Kidney Injury

3 locations incl. Birmingham

Sponsor: Hope Biosciences LLC

Sex: All·Age: 18 - 75

Code: NCT06654193·Phase 1, Phase 2·Recruiting

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Investigating the Utility of Augmented Reality Assistance for Ultrasound-Guided Vascular Access

for Vascular Access

1 location in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 5+

Code: NCT07208071·Recruiting

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HIV, Equity, and Addiction Training (HEAT) Program

for Substance Use Disorders

1 location in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18+

Code: NCT06370481·Recruiting

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A Phase II Study of Pemigatinib Plus Durvalumab in Previously Treated Advanced Intrahepatic Cholangiocarcinoma Patients With FGFR-2 Fusion or Rearrangement

for Intrahepatic Cholangiocarcinoma

Drug: Durvalumab

2 locations incl. Birmingham

Sponsor: Mehmet Akce

Sex: All·Age: 18+

Code: NCT06728410·Phase 2·Recruiting

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A Study of JNJ-90301900 in Combination With Chemoradiation Therapy in Participants With Locally Advanced Head and Neck Squamous Cell Carcinoma

for Squamous Cell Carcinoma of Head and Neck

8 locations incl. Birmingham

Sponsor: Johnson & Johnson Enterprise Innovation Inc.

Sex: All·Age: 18 - 74

Code: NCT07219212·Phase 1·Recruiting

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A Study of Buntanetap in Participants With PD

for Parkinson's Disease (PD)

27 locations incl. Birmingham

Sponsor: Annovis Bio Inc.

Sex: All·Age: 40 - 85

Code: NCT07284784·Phase 2, Phase 3·Recruiting

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A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive Disorder

for Depressive Disorder, Major

4 locations incl. Birmingham

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 12 - 17

Code: NCT07227454·Phase 3·Recruiting

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Bony Overlap Following Use of the Inferior Border Saw for the 'Low and Short' Sagittal Split: A Split-Mouth Study

for Mandibular Surgery

1 location in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 12 - 75

Code: NCT07104656·Recruiting

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A Phase 1b, Open-Label Study of DISC-3405 in Participants With Sickle Cell Disease (SCD)

for Sickle Cell Disease

7 locations incl. Birmingham

Sponsor: Disc Medicine, Inc

Sex: All·Age: 18+

Code: NCT07187973·Phase 1·Recruiting

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Supraglottic Airway for Resuscitation Trial

for Neonatal Resuscitation

30 locations incl. Birmingham

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 0 Days+

Code: NCT07150923·Recruiting

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Renal Pelvic Denervation Pilot Trial

for Uncontrolled Hypertension

5 locations incl. Birmingham

Sponsor: Verve Medical, Inc

Sex: All·Age: 21 - 80

Code: NCT07005050·Recruiting

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A Long-term Follow-up Study in Patients Who Received BEAM-101

for Hemoglobinopathy

17 locations incl. Birmingham

Sponsor: Beam Therapeutics Inc.

Sex: All·Age: 14 - 37

Code: NCT07373639·Recruiting

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A Study to Find Out How EMPAgliflozin is Tolerated and if it Helps Children and Adolescents With Chronic KIDNEY Disease (EMPA-KIDNEY® Kids)

for Chronic Kidney Disease

Drug: Empagliflozin

30 locations incl. Birmingham

Sponsor: Boehringer Ingelheim

Sex: All·Age: 2 - 17

Code: NCT07107945·Phase 3·Recruiting

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Target Trial Emulation for Pharmacologic Treatment of Neonatal Opioid Withdrawal Syndrome

for Neonatal Opioid Withdrawal Syndrome

22 locations incl. Birmingham

Sponsor: HELP for NOWS Consortium

Sex: All·Age: 0 Minutes+

Code: NCT07278375·Recruiting

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Optimizing an Extended Care Intervention to Promote Weight Loss Maintenance

for Obesity Prevention

1 location in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06785064·Recruiting

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A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease

for Parkinson's Disease

Drug: Prasinezumab

42 locations incl. Birmingham

Sponsor: Hoffmann-La Roche

Sex: All·Age: 50 - 85

Code: NCT07174310·Phase 3·Recruiting

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Inspire HER: Inspiring the Heart and Emotions for Radical Health

for Cardiovascular-kidney-metabolic Syndrome

1 location in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: Female·Age: 30 - 79

Code: NCT06966258·Recruiting

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ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response

for Major Depressive Disorder (MDD)

21 locations incl. Birmingham

Sponsor: ACADIA Pharmaceuticals Inc.

Sex: All·Age: 18 - 65

Code: NCT07284667·Phase 2·Recruiting

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