Pycnogenol (French Maritime Pine Bark) for the Treatment of Gulf War Illness

Part of paid clinical trials in Birmingham, Alabama.

Sponsor
University of Alabama at Birmingham
Study ID
NCT07266571
Status
Not Yet Recruiting

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Conditions

  • Gulf War Syndrome

Eligibility Criteria

Sex
MALE
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Placebo — OTHER
    The placebo being used in this study is microcrystalline cellulose. This will be taken orally, up to twice per day.
  • Pycnogenol, 100mg — DIETARY_SUPPLEMENT
    Pycnogenol being used in this study is a commercially available dietary supplement and is classified as food by the FDA instead of a drug. This will be taken orally, up to twice per day.
  • Pycnogenol, 200mg — DIETARY_SUPPLEMENT
    Pycnogenol being used in this study is a commercially available dietary supplement and is classified as food by the FDA instead of a drug. This will be taken orally, up to twice per day.
  • Pycnogenol, 400mg — DIETARY_SUPPLEMENT
    Pycnogenol being used in this study is a commercially available dietary supplement and is classified as food by the FDA instead of a drug. This will be taken orally, up to twice per day.
  • Pycnogenol, 600mg — DIETARY_SUPPLEMENT
    Pycnogenol being used in this study is a commercially available dietary supplement and is classified as food by the FDA instead of a drug. This will be taken orally, up to twice per day.

Study Details

The purpose of this research study is to determine how pycnogenol may reduce Gulf War Illness (GWI) symptom severity. The study will also examine the safety of this treatment and determine the optimal dosage. The investigators believe that GWI involves inflammation in the body and brain that causes fatigue, pain, cognitive disruption, and other symptoms. Botanicals that reduce inflammation may help treat GWI.

Key Dates

Start date
May 1, 2026
Status verified
Apr 2026
Primary completion
May 1, 2027
Completion
May 1, 2027

Study Design

Enrollment
20 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Participants Receiving Botanicals
    Participants Receiving Botanicals

Primary Outcome Measure

Change in Physical Functioning Score of the Veterans Rand 12-Item Health Survey [ Time Frame: 12 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Alabama at BirminghamBirminghamAlabama35243
Jarred Younger, PhD
[email protected]
205-975-5821
Jarred Younger, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
University of Alabama at Birmingham· Birmingham, AL

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