Validating Gulf War Illness Blood Biomarkers

Part of paid clinical trials in Palo Alto, California.

Sponsor
Roskamp Institute Inc.
Study ID
NCT05736146
Status
Recruiting
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Conditions

  • Gulf War Illness
  • Gulf War Syndrome

Eligibility Criteria

Sex
ALL
Age
35 Years - N/A
Healthy Volunteers
Accepted

Study Details

The investigators goals are to identify blood lipids/metabolites that correlate with cognitive decline in the presence of the APOE ε4 allele among veterans with GWI. To determine the effect of dietary, medical and biological factors that influence lipid and metabolites in blood from GW veterans. To identify blood lipid/metabolite profiles that correlate with bioenergetics deficits and glial activation in the brains of GWI. To validate blood biomarker signatures of GWI using APOE genotyping and blood lipids/metabolites that correlate with the CNS dysfunction in GWI.

Key Dates

Start date
Jun 30, 2022
Status verified
Nov 2024
Primary completion
Dec 1, 2025
Completion
Mar 1, 2026

Study Design

Enrollment
100 participants (estimated)

Arms

  • Arm: Case: GWI
    This group includes participants who served in the Gulf War during 1990 -1991 and have Gulf War Illness based on either the Kansas or CDC symptom criteria.
  • Arm: Control
    This group includes participants who served in the Gulf War during 1990 -1991 and have no symptoms of Gulf War Illness based on both the Kansas and CDC symptom criteria.

Primary Outcome Measure

Validate Blood Biomarkers [ Time Frame: 2022-2024 ]

Central Contacts

Locations (3)

FacilityCityStateZIPSite coordinators
Palto Alto Veterans Institute for ResearchPalo AltoCalifornia94304
Raj Brar
[email protected]
650-374-9073
Maheen Adamson, Ph.D (SUB_INVESTIGATOR)
The Roskamp InstituteSarasotaFlorida34232
Dakota M Helgager, B.S.
[email protected]
941-256-8019
Laila Abdullah, Ph.D (PRINCIPAL_INVESTIGATOR)
Michael Hoffmann, MD (SUB_INVESTIGATOR)
Boston UniversityBostonMassachusetts02118
Leah Orlinsky
[email protected]
617-358-2214
Kim Sullivan, Ph.D (SUB_INVESTIGATOR)

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Palto Alto Veterans Institute for Research· Palo Alto, CAThe Roskamp Institute· Sarasota, FLBoston University· Boston, MA

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