To Compare Post-Extraction Use of a Novel Ethylenediaminetetraacetic Acid (EDTA) Post-operative Mouth Rinse and Daily Use EDTA Mouth Rinse and Standard 0.12% Chlorhexidine (CHX) Post-operative Mouth Rinse and Daily Use Essential Oil (EO) Mouth Rinse.

Conditions

• Extraction Sites After Removal and Bone Replacement Grafting at Extraction Sockets of Dentally Hopeless Single-rooted Teeth

Eligibility Criteria

Sex

ALL

Age

18 Years - 85 Years

Healthy Volunteers

Accepted

Interventions

• 0.12% CHX and Essential Oil mouthrinse — OTHER
  0.12% CHX mouthrinse will be used to rinse for 1 minute with 15 mL twice daily starting day 1 after surgery through day 14. Patients will be instructed to use OTC essential oil mouthrinse 15mL once daily until the conclusion of the study (day 15 to day 84).
• 2.6% EDTA and 0.2% EDTA mouth rinse — OTHER
  .6% EDTA mouthrinse will be used to rinse for 1 minute with 15 mL twice daily starting day 1 after surgery through day 14. Patients will be instructed to use 0.2% EDTA mouthrinse 15mL once daily until the conclusion of the study (day 15 to day 84).

Study Details

This study will compare commercially available, commonly used mouth rinses (0.12% chlorhexidine (CHX) vs. Ethylenediaminetetraacetic acid (EDTA)) for immediate post-operative and daily antiseptic use after tooth extraction and ridge preservation grafting followed by daily use of commercially available an essential oil (EO) mouthrinse and EDTA mouthrinse.

Key Dates

Start date

Mar 2, 2026

Status verified

Mar 2026

Primary completion

Dec 31, 2027

Completion

Dec 31, 2028

Study Design

Enrollment

40 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Active Comparator: 0.12% CHX and Essential Oil mouthrinse
  0.12% CHX and Essential Oil mouthrinse
• Experimental: 2.6% EDTA and 0.2% EDTA mouth rinse
  2.6% EDTA and 0.2% EDTA mouth rinse

Primary Outcome Measure

The wound closure after extraction and ridge preservation grafting at 2, 4, and 8, and 12-weeks. [ Time Frame: From baseline to 2 weeks, 4 weeks, 8 weeks and 12 weeks postoperatively. ]

Central Contacts

• Maria L Geisinger, DDS, MS
  205-934-4984
  [email protected]
• Sarah Jane Startley, DMD
  205-975-8711
  [email protected]

Locations (1)

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