Clinical Trials at National Institutes of Health Clinical Center

As of June 2026, 659 paid clinical trials are recruiting at National Institutes of Health Clinical Center, located at 10 CENTER DR, BLDG. 10 ROOM 2-5940, BETHESDA, MD 20892-0001, phone (301) 496-6353 in Bethesda, Maryland. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

Filter results

Filter results

State

City

Facility

Phase

Study type

Intervention

Recruitment status

Condition

Sex

Age

Healthy volunteers only

659 clinical trials at National Institutes of Health Clinical Center

·Clear filters·↓ Download CSV

Role of Theta Frequency Oscillations in Proactive and Reactive Control Processes in Youth With Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive Compulsive Disorder (OCD)

for ADHD

1 location in Bethesda

Sponsor: National Institute of Mental Health (NIMH)

Sex: All·Age: 10 - 17

Code: NCT07566468·Not Yet Recruiting

Escalating Doses of VAS-101 in Subjects With Stable Sickle Cell Disease

for Sickle Cell Disease, Hemolytic Anemia

1 location in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 18 - 90

Code: NCT07566494·Phase 1·Not Yet Recruiting

Anti-CRLF2-R/TSLPR Chimeric Antigen Receptor T Cells (TSLPR-CART) in Participants With Recurrent or Refractory CRLF2-R/TSLPR-Overexpressing B-Cell Acute Lymphoblastic Leukemia (B-ALL)

for B-All

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT07572136·Phase 1·Not Yet Recruiting

Multitargeted Recombinant Ad5 PSA/MUC-1/Brachyury-Based Immunotherapy (TriAdeno) Vaccine With IL-15 Superagonist N-803 in Participants With Clinically Localized Prostate Cancer Undergoing Active Surveillance

for Adenocarcinoma

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: Male·Age: 18 - 120

Code: NCT07574541·Phase 2·Not Yet Recruiting

Partial Stem Cell Transplant for Sickle Cell Disease From Matched Donors

for Sickle Cell Disease

1 location in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 4 - 65

Code: NCT07599176·Phase 1, Phase 2·Recruiting

Apply to this trial

Fibrotic Disease Activity in Cardiopulmonary Disorders Using 18F-Fibroblast Activation Protein Inhibitor (18F-FAPI-74) PET/CT Imaging

for Allogeneic Stem Cell Transplantation

1 location in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 18 - 100

Code: NCT07613099·Phase 3·Not Yet Recruiting

Longitudinal Immunophenotyping of Patients With Inflammatory Bowel Disease

for Inflammatory Bowel Disease

1 location in Bethesda

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sex: All·Age: 18 - 85

Code: NCT07619547·Not Yet Recruiting

Evaluation of [11C]ZTP-1 to Image PDE4B

for Healthy

1 location in Bethesda

Sponsor: National Institute of Mental Health (NIMH)

Sex: All·Age: 18 - 101·Accepts healthy volunteers

Code: NCT07625345·Phase 1·Recruiting

Apply to this trial

Psychotherapy for Irritability in Youth: Comparing Active Treatment to Nonactive Psychoeducation Supportive Psychotherapy

for Irritability

1 location in Bethesda

Sponsor: National Institute of Mental Health (NIMH)

Sex: All·Age: 8 - 17

Code: NCT07640802·Not Yet Recruiting

Intravenous Brincidofovir as an Antiviral for Treatment of Progressive Multifocal Leukoencephalopathy: A Pilot Study

for Progressive Multifocal Leukoencephalopathy

1 location in Bethesda

Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Sex: All·Age: 18 - 99

Code: NCT07511049·Phase 2·Recruiting

Apply to this trial

Continuous Temperature Monitoring (CTM) for Cytokine Release Syndrome (CRS), an Immune-Related Adverse Event

for Cytokine Release Syndrome

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT07499128·Enrolling By Invitation

Safety and Efficacy of PTH-IA

for Jansen's Metaphyseal Chondrodysplasia

1 location in Bethesda

Sponsor: National Institute of Dental and Craniofacial Research (NIDCR)

Sex: All·Age: 3 - 100

Code: NCT07541209·Phase 1, Phase 2·Recruiting

Apply to this trial

Tirzepatide s Dopaminergic Effects in Alcohol Use Disorders (AUD)

for Alcohol Use Disorder (AUD)

Drug: Tirzepatide

1 location in Bethesda

Sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Sex: All·Age: 21 - 65

Code: NCT07559500·Phase 1·Recruiting

Apply to this trial

GRAfT 2.0. A Multimodal Prospective Approach to Define the Mechanisms and Clinical Features of Acute and Chronic Rejection in Lung Transplantation

for Lung Transplant

1 location in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 18 - 75

Code: NCT07516379·Recruiting

Apply to this trial

Rechallenge With a Low Pathogenicity Avian H10N7 Influenza Virus in Healthy Human Volunteers Previously Challenged With H10N7 Influenza

for Influenza Infection

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT07215871·Phase 1·Enrolling By Invitation

Accuracy of 18F-Fluorocholine PET/MR and NeuroEXPLORER PET/CT Imaging for Localization of Parathyroid Tumors

for Primary Hyperparathyroidism

1 location in Bethesda

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sex: All·Age: 18 - 100

Code: NCT07444723·Phase 2, Phase 3·Recruiting

Apply to this trial

THREAT: Testing Harms Related to Exposure to Allergenic and Epithelial Toxins

for Allergic

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 80

Code: NCT07271381·Recruiting

Apply to this trial

Recombinant Glycosylated Human Interleukin-7 (CYT107) for the Treatment of Kaposi Sarcoma in Participants With HIV and Immune Non-Response (REGIMENKS HIV)

for Kaposi Sarcoma

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT07308886·Phase 2·Recruiting

Apply to this trial

Tirzepatide in MetALD

for Metabolic Alcohol-associated Liver Disease

Drug: Tirzepatide

1 location in Bethesda

Sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Sex: All·Age: 21 - 100

Code: NCT07046819·Phase 2·Recruiting

Apply to this trial

Characterization of Nociception Phenotype in Individuals With Intellectual Disability

for Intellectual Disability

1 location in Bethesda

Sponsor: National Institutes of Health Clinical Center (CC)

Sex: All·Age: 8 - 30·Accepts healthy volunteers

Code: NCT05473429·Recruiting

Apply to this trial

Platelet Volunteers, Longitudinal and Multi-omic Study

for Thrombosis

1 location in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT07137429·Recruiting

Apply to this trial

Turner Syndrome: Genetic Considerations

for Genetic

1 location in Bethesda

Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Sex: All·Age: 1 Day - 110

Code: NCT07502586·Recruiting

Apply to this trial

Immune Profiling of CLL/SLL Treated With First-Line Pirtobrutinib

for Chronic Lymphocytic Leukemia (CLL)

1 location in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 18 - 100

Code: NCT07428707·EARLY_Phase 1·Recruiting

Apply to this trial

DDAVP for Pituitary Adenoma

for Cushing's Disease

1 location in Bethesda

Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Sex: All·Age: 8 - 99

Code: NCT04569591·Recruiting

Apply to this trial

Natural History Study to Determine Drug Metabolism Phenotype and Appropriate Germline Source DNA in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplant

for Leukemia

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120·Accepts healthy volunteers

Code: NCT06856226·Recruiting

Apply to this trial

A Study to Evaluate the Feasibility of a Physiologic Biomarker to Assess Pain and Other Sensory Problems Using Pupillometry in Participants With Neurofibromatosis Type 1 (NF1)

for Neurofibromatosis Type 1

2 locations incl. Washington D.C.

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 1 - 120

Code: NCT06507748·Recruiting

Apply to this trial

Baricitinib in the Treatment of Kohlmeier-Degos Disease in Patients With Neurological Involvement

for Kohlmeier-Degos Disease

Drug: Baricitinib

1 location in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 18 - 99

Code: NCT06923072·Phase 2·Recruiting

Apply to this trial

Observational Study of Responses to Treatments in Advanced Central Nervous System (CNS) Tumors

for Recurrent CNS Tumors

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 15 - 120

Code: NCT07374692·Recruiting

Apply to this trial

Enfortumab Vedotin With or Without Pembrolizumab in Rare Genitourinary Tumors (E-VIRTUE)

for Adenocarcinoma of the Bladder

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT06041503·Phase 2·Recruiting

Apply to this trial

Lenacapavir Intensification to Disrupt HIV Reservoirs in Virologically Suppressed People With HIV Receiving Antiretroviral Therapy

for Human Immunodeficiency Virus

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 75

Code: NCT06819176·Phase 1·Recruiting

Apply to this trial

Safety of Tofacitinib, an Oral Janus Kinase Inhibitor, in Primary Sjogren Disease

for Sjogren's Syndrome

Drug: Tofacitinib

1 location in Bethesda

Sponsor: National Institute of Dental and Craniofacial Research (NIDCR)

Sex: All·Age: 18 - 75

Code: NCT07281456·Phase 2·Recruiting

Apply to this trial

Acute Effects of Alcohol on PET Imaging of Phosphodiesterase-4B (PDE4B)

for Alcohol Use Disorder

1 location in Bethesda

Sponsor: National Institute of Mental Health (NIMH)

Sex: All·Age: 21 - 70

Code: NCT07027839·Phase 1·Recruiting

Apply to this trial

Phase I Trial Integrating HLA-Haploidentical Anti-CD19 CAR-T Cells With Post-Transplantation Cyclophosphamide-Based HLA-Haploidentical Hematopoietic Cell Transplantation

for Hematologic Malignancies

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 75

Code: NCT07162038·Phase 1·Recruiting

Apply to this trial

Randomized Stepped Wedge Study of Emapalumab in APECED Enteritis

for Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy Enteritis

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 2 - 75

Code: NCT07202598·Phase 2·Recruiting

Apply to this trial

A Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosing

for Locally Advanced Alveolar Soft Part Sarcoma

Drug: Atezolizumab

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT06066138·Phase 1·Recruiting

Apply to this trial

Phase I Trial of rhIL-15 Plus Dinutuximab Plus Irinotecan/Temozolomide for Children and Young Adults With Relapsed/Refractory Neuroblastoma

for Neuroblastoma

Drug: Irinotecan

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 3 - 35

Code: NCT06995872·Phase 1·Recruiting

Apply to this trial

Testing the Effectiveness of a Combination Targeted Therapy (ViPOR) for Patients With Relapsed and/or Refractory Aggressive B-cell Lymphoma

for High Grade B-Cell Lymphoma With MYC and BCL6 Rearrangements

83 locations incl. Tucson

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06649812·Phase 2·Recruiting

Apply to this trial

A Phase I Trial Anti-CC Chemokine Receptor 4 Chimeric Antigen Receptor T Cells (CCR4 CAR T Cells) for CCR4 Expressing T-cell Malignancies Including Peripheral T-cell Non-Hodgkin Lymphoma (PTCL) and Cutaneous T-cell Non-Hodgkin Lymphoma (CTCL)

for Relapsed and/or Refractory Mature T Cell Malignancy

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT07055477·Phase 1·Recruiting

Apply to this trial

Cybersickness Prevention and Mitigation in Virtual Reality for Healthy Volunteers

for Healthy Volunteers

2 locations incl. Ames

Sponsor: National Human Genome Research Institute (NHGRI)

Sex: All·Age: 18 - 60

Code: NCT06552754·Recruiting

Apply to this trial

Pembrolizumab + N-803 Alone or in Combination With PD-L1 t-haNK Cells for Resectable Head and Neck Squamous Cell Carcinoma

for Stage II Squamous Cell Carcinoma of the Head and Neck

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT06161545·Phase 2·Recruiting

Apply to this trial