Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM) When a Stem Cell Transplant is Not a Medically Suitable Treatmentfor Plasma Cell Myeloma397 locations incl. AnchorageSponsor: SWOG Cancer Research NetworkSex: All·Age: All agesCode: NCT05561387·Phase 3·RecruitingApply to this trial
Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, The ERASur Studyfor Metastatic Colorectal Adenocarcinoma184 locations incl. KingmanSponsor: Alliance for Clinical Trials in OncologySex: All·Age: 18+Code: NCT05673148·Phase 3·RecruitingApply to this trial
Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small Cell Lung Cancerfor Locally Advanced Lung Non-Small Cell Carcinoma470 locations incl. BirminghamSponsor: NRG OncologySex: All·Age: 18+Code: NCT05624996·Phase 3·RecruitingApply to this trial
Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumabfor Anatomic Stage II Breast Cancer AJCC v8820 locations incl. BirminghamSponsor: Alliance for Clinical Trials in OncologySex: All·Age: 18+Code: NCT05812807·Phase 3·RecruitingApply to this trial
Testing Drug Treatments After CAR T-cell Therapy in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphomafor Diffuse Large B-Cell Lymphoma87 locations incl. TucsonSponsor: SWOG Cancer Research NetworkSex: All·Age: 18+Code: NCT05633615·Phase 2·RecruitingApply to this trial
Comparing Cooling and/or Compression Approaches of Limbs for Prevention of Chemotherapy-Induced Peripheral Neuropathyfor Malignant Solid Neoplasm36 locations incl. BirminghamSponsor: SWOG Cancer Research NetworkSex: All·Age: 18+Code: NCT05642611·Phase 3·RecruitingApply to this trial
A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumabfor Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8Drug: Nivolumab390 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: All·Age: 5 - 60Code: NCT05675410·Phase 3·RecruitingApply to this trial
Comparing Combinations of Targeted Drugs for Advanced Non-Small Cell Lung Cancer That Has EGFR and MET Gene Changes (A Lung-MAP Treatment Trial)for Recurrent Lung Non-Small Cell Carcinoma454 locations incl. DaphneSponsor: SWOG Cancer Research NetworkSex: All·Age: 18+Code: NCT05642572·Phase 2·RecruitingApply to this trial
Testing the Use of the Combination of Selumetinib and Olaparib or Selumetinib Alone Targeted Treatment for RAS Pathway Mutant Recurrent or Persistent Ovarian and Endometrial Cancers, A ComboMATCH Treatment Trialfor Recurrent Endometrial CarcinomaDrug: Selumetinib293 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: Female·Age: 18+Code: NCT05554328·Phase 2·RecruitingApply to this trial
Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trialfor Advanced Malignant Solid Neoplasm475 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: All·Age: All agesCode: NCT05564377·Phase 2·RecruitingApply to this trial
Testing the Use of Ado-Trastuzumab Emtansine Compared to the Usual Treatment (Chemotherapy With Docetaxel Plus Trastuzumab) or Trastuzumab Deruxtecan for Recurrent, Metastatic, or Unresectable HER2-Expressing Salivary Gland Cancersfor Metastatic Salivary Gland Carcinoma150 locations incl. BirminghamSponsor: NRG OncologySex: All·Age: 18+Code: NCT05408845·Phase 2·RecruitingApply to this trial
mFOLFIRINOX Versus mFOLFOX With or Without Nivolumab for the Treatment of Advanced, Unresectable, or Metastatic HER2 Negative Esophageal, Gastroesophageal Junction, and Gastric Adenocarcinomafor Advanced Esophageal AdenocarcinomaDrug: Nivolumab785 locations incl. BirminghamSponsor: Alliance for Clinical Trials in OncologySex: All·Age: 18+Code: NCT05677490·Phase 3·RecruitingApply to this trial
BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Studyfor Clinical Stage III Cutaneous Melanoma AJCC v8Drug: Cabozantinib222 locations incl. PhoenixSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT05136196·Phase 2·RecruitingApply to this trial
Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcomafor Endometrial Carcinoma403 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: Female·Age: 18+Code: NCT05256225·Phase 3·RecruitingApply to this trial
Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detectionfor Acute Lymphoblastic Leukemia746 locations incl. AnchorageSponsor: Alliance for Clinical Trials in OncologySex: All·Age: 40 - 75·Accepts healthy volunteersCode: NCT05334069·RecruitingApply to this trial
Chemotherapy for the Treatment of Patients With Newly Diagnosed Very Low-Risk and Low Risk Fusion Negative Rhabdomyosarcomafor Embryonal Rhabdomyosarcoma165 locations incl. BirminghamSponsor: Children's Oncology GroupSex: All·Age: Up to 21Code: NCT05304585·Phase 3·RecruitingApply to this trial
Colon Adjuvant Chemotherapy Based on Evaluation of Residual Diseasefor Stage III Colon Cancer1021 locations incl. BirminghamSponsor: NRG OncologySex: All·Age: 18+Code: NCT05174169·Phase 2, Phase 3·RecruitingApply to this trial
Testing Nivolumab With or Without Ipilimumab in Deficient Mismatch Repair System (dMMR) Recurrent Endometrial Carcinomafor Endometrial AdenocarcinomaDrug: Ipilimumab137 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: Female·Age: 18+Code: NCT05112601·Phase 2·RecruitingApply to this trial
Testing the Use of Chemotherapy After Surgery for High-Risk Pancreatic Neuroendocrine Tumorsfor Metastatic Malignant Neoplasm in the Liver446 locations incl. AnchorageSponsor: SWOG Cancer Research NetworkSex: All·Age: 18+Code: NCT05040360·Phase 2·RecruitingApply to this trial
The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Studyfor Acute Lymphoblastic Leukemia164 locations incl. BirminghamSponsor: PedAL BCU, LLCSex: All·Age: Up to 22Code: NCT04726241·Phase 1, Phase 2·RecruitingApply to this trial
Reaching Rural Cancer Survivors Who Smoke Using Text-Based Programfor Cigarette Smoking-Related Carcinoma222 locations incl. KingmanSponsor: Alliance for Clinical Trials in OncologySex: All·Age: 18+Code: NCT05008848·Phase 3·RecruitingApply to this trial
Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polypsfor Adenocarcinoma of the Colon472 locations incl. FairbanksSponsor: NRG OncologySex: All·Age: 45 - 70Code: NCT05080673·RecruitingApply to this trial
Testing the Addition of MEDI4736 (Durvalumab) to Chemotherapy Before Surgery for Patients With High-Grade Upper Urinary Tract Cancerfor Renal Pelvis and Ureter Urothelial CarcinomaDrug: Durvalumab258 locations incl. KingmanSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT04628767·Phase 2, Phase 3·RecruitingApply to this trial
De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)for Stage I Breast Cancer812 locations incl. BirminghamSponsor: NRG OncologySex: All·Age: 50 - 70Code: NCT04852887·Phase 3·RecruitingApply to this trial
APOLLO: A Randomized Phase II Double-Blind Study of Olaparib Versus Placebo Following Curative Intent Therapy in Patients With Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutationfor Pancreatic Acinar Cell CarcinomaDrug: Olaparib452 locations incl. AnchorageSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT04858334·Phase 2·RecruitingApply to this trial
Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinomafor Recurrent Head and Neck Squamous Cell Carcinoma178 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: All·Age: 18 - 79Code: NCT04671667·Phase 2·RecruitingApply to this trial
Comparing the Outcome of Immunotherapy-Based Drug Combination Therapy With or Without Surgery to Remove the Kidney in Metastatic Kidney Cancer, the PROBE Trialfor Metastatic Clear Cell Renal Cell Carcinoma387 locations incl. BirminghamSponsor: SWOG Cancer Research NetworkSex: All·Age: 18+Code: NCT04510597·Phase 3·RecruitingApply to this trial
Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Studyfor Chronic Lymphocytic Leukemia621 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT04269902·Phase 3·RecruitingApply to this trial
Testing the Use of Combination Therapy in Adult Patients With Newly Diagnosed Multiple Myeloma, the EQUATE Trialfor Plasma Cell Myeloma642 locations incl. AnchorageSponsor: ECOG-ACRIN Cancer Research GroupSex: All·Age: 18+Code: NCT04566328·Phase 3·RecruitingApply to this trial
Study to Test OBI-3424 in Patients With T-Cell Acute Lymphoblastic Leukemia (T-ALL) or T-Cell Lymphoblastic Lymphoma (T-LBL)for Recurrent T Acute Lymphoblastic Leukemia163 locations incl. BirminghamSponsor: SWOG Cancer Research NetworkSex: All·Age: 12+Code: NCT04315324·Phase 1, Phase 2·RecruitingApply to this trial
Testing the Addition of Radiation Therapy to the Usual Immune Therapy Treatment (Atezolizumab) for Extensive Stage Small Cell Lung Cancer, The RAPTOR Trialfor Extensive Stage Lung Small Cell CarcinomaDrug: Atezolizumab416 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT04402788·Phase 2, Phase 3·RecruitingApply to this trial
Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung Cancerfor Advanced Lung Non-Squamous Non-Small Cell CarcinomaDrug: Bevacizumab604 locations incl. AnchorageSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT04181060·Phase 3·RecruitingApply to this trial
A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWTfor Anaplastic Kidney Wilms Tumor177 locations incl. BirminghamSponsor: Children's Oncology GroupSex: All·Age: Up to 30Code: NCT04322318·Phase 2·RecruitingApply to this trial
A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancerfor Ovarian Carcinoma539 locations incl. BirminghamSponsor: NRG OncologySex: Female·Age: 35 - 50Code: NCT04251052·RecruitingApply to this trial
A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutationsfor Acute Myeloid Leukemia185 locations incl. BirminghamSponsor: Children's Oncology GroupSex: All·Age: Up to 21Code: NCT04293562·Phase 3·RecruitingApply to this trial
Comparing the Clinical Impact of Pancreatic Cyst Surveillance Programs and Associated Biomarkersfor Pancreatic Neoplasm408 locations incl. BirminghamSponsor: ECOG-ACRIN Cancer Research GroupSex: All·Age: 50 - 75Code: NCT04239573·RecruitingApply to this trial
Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])for Lung Non-Small Cell Carcinoma1150 locations incl. AnchorageSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT04267848·Phase 3·RecruitingApply to this trial
Collection of Research Data and Samples From Patients Who Experience Immunotherapy Side Effectsfor Malignancy626 locations incl. AnchorageSponsor: Alliance for Clinical Trials in OncologySex: All·Age: All agesCode: NCT04242095·RecruitingApply to this trial
Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLyfor B Acute Lymphoblastic Leukemia203 locations incl. BirminghamSponsor: Children's Oncology GroupSex: All·Age: 365 Days - 25Code: NCT03959085·Phase 3·RecruitingApply to this trial
Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancerfor Previously Treated Non-Small Cell Lung Cancer1229 locations incl. BirminghamSponsor: SWOG Cancer Research NetworkSex: All·Age: 18+Code: NCT03851445·Phase 2, Phase 3·RecruitingApply to this trial