Nicardipine Clinical Trials (2026): 34 Studies for Hypertension & Intracerebral Hemorrhage
Hipa.ai Research · Source: ClinicalTrials.gov / AACT
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34 Nicardipine clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 27 indications (including Hypertension & Intracerebral Hemorrhage) and 6,630 total planned enrollment. 6 Phase 3 Nicardipine trials and 4 Phase 2, 10 Phase 4 are listed. 4 Nicardipine clinical trials are actively recruiting. Most recent activity: NCT06677970 (Dec 2029).
Nicardipine clinical trials at a glance: phase × recruitment status
| Phase | recruiting | completed | terminated | withdrawn | not yet recruiting | unknown | Total |
|---|---|---|---|---|---|---|---|
| Early P1 | 1 | 1 | 2 | ||||
| P1 | 2 | 1 | 3 | ||||
| P2 | 2 | 2 | 4 | ||||
| P3 | 1 | 2 | 2 | 1 | 6 | ||
| P4 | 5 | 1 | 2 | 2 | 10 | ||
| N/A | 1 | 6 | 2 | 9 |
Recruiting Nicardipine clinical trials (4)
Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).
| NCT ID | Title | Phase | Indication | Enrollment | Started |
|---|---|---|---|---|---|
| NCT06677970 | OPTIMAL-BP 2Outcome in Patients Treated With Endovascular Thrombectomy - optIMAL Blood Pressure Control 2 (OPTIMAL-BP 2) | P3 | Acute Ischemic Stroke | 176 | Oct 2024 |
| NCT07044232 | NICFASTNICardipine for Fast Achievement of Systolic BP Targets in ICH | P4 | Intracerebral Haemorrhage | 88 | Oct 2025 |
| NCT07246629 | Lumbar Drain With Intrathecal Nicardipine in Aneurysmal Subarachnoid Hemorrhage | P4 | Subarachnoid Hemorrhage | 214 | Jun 2026 |
| NCT06329635 | Treatment of Vasospasm of Aneurysmal Subarachnoid Hemorrhage With Intrathecal Nicardipine - FAST-IT Trial | N/A | Aneurysmal Subarachnoid Hemorrhage | 396 | May 2024 |
Nicardipine clinical trials by indication
Hypertension (3)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT02558023 | Uranic | P3 | terminated | The Treatment of Hypertension Associated With Severe Preeclampsia (PE). A Trial of Urapidil Versus Nicardipine |
| NCT00093925 | ECLIPSE-NIC | P3 | completed | Clevidipine in the Postoperative Treatment of Hypertension (ECLIPSE-NIC) |
| NCT00325793 | — | P4 | unknown | IV Double and Triple Concentrated Nicardipine for Stroke and ICH |
Subarachnoid Hemorrhage (2)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT07246629 | — | P4 | not yet recruiting | Lumbar Drain With Intrathecal Nicardipine in Aneurysmal Subarachnoid Hemorrhage |
| NCT00490464 | — | N/A | completed | Safety and Efficacy of Nicardipine for the Control of Blood Pressure After SAH |
Acute Ischemic Stroke (2)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT06677970 | OPTIMAL-BP 2 | P3 | recruiting | Outcome in Patients Treated With Endovascular Thrombectomy - optIMAL Blood Pressure Control 2 (OPTIMAL-BP 2) |
| NCT07277283 | AISstdy | P4 | completed | Nicardipine vs. Labetalol |
Aneurysmal Subarachnoid Hemorrhage (2)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT06329635 | — | N/A | recruiting | Treatment of Vasospasm of Aneurysmal Subarachnoid Hemorrhage With Intrathecal Nicardipine - FAST-IT Trial |
| NCT04269408 | — | P2 | completed | A Safety and Efficacy Study of NicaPlant® in Aneurysmal Subarachnoid Haemorrhage Patients Undergoing Aneurysm Clipping |
Cerebral Vasospasm (2)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT01996436 | iVAST | P4 | terminated | The Intra-arterial Vasospasm Trial |
| NCT01810302 | — | P2 | terminated | Safety Study of Nicardipine to Treat Cerebral Vasospasm |
Intracerebral Hemorrhage (2)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT01176565 | ATACH-II | P3 | terminated | Antihypertensive Treatment of Acute Cerebral Hemorrhage-II |
| NCT00415610 | ATACH | P1 | completed | Antihypertensive Treatment in Acute Cerebral Hemorrhage |
Coronary Artery Disease (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT03184155 | — | Early P1 | withdrawn | Prevention of Coronary Microvascular Dysfunction Post-PCI by Intracoronary Nicardipine |
Hemorrhagic Strokes (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT07364201 | NIC-LAB ICU | N/A | completed | A Comparison of Nicardipine and Labetalol for Blood Pressure Control in Intensive Care Patients After Hemorrhagic Stroke Brain Surgery |
Intracerebral Haemorrhage (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT07044232 | NICFAST | P4 | not yet recruiting | NICardipine for Fast Achievement of Systolic BP Targets in ICH |
Hypotensive Anesthesia (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT06093893 | — | P4 | completed | Hypotensive Anesthesia for Orthognathic Surgery |
Radial Artery Cannulation (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT05920538 | — | N/A | unknown | Effects of Subcutaneously Infiltrated Nicardipine on the Success Rate of Radial Artety Cannulation |
Vasospasm;Peripheral (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT05625503 | — | Early P1 | completed | Dilution of Verapamil During Intraarterial Administration |
Coronary Artery Bypass Grafting (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT05586347 | — | N/A | completed | Relationship Between Perioperative Carotid Blood Flow Monitoring and Cerebral Function Protection in Cardiac Surgery |
Spasm Artery (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT04538534 | — | P3 | completed | Nicardipine to Avoid Spasm in Trans Radial Percutaneous Coronary Intervention |
Ischemic Stroke (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT04205305 | OPTIMAL-BP | P4 | completed | Outcome in Patients Treated with Intraarterial Thrombectomy - OptiMAL Blood Pressure Control (OPTIMAL-BP) |
Acute Stroke (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT04116112 | BEST-II | P2 | completed | Blood Pressure After Endovascular Stroke Therapy-II |
General Surgery (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT03497351 | — | N/A | completed | Effects of Different Kinds of Hypotensive Drugs on Dynamic Hemodynamic Changing in Patients Under Surgeries |
Drug-Related Side Effects and Adverse Reactions (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT03098680 | PRIME | P1 | terminated | A Study of the Pharmacokinetic and Pharmacodynamic Responses in Healthy and Altered Human Cardiovascular Systems |
Brain Tumors (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT01951950 | — | P1 | completed | Nicardipine vs Esmolol Craniotomy Emergence |
Spinal Stenosis (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT02271191 | — | P4 | completed | Effect of Nicardipine on Renal Function in Deliberate Hypotension |
Acute Coronary Syndrome (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT01171911 | — | P4 | unknown | Comparison of Intravenous Injection of Calcium Antagonist and Beta-blockade on Endothelial Shear Stress of Coronary Artery |
Healthy Subjects (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT01175746 | — | N/A | completed | The Effect of Nicardipine on Kidney Function During Orthognathic Surgery Under Hypotensive Anesthesia |
Patients Who Are Intubated for General Anesthesia (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT01041066 | — | N/A | unknown | Nicardipine Versus Labetalol During Intubation |
Hypertensive Urgency (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT00765648 | CLUE | P4 | completed | Evaluation of Intravenous Cardene(Nicardipine)and Labetalol Use in the Emergency Department |
Aortic Aneurysm, Thoracic (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT00508118 | NICNACS | P2 | terminated | NICardipine Neuroprotection in AortiC Surgery (NICNACS) |
Hypertension During Pre-Eclampsia (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT00409253 | — | P3 | unknown | Treatment of Severe Hypertension During Pre-Eclampsia: A Preliminary Equivalence Study Between Urapidil and Nicardipine |
CVA (Cerebrovascular Accident) (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT00226096 | — | N/A | completed | Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage |
Nicardipine pivotal trial highlights (Phase 2/3/4)
Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.
| Acronym | NCT | Phase | Status | Indication | Enrollment | PubMed |
|---|---|---|---|---|---|---|
| NICFAST | NCT07044232 | P4 | not yet recruiting | Intracerebral Haemorrhage | 88 | — |
| AISstdy | NCT07277283 | P4 | completed | Acute Ischemic Stroke | 34 | PMID 23055089 |
| iVAST | NCT01996436 | P4 | terminated | Cerebral Vasospasm | 92 | PMID 12744357 |
| OPTIMAL-BP | NCT04205305 | P4 | completed | Ischemic Stroke | 306 | PMID 39819210 |
| CLUE | NCT00765648 | P4 | completed | Hypertensive Urgency | 226 | PMID 25141250 |
| OPTIMAL-BP 2 | NCT06677970 | P3 | recruiting | Acute Ischemic Stroke | 176 | — |
| Uranic | NCT02558023 | P3 | terminated | Hypertension | 14 | — |
| ATACH-II | NCT01176565 | P3 | terminated | Intracerebral Hemorrhage | 1,000 | PMID 27276234 |
| ECLIPSE-NIC | NCT00093925 | P3 | completed | Hypertension | 739 | PMID 18806012 |
| BEST-II | NCT04116112 | P2 | completed | Acute Stroke | 120 | PMID 37668620 |
| NICNACS | NCT00508118 | P2 | terminated | Aortic Aneurysm, Thoracic | 7 | PMID 11951061 |
Terminated and withdrawn Nicardipine trials (7)
Studies that ended before completion. Reasons are filed in each trial's ClinicalTrials.gov entry.
- NCT03184155withdrawnPrevention of Coronary Microvascular Dysfunction Post-PCI by Intracoronary Nicardipine
- NCT01996436terminatedThe Intra-arterial Vasospasm Trial
- NCT02558023terminatedThe Treatment of Hypertension Associated With Severe Preeclampsia (PE). A Trial of Urapidil Versus Nicardipine
- NCT03098680terminatedA Study of the Pharmacokinetic and Pharmacodynamic Responses in Healthy and Altered Human Cardiovascular Systems
- NCT01176565terminatedAntihypertensive Treatment of Acute Cerebral Hemorrhage-II
- NCT01810302terminatedSafety Study of Nicardipine to Treat Cerebral Vasospasm
- NCT00508118terminatedNICardipine Neuroprotection in AortiC Surgery (NICNACS)
All Nicardipine trials (34)
Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.
| NCT ID | Acronym | Title | Phase | Status | Enrollment | Sponsor | Started |
|---|---|---|---|---|---|---|---|
| NCT06677970 | OPTIMAL-BP 2 | Outcome in Patients Treated With Endovascular Thrombectomy - optIMAL Blood Pressure Control 2 (OPTIMAL-BP 2) | P3 | recruiting | 176 | Yonsei University | Oct 2024 |
| NCT07044232 | NICFAST | NICardipine for Fast Achievement of Systolic BP Targets in ICH | P4 | not yet recruiting | 88 | Aarhus University Hospital | Oct 2025 |
| NCT07246629 | Lumbar Drain With Intrathecal Nicardipine in Aneurysmal Subarachnoid Hemorrhage | P4 | not yet recruiting | 214 | Wake Forest University Health Sciences | Jun 2026 | |
| NCT03184155 | Prevention of Coronary Microvascular Dysfunction Post-PCI by Intracoronary Nicardipine | Early P1 | withdrawn | 0 | Thomas Jefferson University | Dec 2025 | |
| NCT06329635 | Treatment of Vasospasm of Aneurysmal Subarachnoid Hemorrhage With Intrathecal Nicardipine - FAST-IT Trial | N/A | recruiting | 396 | The Affiliated Hospital Of Guizhou Medical University | May 2024 | |
| NCT06093893 | Hypotensive Anesthesia for Orthognathic Surgery | P4 | completed | 90 | Boston Medical Center | Mar 2025 | |
| NCT07364201 | NIC-LAB ICU | A Comparison of Nicardipine and Labetalol for Blood Pressure Control in Intensive Care Patients After Hemorrhagic Stroke Brain Surgery | N/A | completed | 30 | Universitas Sumatera Utara | Nov 2025 |
| NCT07277283 | AISstdy | Nicardipine vs. Labetalol | P4 | completed | 34 | Haseki Training and Research Hospital | Feb 2025 |
| NCT01996436 | iVAST | The Intra-arterial Vasospasm Trial | P4 | terminated | 92 | Peng Roc Chen, MD | Aug 2016 |
| NCT05920538 | Effects of Subcutaneously Infiltrated Nicardipine on the Success Rate of Radial Artety Cannulation | N/A | unknown | 190 | Mahidol University | Mar 2023 | |
| NCT05625503 | Dilution of Verapamil During Intraarterial Administration | Early P1 | completed | 55 | University of Illinois at Chicago | Dec 2022 | |
| NCT04205305 | OPTIMAL-BP | Outcome in Patients Treated with Intraarterial Thrombectomy - OptiMAL Blood Pressure Control (OPTIMAL-BP) | P4 | completed | 306 | Yonsei University | Jun 2020 |
| NCT04269408 | A Safety and Efficacy Study of NicaPlant® in Aneurysmal Subarachnoid Haemorrhage Patients Undergoing Aneurysm Clipping | P2 | completed | 41 | BIT Pharma GmbH | Apr 2020 | |
| NCT04116112 | BEST-II | Blood Pressure After Endovascular Stroke Therapy-II | P2 | completed | 120 | University of Cincinnati | Jan 2020 |
| NCT05586347 | Relationship Between Perioperative Carotid Blood Flow Monitoring and Cerebral Function Protection in Cardiac Surgery | N/A | completed | 64 | Nanjing First Hospital, Nanjing Medical University | Apr 2022 | |
| NCT04538534 | Nicardipine to Avoid Spasm in Trans Radial Percutaneous Coronary Intervention | P3 | completed | 1,500 | Pr. Semir Nouira | Nov 2020 | |
| NCT02558023 | Uranic | The Treatment of Hypertension Associated With Severe Preeclampsia (PE). A Trial of Urapidil Versus Nicardipine | P3 | terminated | 14 | University Hospital, Strasbourg, France | Sep 2015 |
| NCT03098680 | PRIME | A Study of the Pharmacokinetic and Pharmacodynamic Responses in Healthy and Altered Human Cardiovascular Systems | P1 | terminated | 18 | Cambridge University Hospitals NHS Foundation Trust | Apr 2017 |
| NCT03497351 | Effects of Different Kinds of Hypotensive Drugs on Dynamic Hemodynamic Changing in Patients Under Surgeries | N/A | completed | 59 | Chinese PLA General Hospital | Apr 2018 | |
| NCT01176565 | ATACH-II | Antihypertensive Treatment of Acute Cerebral Hemorrhage-II | P3 | terminated | 1,000 | University of Minnesota | May 2011 |
| NCT01951950 | Nicardipine vs Esmolol Craniotomy Emergence | P1 | completed | 40 | Northwestern University | Sep 2013 | |
| NCT01810302 | Safety Study of Nicardipine to Treat Cerebral Vasospasm | P2 | terminated | 2 | University of Florida | Aug 2013 | |
| NCT02271191 | Effect of Nicardipine on Renal Function in Deliberate Hypotension | P4 | completed | 64 | Yonsei University | May 2012 | |
| NCT01175746 | The Effect of Nicardipine on Kidney Function During Orthognathic Surgery Under Hypotensive Anesthesia | N/A | completed | 46 | Yonsei University | Aug 2010 | |
| NCT01171911 | Comparison of Intravenous Injection of Calcium Antagonist and Beta-blockade on Endothelial Shear Stress of Coronary Artery | P4 | unknown | 200 | Nanjing Medical University | Oct 2010 | |
| NCT00409253 | Treatment of Severe Hypertension During Pre-Eclampsia: A Preliminary Equivalence Study Between Urapidil and Nicardipine | P3 | unknown | 72 | University Hospital, Strasbourg, France | Jun 2007 | |
| NCT00765648 | CLUE | Evaluation of Intravenous Cardene(Nicardipine)and Labetalol Use in the Emergency Department | P4 | completed | 226 | The Cleveland Clinic | Oct 2008 |
| NCT01041066 | Nicardipine Versus Labetalol During Intubation | N/A | unknown | 70 | Seoul National University Bundang Hospital | Sep 2009 | |
| NCT00508118 | NICNACS | NICardipine Neuroprotection in AortiC Surgery (NICNACS) | P2 | terminated | 7 | Duke University | Jan 2008 |
| NCT00415610 | ATACH | Antihypertensive Treatment in Acute Cerebral Hemorrhage | P1 | completed | 60 | University of Minnesota | Jul 2005 |
| NCT00226096 | Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage | N/A | completed | 404 | The George Institute | Nov 2005 | |
| NCT00490464 | Safety and Efficacy of Nicardipine for the Control of Blood Pressure After SAH | — | completed | 163 | University of Illinois at Chicago | Jun 2004 | |
| NCT00093925 | ECLIPSE-NIC | Clevidipine in the Postoperative Treatment of Hypertension (ECLIPSE-NIC) | P3 | completed | 739 | The Medicines Company | May 2004 |
| NCT00325793 | IV Double and Triple Concentrated Nicardipine for Stroke and ICH | P4 | unknown | 50 | OSF Healthcare System | Jan 2004 |
Nicardipine clinical trials: frequently asked questions
- How many Nicardipine clinical trials are there?
- 34 Nicardipine clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 2 are actively recruiting participants. 18 are marked completed.
- Are Nicardipine clinical trials recruiting in 2026?
- Yes — 2 Nicardipine trials are actively recruiting in 2026. See the recruiting trials and the per-state site list further down this page.
- What conditions is Nicardipine being studied for?
- Nicardipine is being studied for Hypertension, Intracerebral Hemorrhage, Acute Ischemic Stroke, Coronary Artery Disease, Cerebral Vasospasm and 37 more. The trials are grouped by indication on this page.
- What phase is Nicardipine in?
- Nicardipine clinical trials span 10 Phase 4, 6 Phase 3, 4 Phase 2, 3 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
- Who sponsors Nicardipine clinical trials?
- The lead sponsor across the most Nicardipine trials is Yonsei University, with 27 additional lead sponsors listed in the data. Each trial row links to the full study detail page including sponsor information.
Sources and methodology
Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Nicardipineas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.
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