Effect of Nicardipine on Renal Function in Deliberate Hypotension

Sponsor
Yonsei University
Study ID
NCT02271191
Phase
PHASE4
Status
Completed

Conditions

  • Spinal Stenosis

Eligibility Criteria

Sex
ALL
Age
20 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Nicardipine — DRUG
    nicardipine 1-5 ug/kg/min and remifentanil 0.05 ug/kg/min during deliberate hypotension in spine surgery

Study Details

The aim of this study was to demonstrate the effect of nicardipine on renal function with creatinine clearance, serum cystatin C, urine output and fractional excretion of sodium during deliberate hypotension for spine surgery.

Key Dates

Start date
May 31, 2012
Status verified
Oct 2014
Primary completion
Jan 31, 2013
Completion
Jan 31, 2013

Study Design

Enrollment
64 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Active Comparator: Nicardipine and Remifentanil
    intravenous nicardipine and remifentanil during deliberate hypotension
  • Placebo Comparator: Remifentanil
    intravenous remifentanil during deliberate hypotension

Primary Outcome Measure

creatinine clearance [ Time Frame: after deliberate hypotension, and POD1 ]

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