Comparison of Intravenous Injection of Calcium Antagonist and Beta-blockade on Endothelial Shear Stress of Coronary Artery

Sponsor
Nanjing Medical University
Study ID
NCT01171911
Phase
PHASE4
Status
Unknown

Conditions

  • Acute Coronary Syndrome
  • Coronary Artery Disease

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • Nicardipine , Esmolol — DRUG
    A loading dose of Nicardipine 10mg was at a bolus injected through vein , then continuous trans-venous titration at a speed 1ug/kg was kept. A loading dose of Esmolol 0.5mg/kg/min was at a bolus injected through vein , then continuous trans-venous titration at a speed 0.2mg/kg/min was kept.

Study Details

Both calcium channel antagonist and beta-blocker have cardioprotective effect. Endothelial shear stress is predictive factor of clinical outcomes in patients with obstructive stenosis. The present study aims at comparing the re-distribution of shear stress and blood velocity during whole cardiac cycle after trans-coronary injection of Nicardipine and esmolol.

Key Dates

Start date
Oct 31, 2010
Status verified
Apr 2010
Primary completion
Dec 31, 2010
Completion
Dec 31, 2010

Study Design

Enrollment
200 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Primary Outcome Measure

Endothelial shear stress assessed by computational fluid dynamics [ Time Frame: After four minutes ]

Central Contacts

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