Nicardipine Versus Labetalol During Intubation

Sponsor
Seoul National University Bundang Hospital
Study ID
NCT01041066
Status
Unknown

Conditions

  • Endotracheal Intubation
  • Patients Who Are Intubated for General Anesthesia

Eligibility Criteria

Sex
ALL
Age
20 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • labetalol — DRUG
    0.4 mg/kg labetalol intravenously 4 min before intubation
  • nicardipine — DRUG
    20 ㎍/kg nicardipine intravenously 4 min before intubation

Study Details

The aim of this study was to compare the efficacy of nicardipine and labetalol in attenuation of cardiovascular responses to endotracheal intubation.

Key Dates

Start date
Sep 30, 2009
Status verified
Sep 2009
Primary completion
Dec 31, 2009

Study Design

Enrollment
70 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Active Comparator: group L
    0.4 mg/kg labetalol
  • Active Comparator: group N
    20 ㎍/kg nicardipine

Primary Outcome Measure

hemodynamic variables (systolic blood pressure, diastolic blood pressure and mean blood pressure, heart rate) [ Time Frame: preinduction- 10 min after intubation ]

Central Contacts