Trial results for a study investigating the impact of sleep duration on blood pressure during sleep in individuals with Hypertension were posted on ClinicalTrials.gov on 2025-10-20, involving 66 participants.
Background
Hypertension, or elevated blood pressure, is a widespread health concern with significant implications for cardiovascular well-being. While various factors contribute to blood pressure regulation, the role of sleep duration and quality has gained increasing attention. This study aimed to explore the relationship between sleep duration and blood pressure levels specifically during sleep, investigating whether an intervention focused on sleep hygiene and extension could influence these nocturnal blood pressure readings. Understanding this relationship is important for developing comprehensive approaches to managing hypertension, particularly for individuals with a short sleep phenotype.
Trial design
This completed study, designated as Phase NA, enrolled 66 participants to investigate conditions including Blood Pressure, Hypertension, Elevated Blood Pressure, Sleep, and Short Sleep Phenotype. The trial's purpose was to examine the impact of sleep duration on blood pressure levels during sleep. It compared an 8-week Sleep Hygiene/Extension Intervention against a Control Condition to assess their effect on sleep blood pressure.
Key results
The trial reported mean sleep systolic and diastolic blood pressure measurements at baseline and after 8 weeks for both the control and intervention groups:
- Mean Sleep Systolic Blood Pressure (BP) at Baseline and 8 Weeks:
- For the Control Condition, mean sleep systolic BP was 100.8 mmHg (Standard Deviation 13.3) at baseline and 101.4 mmHg (Standard Deviation 13.2) at 8 weeks.
- For the Sleep Hygiene/Extension Intervention group, mean sleep systolic BP was 100.0 mmHg (Standard Deviation 9.1) at baseline and 102.3 mmHg (Standard Deviation 12.7) at 8 weeks.
- Mean Sleep Diastolic Blood Pressure (BP) at Baseline and 8 Weeks:
- For the Control Condition, mean sleep diastolic BP was 58.6 mmHg (Standard Deviation 8.2) at baseline and 60.0 mmHg (Standard Deviation 7.8) at 8 weeks.
- For the Sleep Hygiene/Extension Intervention group, mean sleep diastolic BP was 57.9 mmHg (Standard Deviation 6.5) at baseline and 60.1 mmHg (Standard Deviation 6.4) at 8 weeks.
What this means
The posted results provide specific mean values and standard deviations for sleep systolic and diastolic blood pressure at baseline and after an 8-week period for both the control and sleep hygiene/extension intervention groups. These measurements contribute to understanding the blood pressure profiles during sleep in the study participants. Without further statistical analyses or comparative data, the practical implications regarding the efficacy of the sleep hygiene/extension intervention on sleep blood pressure cannot be definitively determined from these results alone.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT05062161, titled "Sleep Duration and Blood Pressure During Sleep", were posted on 2025-10-20 on clinicaltrials.gov.