Trial results for an intervention aimed at sustainable blood pressure control in Hypertension were posted on ClinicalTrials.gov on 2026-03-12. The Enhanced Community Health Worker + Mobile Health Monitoring (eCHW+) model demonstrated a mean systolic blood pressure reduction of -10.5 mmHg and achieved blood pressure control in 61.3% of participants.
Background
Hypertension is a significant global health challenge, particularly in underserved populations. Effective strategies for blood pressure management are crucial, especially in settings like rural South Africa where access to consistent care may be limited. This trial aimed to identify optimal strategies for blood pressure management using Community Health Workers (CHWs) in conjunction with in-home blood pressure monitoring among adults, seeking to improve sustainable blood pressure control.
Trial design
This completed study, designated as Phase NA, enrolled 774 participants to investigate Hypertension. The trial was a randomized clinical trial designed to compare different strategies for blood pressure management. Participants were assigned to one of three arms: Standard of Care (SOC), a Community Health Worker Care Model (CHW), or an Enhanced Community Health Worker + Mobile Health Monitoring (eCHW+) model. The study aimed to identify the optimal strategy for sustainable blood pressure control in rural South Africa.
Key results
The trial reported significant findings across its intervention arms:
- Mean Systolic Blood Pressure (SBP) Change:
- Participants in the Standard of Care (SOC) group experienced a mean SBP change of -1.9 mmHg.
- The Community Health Worker Care Model (CHW) group showed a mean SBP change of -9.1 mmHg.
- The Enhanced Community Health Worker + Mobile Health Monitoring (eCHW+) group demonstrated the largest reduction, with a mean SBP change of -10.5 mmHg.
- Percentage of Participants With Blood Pressure Control (%):
- In the SOC group, 32.5% of participants achieved blood pressure control.
- The CHW group saw 57.4% of participants achieve blood pressure control.
- The eCHW+ group achieved blood pressure control in 61.3% of participants.
- Number of Participants Who Experienced Adverse Events (Safety):
- 4 participants in the SOC group experienced adverse events.
- 7 participants in the CHW group experienced adverse events.
- 10 participants in the eCHW+ group experienced adverse events.
Statistical analyses indicated significant differences between the groups. Linear regression analysis yielded a p-value of 0.001, while logistic regression analysis for blood pressure control resulted in a p-value of 0.025.
What this means
These results suggest that community-based interventions, particularly those enhanced with mobile health monitoring, can significantly improve blood pressure control in adults with hypertension, especially in rural settings. The substantial reductions in mean SBP and the increased rates of blood pressure control observed in the CHW and eCHW+ groups, compared to standard of care, highlight the potential for these models to address health disparities and provide sustainable management for hypertension. While adverse events were reported across all groups, the numbers were relatively low, suggesting these interventions are generally well-tolerated.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study titled "Implementation of a Combination Intervention for Sustainable Blood Pressure Control" were posted on 2026-03-12 on clinicaltrials.gov.