Trial results for a study investigating self-management and resilience in African American adults with Hypertension were posted on ClinicalTrials.gov on 2026-04-28. The study enrolled 125 participants to explore factors influencing blood pressure control and quality of life.
Background
Hypertension (HTN) rates have increased globally, with African Americans experiencing a significantly higher incidence of morbidity and mortality (43%) compared to other U.S. population groups (27%). Despite the known benefits of lifestyle modifications (such as healthy diet, reduced sodium, increased physical activity, and smoking cessation) and prescribed antihypertensive therapy, many African Americans with HTN do not adhere to their treatment regimens. Consistent and effective lifelong self-management is crucial for sustaining optimal blood pressure control and thereby reducing morbidity and mortality.
Trial design
This completed study enrolled 125 participants to examine self-management and resilience trajectories in African American adults with hypertension. The conditions investigated included Hypertension, Self-Management, Quality of Life, Compliance, Medication, and Compliance, Treatment. The trial aimed to understand associations among resilience precursors, stress response, hypertension self-management behaviors, and health outcomes.
Key results
The study collected several key measurements from the Resilience Study Cohort:
- Systolic Blood Pressure:
- Mean of 138.35 mmHg (Standard Deviation 15.18).
- Mean of 135.56 mmHg (Standard Deviation 18.93).
- Diastolic Blood Pressure:
- Mean of 79.97 mmHg (Standard Deviation 13.31).
- Mean of 76.37 mmHg (Standard Deviation 10.92).
- PROMIS Global Health-10 [Health-related Quality of Life]:
- Mean score of 12.90 (Standard Deviation 2.92).
- Mean score of 12.78 (Standard Deviation 2.93).
- Mean score of 13.61 (Standard Deviation 3.14).
- Mean score of 13.49 (Standard Deviation 2.95).
Cross-sectional correlational analyses were conducted to assess associations:
- For Systolic Blood Pressure (SBP), a Spearman's correlation coefficient of 0.25 was found with a p-value of 0.005, assessing associations among resilience precursors, stress response, and hypertension self-management behaviors.
- For Diastolic Blood Pressure (DBP), a Spearman's correlation coefficient of 0.24 was found with a p-value of 0.0065, and another correlation coefficient of 0.19 with a p-value of 0.035, assessing associations among resilience precursors, stress response, and hypertension self-management behaviors.
- For Health-related Quality of Life (HQROL), a Spearman's rank correlation coefficient of 0.31 was found with a p-value of 0.0005. Further analyses showed a correlation coefficient of 0.53 with a p-value of 0 for the Physical Subscale, and a correlation coefficient of 0.42 with a p-value of 0 for overall HQROL. These assessed associations among resilience precursors, stress response, and hypertension self-management behaviors.
What this means
The results indicate significant associations between resilience precursors, stress response, hypertension self-management behaviors, and key health outcomes in African American adults with hypertension. The correlational analyses suggest that factors related to resilience and self-management are linked to both systolic and diastolic blood pressure levels, as well as health-related quality of life. Specifically, positive correlation coefficients with low p-values (e.g., p=0.005 for SBP, p=0.0005 for HQROL, and p=0 for HQROL physical subscale) suggest that these self-management and resilience factors play a statistically significant role in the observed blood pressure and quality of life measurements within this cohort. These findings underscore the importance of addressing psychosocial factors in hypertension management, particularly within this demographic.
Source
The information for this condition update was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study "Self-Management and Resilience Trajectories in African American Adults With Hypertension" were posted on 2026-04-28 on clinicaltrials.gov.