Crownlands Observing Progression With Neurons Study

Part of paid clinical trials in Germantown, Maryland.

Sponsor
Crownlands
Study ID
NCT07611396
Status
Recruiting
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Conditions

  • Alzheimer s Disease
  • Mild Cognitive Impairment (MCI)

Eligibility Criteria

Sex
ALL
Age
55 Years - N/A
Healthy Volunteers
Accepted

Study Details

The CROWN-I Study is an observational study to learn about molecular features of Alzheimer's disease (AD) and mild cognitive impairment (MCI). The primary objective is to identify the molecular and genetic modules that differentiate patient subtypes and predict progression of AD. Participants will visit clinical sites to donate samples multiple times and perform virtual and in-person clinical assessments.

Key Dates

Start date
May 19, 2026
Status verified
Jun 2026
Primary completion
May 31, 2028
Completion
May 31, 2029

Study Design

Enrollment
160 participants (estimated)

Arms

  • Arm: Alzheimer's disease (AD)
    Participants with diagnosed Alzheimer's disease
  • Arm: Mild cognitive impairment (MCI)
    Participants with diagnosed or apparent MCI
  • Arm: Cognitively normal
    Participants who are cognitively normal

Primary Outcome Measure

Rate of change in CDR-SB [ Time Frame: From enrollment to the end of the observational period at 18 months or final visit ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Capital NeurologyGermantownMaryland20876-

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Capital Neurology· Germantown, MD

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