Genetic Studies of Early-onset Dementia

Part of paid clinical trials in New York, New York.

Sponsor
Columbia University
Study ID
NCT04906863
Status
Recruiting
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Conditions

  • Alzheimer Dementia (AD)
  • Dementia, Early Onset
  • Memory Loss
  • Mild Cognitive Impairment (MCI)

Eligibility Criteria

Sex
ALL
Age
35 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Blood draw — GENETIC
    Blood draw for identification of genetic variants associated with the development of memory problems
  • Neurocognitive testing — OTHER
    Brief memory test
  • Medical questionnaire — OTHER
    Collection of medical history

Study Details

The aim of this study is to identify genetic factors that contribute to risk and progression of early-onset dementia (loss of memory function before the age of 70 years) across all ethnic groups, including Alzheimer's Disease, mild cognitive impairment and other dementias.

Key Dates

Start date
Sep 14, 2016
Status verified
Apr 2026
Primary completion
Apr 30, 2028
Completion
Apr 30, 2028

Study Design

Enrollment
1,000 participants (estimated)

Arms

  • Arm: Mild Cognitive Impairment
    Individuals with mild cognitive impairment that began before age 70
  • Arm: Dementia/Alzheimer's Disease
    Individuals with Alzheimer's Disease or other dementia that began before age 70
  • Arm: Cognitively Healthy
    Cognitively healthy individuals over the age of 35 years with a family history of dementia.
  • Arm: Early-onset dementia prior to the age of 65.
    Individuals diagnosed with early-onset dementia prior to the age of 65.

Primary Outcome Measure

Genetic risk variants associated with early-onset dementia [ Time Frame: 2 years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Columbia University Irving Medical CenterNew YorkNew York10032
Pamela del Rosario, MD
[email protected]
212-304-7284
Christiane Reitz, MD PhD (PRINCIPAL_INVESTIGATOR)

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By research site
Columbia University Irving Medical Center· New York, NY

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