e-ALIGN: A Patient Portal-based Intervention to Align Medications With What Matters Most

Part of paid clinical trials in Baltimore, Maryland.

Sponsor
Johns Hopkins University
Study ID
NCT07454824
Status
Recruiting
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Conditions

  • Dementia
  • Mild Cognitive Impairment (MCI)
  • Potentially Inappropriate Medication Use

Eligibility Criteria

Sex
ALL
Age
65 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • e-ALIGN Patient-Portal Deprescribing — OTHER
    The intervention will consist of educational materials about deprescribing, which will be sent to the patient prior to the scheduled primary care visit.

Study Details

The overarching goal of this study is to pilot an intervention in which older adults with mild cognitive impairment and dementia and the older adult's care partners are identified in primary care and provided with educational materials through the patient portal to engage the participant in deprescribing. The multicomponent intervention, e-Align, includes delivery of educational information through the patient portal, and a pharmacist-led intervention to align medications with patient and care partner goals and reduce use of central nervous system (CNS) potentially inappropriate medicines (PIM). This work will establish the preliminary data, methods, and partnerships to undertake a multisite embedded pragmatic clinical trial. The resulting triadic-based behavioral intervention will promote patient and care partner engagement, and foster care that aligns with patients' values, and promote improved health and well-being outcomes for people with cognitive impairment and the patient's care partners through deprescribing.

Key Dates

Start date
Apr 15, 2026
Status verified
May 2026
Primary completion
Aug 1, 2026
Completion
Dec 1, 2026

Study Design

Enrollment
100 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
HEALTH_SERVICES_RESEARCH

Arms

  • Experimental: Patient Portal Deprescribing Intervention
    e-ALIGN will be piloted via the patient portal. The intervention will provide patients and care partners with an educational video on the risks of Central Nervous System-Potentially Inappropriate Medications (CNS-PIM) through the patient portal, MyChart. It will also offer the participant the opportunity to discuss deprescribing options with the patient's primary care physician (PCP) or to receive a referral to discuss deprescribing options with a clinical pharmacist who is embedded in the primary care practice. Patients who meet with the pharmacist will have two visits (intervention and follow-up). Patients who do not meet with a pharmacist will have a routine visit with the patient's PCP. Each participant will be on study (intervention period and additional follow-up) for approximately 3 months.

Primary Outcome Measure

Number of patients who open the patient portal message [ Time Frame: 1 month after sending message ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Johns Hopkins Community PhysiciansBaltimoreMaryland21209
Ariel Green, MD, MPH, PhD
[email protected]
410-550-6733

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By research site
Johns Hopkins Community Physicians· Baltimore, MD

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