Impact of Nd:YAG Laser Photobiostimulation on Healing of Gingiva

Part of paid clinical trials in Charleston, South Carolina.

Sponsor
Medical University of South Carolina
Study ID
NCT07095556
Status
Recruiting
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Conditions

  • Oral Inflammation
  • Photobiomodulation
  • Post-operative Pain Management
  • Tooth Extraction Site Healing
  • Wound Healing and Prevention

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Low-level laser therapy — OTHER
    The low-level laser applications will be made on the same day as the standard of care treatment (day 1), and then day 3, and day 7 by a study team member who is trained in the use of the laser device. The laser photobiostimulation will be applied using LightWalker® laser (FOTONA), with following settings, Nd:YAG laser 1064 nm, MSP modality (pulse duration), 0.5 W (power), 10 Hz (frequency), 1 min/ 1 cm2 spot using Genova handpiece from buccal, lingual, and occlusal aspects. The Genova handpiece will be placed 1 cm away from gingival tissue. Participants and operators will wear glasses to protect their eyes from laser beam in all sessions.

Study Details

The intervention in this study is to determine whether multiple applications of photobiostimulation with Nd-YAG laser improve wound healing following tooth extraction and alveolar ridge preservation. Investigators plan to assess the impact of laser treatment on wound healing by measuring salivary biomarkers, gingival wound size and surveying for the use of pain reduction and patient satisfaction. The intervention group will receive extraction and alveolar ridge preservation with Nd-YAG laser photobiostimulation on days 1, 3, and 7 following extraction and socket preservation, while the control group will receive the standard of care extraction and alveolar ridge preservation without the laser

Key Dates

Start date
Nov 5, 2025
Status verified
Nov 2025
Primary completion
Dec 31, 2026
Completion
Apr 30, 2027

Study Design

Enrollment
39 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • No Intervention: Control
    Sham laser will be applied instead of the low-level laser.
  • Experimental: Intervention
    Low-level lase therapy will be applied at tooth extraction sites.

Primary Outcome Measure

Inflammatory markers in saliva [ Time Frame: From day of tooth extraction through day 7 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
MUSC College of Dental Medicine, Graduate Periodontics ClinicCharlestonSouth Carolina29425
Joe Gambacorta, DDS
[email protected]
843-876-7645
Ben (Hua-Hong) Chien, DDS
[email protected]

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By research site
MUSC College of Dental Medicine, Graduate Periodontics Clinic· Charleston, SC

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