Wound Healing Following Extraction and Ridge Preservation in Smokers and Non-smokers

Part of paid clinical trials in Milwaukee, Wisconsin.

Sponsor
Marquette University
Study ID
NCT07372183
Status
Not Yet Recruiting

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Conditions

  • Alveolar Bone Grafting
  • Bone Healing
  • Smoking, Cigarette
  • Tooth Extraction Site Healing
  • Wound Healing

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Accepted

Interventions

  • observational study — OTHER
    Observational study; alveolar ridge preservation

Study Details

The goal of this study is to evaluate bone wound healing following extraction and alveolar ridge preservation (bone graft and membrane) clinically, histologically and in relation to gene expression in smokers and non-smokers. Data from a small group of participants will be analyzed after age-matched subjects undergo extraction and alveolar ridge preservation prior to implant placement. The data obtained in this pilot study will be used to plan a full-fledged study involving a larger number of smoking and non-smoking participants to compare the two groups.

Key Dates

Start date
Jan 25, 2026
Status verified
Jan 2026
Primary completion
Oct 1, 2028
Completion
Oct 1, 2028

Study Design

Enrollment
12 participants (estimated)

Arms

  • Arm: Smokers
    Subjects are qualified as smokers if they report smoking ≥10 cigarettes/day for ≥5 years, and maintain a 8ppm carbon monoxide concentration or higher via smokerlyzer test.
  • Arm: Non-smokers
    Subjects qualify as nonsmokers if they have never smoked and upon confirmation by the smokerlyzer test of carbon monoxide concentation of less than 8ppm.

Primary Outcome Measure

Clinical Parameters [ Time Frame: Measured before surgery, during surgery and at 4 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Marquette University School of Dentistry Graduate Periodontics ClinicMilwaukeeWisconsin53233
Vrisiis Kofina, DDS, MS
[email protected]
4142886521
Arndt Guentsch, DMD, PhD, MHBA, MS
[email protected]
4142886089
Vrisiis Kofina, DDS, MS (PRINCIPAL_INVESTIGATOR)

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By research site
Marquette University School of Dentistry Graduate Periodontics Clinic· Milwaukee, WI

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